Disease relevance of Water Intoxication

• Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke [1].
• Patients with renal insufficiency who are receiving hypotonic fluids following moderate-dose IV cyclophosphamide administration may be at greatest risk for development of symptomatic water intoxication [2].
• In the psychiatric population, psychogenic polydipsia leading to water intoxication and nephrogenic diabetes insipidus secondary to lithium therapy are both well-recognized entities [3].
• We conclude 1) PDE3 or PDE4 inhibition exacerbates LPS-induced renal failure in conscious rats; and 2) LPS treated rats develop an escape from AVP in the CDs, which could be aimed to protect against water intoxication in septic conditions associated with decreased GFR and high levels of AVP [4].
• CONCLUSION: Nausea after transcervical resection of the endometrium with 1.5% glycine for irrigation may be partly explained by toxic effects of glycine and its secondary metabolites in addition to the effects of water intoxication and hyponatremia [5].

Psychiatry related information on Water Intoxication

• We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis [6].
• The symptoms of water intoxication included polyuria, nausea, tremors, weight gain, disorientation, coma and fits [7].

High impact information on Water Intoxication

• Water intoxication after nebulised tribavirin [8].
• Psychosis, inappropriate antidiuretic hormone secretion, and water intoxication [9].
• Letter: Water intoxication and thioridazine [10].
• Water intoxication precipitated by thiazide diuretics in polydipsic psychiatric patients [11].
• Water intoxication following moderate-dose intravenous cyclophosphamide [2].

Chemical compound and disease context of Water Intoxication

• Continued administration of vasopressin has relieved the symptoms and has not resulted in water intoxication [12].
• Demeclocycline in the prophylaxis of self-induced water intoxication [13].
• Water intoxication and lithium [14].
• Comparison of enalapril and captopril in the management of self-induced water intoxication [15].
• Demeclocycline (7-chloro-6 demethyl tetracycline) (DMC) corrected the CBZ-induced water intoxication in a 51-year-old man with refractory complex partial seizures and a normal antidiuretic hormone (ADH) level [16].

Biological context of Water Intoxication

• The effects of acute and chronic water intoxication induced by the administration of oral water and arginine vasopressin (AVP) or 1-deamino-8-D-arginine-vasopressin (DDAVP) on blood acid-base equilibrium and aldosterone, corticosterone, and thyroxine secretion were studied in rats [17].
• Administering i.v. cyclophosphamide requires careful monitoring of fluid balance in order to avoid water intoxication [18].

Gene context of Water Intoxication

• A selective removal of perivascular AQP4 by alpha-syntrophin deletion delays the buildup of brain edema (assessed by Diffusion-weighted MRI) following water intoxication, despite the presence of a normal complement of endothelial AQP4 [19].
• We hypothesize that the primary low sensitivity of AVP secretion response to osmo-receptor and the secondary renal hypersensitivity of AVP receptor may play the major role in the occurrence of water intoxication, linked to SIADH, in schizophrenic patients [20].
• Features of gross water intoxication (e.g., confusion, coma) have not occurred [21].
• ASC and water intoxication [22].
• Water intoxication: a complication of nebulization with nasal CPAP [23].

Analytical, diagnostic and therapeutic context of Water Intoxication

• Aquaporin levels are up-regulated in animal models of trauma, stroke and water intoxication as well as around human malignant brain tumors [24].

References