Disease relevance of Guided Tissue Regeneration

• Effects of tetracycline HCl conditioning and fibrin-fibronectin system application in the treatment of buccal gingival recession with guided tissue regeneration [1].
• This study evaluated guided tissue regeneration in Class II furcation defects after use of a polylactic acid biodegradable barrier in nine patients with mandibular molar defects [2].
• Locally delivered minocycline and guided tissue regeneration to treat post-juvenile periodontitis. A case report [3].
• Experiences with guided tissue regeneration in the treatment of advanced periodontal disease. A clinical re-entry study. Part I. Vertical, horizontal and horizontal periodontal defects [4].

High impact information on Guided Tissue Regeneration

• A three-layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane for guided tissue regeneration [5].
• Gingival biopsies taken from 10 patients allowing both guided tissue regeneration (test) and conventional flap surgery (control) before and 1 month after the operations were processed and the supernatants were studied by Mc Cord and Fridovich, Flohe and Otting, and Luck methods to measure total SOD and CAT levels respectively [6].
• Self-setting barrier membrane for guided tissue regeneration method: initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions [7].
• Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration [8].
• BACKGROUND AND OBJECTIVE: The aim of this study was to examine the pattern of healing in rat calvarial defects prepared with the erbium-YAG laser, using the "guided tissue regeneration" technique [Dahlin et al., Scand J Plast Reconstr Hand Surg 1990;24: 13-19] [9].

Chemical compound and disease context of Guided Tissue Regeneration

• This multi-center study evaluated guided tissue regeneration (GTR) in Class II furcation defects using a polylactic acid biodegradable barrier in 29 patients with mandibular and maxillary molar defects [10].
• The purpose of this study was to evaluate the clinical outcome of root coverage comparing the coronally positioned flap (CPF) with and without guided tissue regeneration (GTR) using a titanium-reinforced expanded polytetrafluoroethylene barrier in paired gingival recession defects [11].
• These findings show that the treatment of buccal gingival recession using guided tissue regeneration procedure plus tetracycline root demineralization and fibrin-fibronectin glue application results in a consistent and predictable improvement of mucogingival defects [12].
• In 24 patients with advanced periodontitis 38 interproximal intrabony defects were treated by conventional surgery (C; n = 8) or guided tissue regeneration (GTR) using expanded polytetrafluoroethylene (G; n = 17) or Polyglactin 910 barriers (V; n = 13) [13].
• Six patients with buccal gingival recession (4 to 6 mm) were treated by means of the guided tissue regeneration technique utilizing a polyglycolactic membrane (Vicryl) [14].

Biological context of Guided Tissue Regeneration

• OBJECTIVES: Bone formation during guided tissue regeneration is a tightly regulated process involving cells, extracellular matrix and growth factors [15].
• Bone regeneration adjacent to titanium dental implants using guided tissue regeneration: a report of two cases [16].

Anatomical context of Guided Tissue Regeneration

• BACKGROUND: Bacterial contamination of membrane material negatively affects healing after guided tissue regeneration (GTR) procedures; conversely, flap connective tissue integration on barrier material improves the clinical outcomes [17].
• The purpose of this investigation was to determine the ability of human gingival fibroblasts, in vitro, to migrate along a chemotactic gradient over 3 different guided tissue regeneration barrier materials; i.e., polytetrafluoroethylene, polylactic acid, and sterile calcium sulfate [18].
• In this study, a technique based on the principle of guided tissue regeneration was tested for its ability to generate bone tissue around titanium implants [19].
• The histologic findings demonstrated that the coronal extent of the new attachment and new facial bone, 9 months after guided tissue regeneration treatment, were located coronal to the preoperative location, in a root surface previously exposed by a deep, long-standing recession [20].
• Attachment of periodontal ligament cells to chlorhexidine-loaded guided tissue regeneration membranes [21].

Associations of Guided Tissue Regeneration with chemical compounds

• The histological findings in rabbit, concerning the resorption of a new composite hydroxyapatite-polymer membrane used in guided tissue regeneration are reported [22].
• Guided tissue regeneration using a polylactic acid barrier [23].
• Ridge augmentation with titanium screws and guided tissue regeneration: technique and report of a case [24].
• However, there was not a statistically significant difference in the improvement observed between sites treated with guided tissue regeneration in conjunction with tetracycline as compared to membrane placement alone [25].
• Guided tissue regeneration with and without citric acid treatment in vertical osseous defects [26].

Gene context of Guided Tissue Regeneration

• MMP-3 and -8 levels were assessed in this study during the early healing phase following a guided tissue regeneration (GTR) procedure [27].
• In 3 monkeys, acute fenestration-type and chronic intrabony defects were treated with guided tissue regeneration (GTR), enamel matrix proteins (EMD), or coronally repositioned flap surgery (control) [28].
• Application of slow-resorbing collagen membrane to periodontal and peri-implant guided tissue regeneration [29].
• This study compared the clinical effectiveness of a combination therapy consisting of bovine porous bone mineral (BPBM), guided tissue regeneration (GTR), and platelet-rich plasma (PRP) in the regeneration of periodontal intrabony defects in humans [30].
• Periodontal healing following guided tissue regeneration with citric acid and fibronectin application [31].

Analytical, diagnostic and therapeutic context of Guided Tissue Regeneration

• The purpose of this study was to compare clinically and radiographically the effectiveness of guided tissue regeneration (GTR), using a bioabsorbable polylactic acid softened with citric acid ester barrier and commercially available demineralized freeze-dried bone allograft (DFDBA) in the treatment of 2- and 3-wall intrabony defects [32].
• Calcium sulfate can function as a resorbable space filler, a resorbable barrier (compatible with guided tissue regeneration principles) and as a vehicle for controlled-release chemotherapy [33].
• CONCLUSIONS: (1) Guided tissue regeneration (GTR) therapy with or without resorbable hydroxylapatite showed significantly favorable results clinically and radiographically compared to flap debridement alone [34].
• The surgical management comprised augmentation of the maxilla with resorbable hydroxyapatite, in conjunction with a guided tissue regeneration technique and vestibuloplasty [35].

References