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Chemical Compound Review

Declomycin     (2Z,4S,4aS,5aR,6S,12aS)-2- (amino-hydroxy...

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Disease relevance of Declomycin


High impact information on Declomycin


Chemical compound and disease context of Declomycin

  • Current treatment options for hyponatremia in CHF include hypertonic saline solution, loop diuretics, fluid restriction, and other pharmacologic agents, such as demeclocycline, lithium carbonate, and urea [9].
  • When antibiotics were given after the development of clinical signs, antibiotics ranked in the order of reducing clinical signs and in preventing body weight loss and an intestinal enlargement were doxycycline, demeclocycline and rifampin [10].
  • His SIADH was managed successfully with saline infusion, frusemide, and maintenance treatment with demeclocycline [11].
  • For the few chronically ill people in these trials, neither the 'active' tetracycline bacteriostatic agent, oral demeclocycline, nor the opiate antagonist naloxone, nor placebo, gave any suggestion of serious adverse effects for a period of up to six weeks [12].
  • These studies demonstrate that the concentrating defect induced by demeclocycline can occur independent of alterations in praostaglandin biosynthesis and suggest that a change in renal prostaglandin biosynthesis is not an etiologic factor in demeclocycline-induced polyuria [13].

Biological context of Declomycin


Anatomical context of Declomycin


Associations of Declomycin with other chemical compounds

  • In addition, restriction of water or administration of demeclocycline improved plasma sodium and plasma vasopressin levels relative to plasma osmolality to be normal [21].
  • In all patients inappropriately concentrated urine (mean urine osmolality = 548 mOSM/kg H2O) or increased urine content of sodium (mean urine sodium = 91 mEq/L) were documented prior to demeclocycline therapy [22].
  • The use of lithium is not recommended due to the incidence of digestive, cardiac, thyroid, and central nervous system side effects, as well as the demonstrated superiority of demeclocycline [23].
  • Ledermix Paste is a paste containing triamcinolone and demeclocycline with demonstrated anti-inflammatory activity that may slow down resorptive processes after severe traumatic injuries to the dentition [24].
  • In all patients the clinical state and laboratory findings fulfilled the criteria for SIAD, which was supported by either nonsuppressible plasma AVP levels or effectiveness of treatments with water restriction, demeclocycline, nonpeptide V2 AVP antagonist or diphenylhydantoin [25].

Gene context of Declomycin

  • When hyponatremia was corrected by water restriction or demeclocycline administration, plasma ANP levels decreased significantly and fell into the normal range (12.5 +/- 4.3 pmol/L) [26].
  • The findings are consistent with direct antagonism by demeclocycline of the enhancing effect of carbamazepine on endogenous ADH activity [27].
  • Eight patients (7 men and 1 woman, mean age 43.1 +/- 8.9 years) with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) underwent treatment with demeclocycline in an effort to normalize serum sodium levels and thereby protect the PIP patients against complications including hyponatremic seizures and coma [28].

Analytical, diagnostic and therapeutic context of Declomycin


  1. Plasma demeclocycline levels and nephrotoxicity. Correlation in hyponatremic cirrhotic patients. Miller, P.D., Linas, S.L., Schrier, R.W. JAMA (1980) [Pubmed]
  2. Demeclocycline and renal insufficiency. Kirkpatrick, R. JAMA (1978) [Pubmed]
  3. Demeclocycline-induced renal failure. Oster, J.R., Epstein, M. Lancet (1977) [Pubmed]
  4. The binding of 6-demethylchlortetracycline to 70S, 50S and 30S ribosomal particles: a quantitative study by fluorescence anisotropy. Epe, B., Woolley, P. EMBO J. (1984) [Pubmed]
  5. Letter: Demeclocycline treatment of water retention in cirrhosis. Troyer, A., Pilloy, W., Broeckaert, I., Demanet, J.C. Ann. Intern. Med. (1976) [Pubmed]
  6. Chemotherapy rather than demeclocycline for inappropriate secretion of antidiuretic hormone. Cohen, M.H., Bunn, P.A., Ihde, D.C., Fossieck, B.E., Minna, J.D. N. Engl. J. Med. (1978) [Pubmed]
  7. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. Forrest, J.N., Cox, M., Hong, C., Morrison, G., Bia, M., Singer, I. N. Engl. J. Med. (1978) [Pubmed]
  8. Renal failure associated with demeclocycline in cirrhosis. Carrilho, F., Bosch, J., Arroyo, V., Mas, A., Viver, J., Rodes, J. Ann. Intern. Med. (1977) [Pubmed]
  9. Current treatments and novel pharmacologic treatments for hyponatremia in congestive heart failure. Goldsmith, S.R. Am. J. Cardiol. (2005) [Pubmed]
  10. Effect of antibiotics on clinical, pathologic and immunologic responses in murine Potomac horse fever: protective effects of doxycycline. Rikihisa, Y., Jiang, B.M. Vet. Microbiol. (1989) [Pubmed]
  11. The syndrome of inappropriate antidiuretic hormone secretion with carcinoma of the tongue. Abdi, E.A., Bishop, S. Med. Pediatr. Oncol. (1988) [Pubmed]
  12. Pharmacological treatments for psychosis-related polydipsia. Brookes, G., Ahmed, A.G. Cochrane database of systematic reviews (Online) (2006) [Pubmed]
  13. Effect of prostaglandin inhibition on demeclocycline administration in conscious rats. Serros, E.R., Lowe, A.G., Kirschenbaum, M.A. Prostaglandins and medicine. (1980) [Pubmed]
  14. Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture. Leung, D.W., Lindlief, L.A., Laabich, A., Vissvesvaran, G.P., Kamat, M., Lieu, K.L., Fawzi, A., Kubota, R. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  15. The ocular hypotensive effects of demeclocycline, tetracycline and other tetracycline derivatives. Wallace, I., Krupin, T., Stone, R.A., Moolchandani, J. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  16. Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies. Braden, G.L., Geheb, M.A., Shook, A., Singer, I., Cox, M. Am. J. Kidney Dis. (1985) [Pubmed]
  17. Occult pulmonary malignancy in syndrome of inappropriate ADH secretion with normal ADH levels. Cohen, I.M., Warren, S.E., Skowsky, W.R. Chest (1984) [Pubmed]
  18. Disposition kinetics and distribution of demeclocycline in various biological fluids in female goats. Jha, V.K., Jayachandran, C., Singh, M.K. Vet. Res. Commun. (1989) [Pubmed]
  19. In vitro susceptibilities of Ehrlichia risticii to eight antibiotics. Rikihisa, Y., Jiang, B.M. Antimicrob. Agents Chemother. (1988) [Pubmed]
  20. Quantitative assessment of dentin bridge formation following pulp-capping in miniature swine. Oguntebi, B.R., Heaven, T., Clark, A.E., Pink, F.E. Journal of endodontics. (1995) [Pubmed]
  21. Syndrome of inappropriate antidiuresis without involving inappropriate secretion of vasopressin in an elderly woman: effect of intravenous administration of the nonpeptide vasopressin V2 receptor antagonist OPC-31260. Kamoi, K. Nephron (1997) [Pubmed]
  22. Serious hyponatremia in patients with cancer: management with demeclocycline. Trump, D.L. Cancer (1981) [Pubmed]
  23. The pharmacologic management of the syndrome of inappropriate secretion of antidiuretic hormone. Miyagawa, C.I. Drug intelligence & clinical pharmacy. (1986) [Pubmed]
  24. Effect of immediate intracanal placement of Ledermix Paste(R) on healing of replanted dog teeth after extended dry times. Bryson, E.C., Levin, L., Banchs, F., Abbott, P.V., Trope, M. Dental traumatology : official publication of International Association for Dental Traumatology. (2002) [Pubmed]
  25. Osmoregulation of vasopressin secretion in patients with the syndrome of inappropriate antidiuresis associated with central nervous system disorders. Kamoi, K., Toyama, M., Takagi, M., Koizumi, T., Niishiyama, K., Takahashi, K., Sasaki, H., Muto, T. Endocr. J. (1999) [Pubmed]
  26. Atrial natriuretic peptide in patients with the syndrome of inappropriate antidiuretic hormone secretion and with diabetes insipidus. Kamoi, K., Ebe, T., Kobayashi, O., Ishida, M., Sato, F., Arai, O., Tamura, T., Takagi, A., Yamada, A., Ishibashi, M. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  27. Partial reversal of carbamazepine-induced water intolerance by demeclocycline. Ballardie, F.W., Mucklow, J.C. British journal of clinical pharmacology. (1984) [Pubmed]
  28. The use of demeclocycline in the treatment of patients with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome). Vieweg, W.V., Wilkinson, E.C., David, J.J., Rowe, W.T., Hobbs, W.B., Spradlin, W.W. The Psychiatric quarterly. (1988) [Pubmed]
  29. Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion. Cherrill, D.A., Stote, R.M., Birge, J.R., Singer, I. Ann. Intern. Med. (1975) [Pubmed]
  30. High-throughput analysis of tetracycline and penicillin antibiotics in animal tissues using electrospray tandem mass spectrometry with selected reaction monitoring transition. Goto, T., Ito, Y., Yamada, S., Matsumoto, H., Oka, H. Journal of chromatography. A. (2005) [Pubmed]
  31. Quantitative analysis of demeclocycline by high-performance liquid chromatography. Weng, N.D., Roets, E., Hoogmartens, J. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
  32. Preparation and Characterization of Demeclocycline Liposomal Formulations and Assessment of their Intraocular Pressure-Lowering Effects. Afouna, M.I., Khattab, I.S., Reddy, I.K. Cutaneous and ocular toxicology. (2005) [Pubmed]
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