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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Family Characteristics

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Disease relevance of Family Characteristics


Psychiatry related information on Family Characteristics


High impact information on Family Characteristics

  • The switch, observed in mice, from the fetal use of JH-proximal VH gene segments to an adult VH use dependent upon VH family size may therefore not occur in humans [11].
  • Among children born in Scandinavia, the odds ratios (adjusted for gender, socioeconomic status, and family size) for being seropositive were 39.1 (95% confidence interval, 16.7-91.3) and 5.6 (1.8-17.3) when having parents born in high and medium prevalence areas, respectively, relative to children with Scandinavian parents [12].
  • CTRP-1 is a novel member of the C1qTNF-related protein family containing family characteristic collagen and TNF-like domains and shows marked expression in vascular wall tissue [13].
  • Childbearing decisions and family size among women with rheumatoid arthritis [14].
  • No consistent risk factor for inverse seroconversions was present, although seroconversions were most frequent in siblings with older age, male sex, HLA phenotypes other than DR3/DR4, a small family size, and no other autoantibodies detectable at seroconversion [15].

Anatomical context of Family Characteristics

  • In recent years, the increased demand for sterilization by women who have achieved their desired family size has emphasized the need to improve both existing methods of tubal occlusion and the means of access to the Fallopian tubes [16].

Associations of Family Characteristics with chemical compounds

  • Family size increased when several proteins were subsequently added based on amino acid homology, including PL-related proteins 1 and 2, phosphatidylserine phospholipase A1, and endothelial lipase [17].
  • The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size [18].
  • We used regression models to predict the log of the cotinine level of the participants with the following independent covariates: age; race/ethnicity; number of rooms in the home; sex; parental education; family poverty index; family size; region; and, among children with reported passive smoke exposure, the number of cigarettes smoked in the home [19].
  • People of white ethnic background had roughly two times higher mite allergen concentrations, while family income, family size, and education level only marginally influenced mite allergen concentrations [20].
  • Prominent determinants of zinc status were intakes of beta-carotene and zinc along with environmental conditions and family size [21].

Gene context of Family Characteristics

  • A high prevalence of BRCA1/2 mutations was found among women in the high-risk category with particular family features (i.e., small family size, predominantly male pedigree, specific cancers; 23.5%) and among women with isolated BC before age 41 and with five or fewer close adult female relatives (16.6%) [22].
  • Individual and family characteristics associated with protein truncating BRCA1 and BRCA2 mutations in an Ontario population based series from the Cooperative Family Registry for Breast Cancer Studies [23].
  • We sought to test this hypothesis in a population-based sample of twin families, while controlling for the effects of other proband and family characteristics in a multivariant logistic regression framework using both latent class and DSM-IV ADHD subtype definitions [24].
  • RESULTS: Atopy was negatively associated with family size (OR = 0. 93; 95% CI = 0.90-0.96 per 1 sib), partly attributable to an independent protective effect of a greater number of brothers (OR = 0.92; 95% CI = 0.89-0.95 per 1 brother) [25].
  • Fertility in HD is not reduced, but it appears that at risk patients have actively limited their family size [26].

Analytical, diagnostic and therapeutic context of Family Characteristics


  1. Farm environment in childhood prevents the development of allergies. Kilpeläinen, M., Terho, E.O., Helenius, H., Koskenvuo, M. Clin. Exp. Allergy (2000) [Pubmed]
  2. Familial clustering of end-stage renal disease in blacks with lupus nephritis. Freedman, B.I., Wilson, C.H., Spray, B.J., Tuttle, A.B., Olorenshaw, I.M., Kammer, G.M. Am. J. Kidney Dis. (1997) [Pubmed]
  3. Male fertility in Crohn's disease. Burnell, D., Mayberry, J., Calcraft, B.J., Morris, J.S., Rhodes, J. Postgraduate medical journal. (1986) [Pubmed]
  4. New insights into sexual functioning and fertility in rheumatic diseases. Østensen, M. Best practice & research. Clinical rheumatology. (2004) [Pubmed]
  5. Parent relationships and compliance in cystic fibrosis. Eddy, M.E., Carter, B.D., Kronenberger, W.G., Conradsen, S., Eid, N.S., Bourland, S.L., Adams, G. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners. (1998) [Pubmed]
  6. Differential effect of environmental adversity by gender: Rutter's index of adversity in a group of boys and girls with and without ADHD. Biederman, J., Faraone, S.V., Monuteaux, M.C. The American journal of psychiatry. (2002) [Pubmed]
  7. Epilepsy, pseudoseizures and perceived family characteristics: a controlled study. Moore, P.M., Baker, G.A., McDade, G., Chadwick, D., Brown, S. Epilepsy Res. (1994) [Pubmed]
  8. Familial clusters of nasopharyngeal carcinoma and salivary gland carcinomas in Greenland natives. Albeck, H., Bentzen, J., Ockelmann, H.H., Nielsen, N.H., Bretlau, P., Hansen, H.S. Cancer (1993) [Pubmed]
  9. Evaluating therapist competency and adherence to behavioral family management with bipolar patients. Weisman, A.G., Okazaki, S., Gregory, J., Goldstien, M.J., Tompson, M.C., Rea, M., Miklowitz, D.J. Family process. (1998) [Pubmed]
  10. Families of children with attention-deficit/hyperactivity disorder: review and recommendations for future research. Johnston, C., Mash, E.J. Clinical child and family psychology review. (2001) [Pubmed]
  11. A deletion map of the human immunoglobulin heavy chain variable region. Walter, M.A., Dosch, H.M., Cox, D.W. J. Exp. Med. (1991) [Pubmed]
  12. Helicobacter pylori infection in Swedish school children: lack of evidence of child-to-child transmission outside the family. Tindberg, Y., Bengtsson, C., Granath, F., Blennow, M., Nyrén, O., Granström, M. Gastroenterology (2001) [Pubmed]
  13. C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Lasser, G., Guchhait, P., Ellsworth, J.L., Sheppard, P., Lewis, K., Bishop, P., Cruz, M.A., Lopez, J.A., Fruebis, J. Blood (2006) [Pubmed]
  14. Childbearing decisions and family size among women with rheumatoid arthritis. Katz, P.P. Arthritis Rheum. (2006) [Pubmed]
  15. Dynamic pattern of disease-associated autoantibodies in siblings of children with type 1 diabetes: a population-based study. Savola, K., Läärä, E., Vähäsalo, P., Kulmala, P., Akerblom, H.K., Knip, M. Diabetes (2001) [Pubmed]
  16. A comparison of laparoscopy and culdoscopy for internal sterilization. Koetsawang, S., Bhiraleus, P., Wallman, J.A., Pachauri, S. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1976) [Pubmed]
  17. The lipase gene family. Wong, H., Schotz, M.C. J. Lipid Res. (2002) [Pubmed]
  18. The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size. Khan, W.N., Teglund, S., Bremer, K., Hammarström, S. Genomics (1992) [Pubmed]
  19. Predictors of cotinine levels in US children: data from the Third National Health and Nutrition Examination Survey. Mannino, D.M., Caraballo, R., Benowitz, N., Repace, J. Chest (2001) [Pubmed]
  20. The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States. van Strien, R.T., Gehring, U., Belanger, K., Triche, E., Gent, J., Bracken, M.B., Leaderer, B.P. Allergy (2004) [Pubmed]
  21. Factors influencing zinc status of apparently healthy indians. Agte, V.V., Chiplonkar, S.A., Tarwadi, K.V. Journal of the American College of Nutrition. (2005) [Pubmed]
  22. Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France. Bonadona, V., Sinilnikova, O.M., Chopin, S., Antoniou, A.C., Mignotte, H., Mathevet, P., Brémond, A., Martin, A., Bobin, J.Y., Romestaing, P., Raudrant, D., Rudigoz, R.C., Léoné, M., Chauvin, F., Easton, D.F., Lenoir, G.M., Lasset, C. Genes Chromosomes Cancer (2005) [Pubmed]
  23. Individual and family characteristics associated with protein truncating BRCA1 and BRCA2 mutations in an Ontario population based series from the Cooperative Family Registry for Breast Cancer Studies. Ozcelik, H., Knight, J.A., Glendon, G., Yazici, H., Carson, N., Ainsworth, P.J., Taylor, S.A., Feilotter, H., Carter, R.F., Boyd, N.F., Andrulis, I.L. J. Med. Genet. (2003) [Pubmed]
  24. Family factors and sampling approach differentially influence attention deficit/hyperactivity disorder subtypes. Todd, R.D., Joyner, C.A., Ji, T.H., Sun, L., Reich, W., Neuman, R.J. Mol. Psychiatry (2004) [Pubmed]
  25. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. Svanes, C., Jarvis, D., Chinn, S., Burney, P. J. Allergy Clin. Immunol. (1999) [Pubmed]
  26. The epidemiology of Huntington's disease in Northern Ireland. Morrison, P.J., Johnston, W.P., Nevin, N.C. J. Med. Genet. (1995) [Pubmed]
  27. Pregnancy outcome and family size in systemic lupus erythematosus: a case-control study. Hardy, C.J., Palmer, B.P., Morton, S.J., Muir, K.R., Powell, R.J. Rheumatology (Oxford, England) (1999) [Pubmed]
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