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Chemical Compound Review

beclomethasone     9-chloro-11,17-dihydroxy-17- (2...

Synonyms: AGN-PC-008HNS, SureCN13423587, AC1L1DDX
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Disease relevance of beclomethasone


Psychiatry related information on beclomethasone


High impact information on beclomethasone

  • METHODS: We conducted a randomized, multicenter trial of inhaled beclomethasone or placebo in 253 infants, 3 to 14 days old, born before 33 weeks of gestation and weighing 1250 g or less at birth, who required ventilation therapy [1].
  • In a multicenter trial we compared three inhalation regimens in which a beta 2-agonist (terbutaline, 2000 micrograms daily) was combined with a corticosteroid (beclomethasone, 800 micrograms daily), an anticholinergic bronchodilator (ipratropium bromide, 160 micrograms daily), or placebo [7].
  • Combined therapy with salbutamol and beclomethasone inhalers in chronic asthma [8].
  • CONCLUSIONS: Adding beclomethasone, 800 micrograms daily, slowed the unfavorable course of asthma or COPD seen with bronchodilator therapy alone [9].
  • Beclomethasone treatment was associated with improvement in peak expiratory flow rate, alleviation of symptoms, and a decrease in the number of exacerbations in both patient groups [9].

Chemical compound and disease context of beclomethasone


Biological context of beclomethasone

  • Patients: Volunteer sample of 24 patients attending an asthma clinic who had developed cough, with or without wheezing, after inhaling beclomethasone aerosol [14].
  • Tissue culture experiments suggested that beclomethasone, a glucocorticoid used to treat the patient, was able to up-regulate PSA gene expression [15].
  • CONCLUSIONS: Asthmatic patients receiving high dose inhaled beclomethasone and intermittent courses of systemic corticosteroids have reduced vertebral bone density [16].
  • In the adult open-label study, however, the effect of beclomethasone on mean forced expiratory volume in 1 second (FEV1) gradually decreased from start of the study to the end of the follow-up treatment period [17].
  • Beclomethasone inhibited the LAR compared with placebo (P = 0.02) when expressed as AUC (6-9 h) [18].

Anatomical context of beclomethasone


Associations of beclomethasone with other chemical compounds


Gene context of beclomethasone


Analytical, diagnostic and therapeutic context of beclomethasone

  • Ileostomy effluent was collected for a minimum of 8 h and analyzed by high-performance liquid chromatography for BDP, its pharmacologically active derivative beclomethasone monopropionate (BMP), and inactive beclomethasone alcohol [32].
  • In a cross-sectional study, slit-lamp examinations were done on 95 consecutive young patients who were taking inhaled beclomethasone or budesonide [33].
  • METHODS: We performed a randomized, double-blind, crossover study in nine patients with chronic asthma requiring a high dose (2 mg/day) of inhaled beclomethasone for clinical control [34].
  • METHODS: We examined the effects of doses of 800 micrograms/day or greater of beclomethasone or budesonide for more than 18 months in 37 asthmatic subjects (group A), matched to a control group of 37 asthmatic subjects using little or no inhaled steroids (< 500 micrograms, group B) [35].
  • In this randomized, crossover, double-blind study, subjects (paired for baseline PC20 and duration of symptoms after exposure) received either placebo or 1,000 micrograms of inhaled beclomethasone daily for 1 yr, followed by the alternate medication for 6 mo [36].


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  4. Comparison of beclomethasone dipropionate aqueous nasal spray, astemizole, and the combination in the prophylactic treatment of ragweed pollen-induced rhinoconjunctivitis. Juniper, E.F., Kline, P.A., Hargreave, F.E., Dolovich, J. J. Allergy Clin. Immunol. (1989) [Pubmed]
  5. Increased beclomethasone-induced vasoconstriction in women with posttraumatic stress disorder. Coupland, N.J., Hegadoren, K.M., Myrholm, J. Journal of psychiatric research. (2003) [Pubmed]
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  8. Combined therapy with salbutamol and beclomethasone inhalers in chronic asthma. Clark, R.A., Anderson, P.B. Lancet (1978) [Pubmed]
  9. Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids. A 4-year prospective study. Dompeling, E., van Schayck, C.P., van Grunsven, P.M., van Herwaarden, C.L., Akkermans, R., Molema, J., Folgering, H., van Weel, C. Ann. Intern. Med. (1993) [Pubmed]
  10. Minimum dose requirements of steroid-dependent asthmatic patients for aerosol beclomethasone and oral prednisone. Toogood, J.H., Lefcoe, N.M., Haines, D.S., Chuang, L., Jennings, B., Errington, N., Baksh, L., Cauchi, M. J. Allergy Clin. Immunol. (1978) [Pubmed]
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  12. Influence of treatment with beclomethasone, cromoglycate and theophylline on perception of bronchoconstriction in patients with bronchial asthma. Higgs, C.M., Laszlo, G. Clin. Sci. (1996) [Pubmed]
  13. Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis. Dockhorn, R., Aaronson, D., Bronsky, E., Chervinsky, P., Cohen, R., Ehtessabian, R., Finn, A., Grossman, J., Howland, W., Kaiser, H., Pearlman, D., Sublett, J., Ratner, P., Settipane, G., Sim, T., Storms, W., Webb, R., Drda, K., Wood, C. Ann. Allergy Asthma Immunol. (1999) [Pubmed]
  14. Cough and wheezing from beclomethasone dipropionate aerosol are absent after triamcinolone acetonide. Shim, C.S., Williams, M.H. Ann. Intern. Med. (1987) [Pubmed]
  15. Expression of the prostate specific antigen gene by lung tissue. Zarghami, N., D'Costa, M., Tsuyuki, D., Asa, S.L., Diamandis, E.P. Clin. Cancer Res. (1997) [Pubmed]
  16. Bone density in asthmatic patients taking high dose inhaled beclomethasone dipropionate and intermittent systemic corticosteroids. Packe, G.E., Douglas, J.G., McDonald, A.F., Robins, S.P., Reid, D.M. Thorax (1992) [Pubmed]
  17. Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older. Williams, B., Noonan, G., Reiss, T.F., Knorr, B., Guerra, J., White, R., Matz, J. Clin. Exp. Allergy (2001) [Pubmed]
  18. A comparison of the effects of oral cetirizine and inhaled beclomethasone on early and late asthmatic responses to allergen and the associated increase in airways hyperresponsiveness. Bentley, A.M., Walker, S., Hanotte, F., De Vos, C., Durham, S.R. Clin. Exp. Allergy (1996) [Pubmed]
  19. Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Niimi, A., Matsumoto, H., Amitani, R., Nakano, Y., Sakai, H., Takemura, M., Ueda, T., Chin, K., Itoh, H., Ingenito, E.P., Mishima, M. Am. J. Med. (2004) [Pubmed]
  20. Iatrogenic Cushing's syndrome due to dexamethasone nasal drops. Kimmerle, R., Rolla, A.R. Am. J. Med. (1985) [Pubmed]
  21. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Johnson, P.R., Black, J.L., Carlin, S., Ge, Q., Underwood, P.A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  22. Inhibition of gelatinase activity in human airway epithelial cells and fibroblasts by dexamethasone and beclomethasone. Carver, J.E., Galloway, W.A., Robinson, C. Br. J. Pharmacol. (1999) [Pubmed]
  23. Inhaled beclomethasone decreases serum osteocalcin in postmenopausal asthmatic women. Puolijoki, H., Liippo, K., Herrala, J., Salmi, J., Tala, E. Bone (1992) [Pubmed]
  24. Once daily fluticasone propionate is as effective for perennial allergic rhinitis as twice daily beclomethasone diproprionate. van As, A., Bronsky, E.A., Dockhorn, R.J., Grossman, J., Lumry, W., Meltzer, E.O., Seltzer, J.M., Rogenes, P.R. J. Allergy Clin. Immunol. (1993) [Pubmed]
  25. Combination Therapy with a Long-Acting beta-Agonist and a Leukotriene Antagonist in Moderate Asthma. Deykin, A., Wechsler, M.E., Boushey, H.A., Chinchilli, V.M., Kunselman, S.J., Craig, T.J., Dimango, E., Fahy, J.V., Kraft, M., Leone, F., Lazarus, S.C., Lemanske, R.F., Martin, R.J., Pesola, G.R., Peters, S.P., Sorkness, C.A., Szefler, S.J. Am. J. Respir. Crit. Care Med. (2007) [Pubmed]
  26. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. Salzman, G.A., Pyszczynski, D.R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  27. A clinical trial of combined cromolyn/beclomethasone treatment for chronic asthma. Toogood, J.H., Jennings, B., Lefcoe, N.M. J. Allergy Clin. Immunol. (1981) [Pubmed]
  28. Relationship between vascular endothelial growth factor and angiopoietin-2 in asthmatics before and after inhaled beclomethasone therapy. Nomura, S., Kanazawa, H., Hirata, K., Iwao, H., Yoshikawa, J. The Journal of asthma : official journal of the Association for the Care of Asthma. (2005) [Pubmed]
  29. Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia. Gupta, G.K., Cole, C.H., Abbasi, S., Demissie, S., Njinimbam, C., Nielsen, H.C., Colton, T., Frantz, I.D. Pediatr. Pulmonol. (2000) [Pubmed]
  30. Inhibition of chemokine production from human airway smooth muscle cells by fluticasone, budesonide and beclomethasone. John, M., Oltmanns, U., Binder, C., Meiners, S., Gellert, K., Chung, K.F., Witt, C. Pulmonary pharmacology & therapeutics. (2004) [Pubmed]
  31. Effects of inhaled HFA beclomethasone on pulmonary function and symptoms in patients with chronic obstructive pulmonary disease. John, M., Bosse, S., Oltmanns, U., Schumacher, A., Witt, C. Respiratory medicine. (2005) [Pubmed]
  32. Coating of oral beclomethasone dipropionate capsules with cellulose acetate phthalate enhances delivery of topically active antiinflammatory drug to the terminal ileum. Levine, D.S., Raisys, V.A., Ainardi, V. Gastroenterology (1987) [Pubmed]
  33. Absence of posterior subcapsular cataracts in young patients treated with inhaled glucocorticoids. Simons, F.E., Persaud, M.P., Gillespie, C.A., Cheang, M., Shuckett, E.P. Lancet (1993) [Pubmed]
  34. Steroid-sparing effect of inhaled lysine acetylsalicylate and furosemide in high-dose beclomethasone-dependent asthma. Bianco, S., Vaghi, A., Robuschi, M., Refini, R.M., Pieroni, M.G., Sestini, P. J. Allergy Clin. Immunol. (1995) [Pubmed]
  35. Effects of long-term use of high-dose inhaled steroids on bone density and calcium metabolism. Boulet, L.P., Giguère, M.C., Milot, J., Brown, J. J. Allergy Clin. Immunol. (1994) [Pubmed]
  36. Influence of inhaled steroids on recovery from occupational asthma after cessation of exposure: an 18-month double-blind crossover study. Malo, J.L., Cartier, A., Côté, J., Milot, J., Leblanc, C., Paquette, L., Ghezzo, H., Boulet, L.P. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
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