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MeSH Review


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Disease relevance of Saguinus

  • The aim of this study was to determine the functional relevance of alpha 4 beta 7 in the pathogenesis of colonic inflammatory disease using the colitic cotton-top tamarin, an animal model of human ulcerative colitis [1].
  • To investigate the functional implications of limited MHC class I diversity in this outbred primate species, we infected five tamarins with influenza virus and defined the CTL epitopes recognized by each individual [2].
  • Cotton-top tamarins (CTTs) with confirmed active colitis were treated with the second generation LTB4 receptor antagonist, SC-53228 ((+)-(S)-7-[3-(2-cyclopropyl-methyl)-3-methoxy-4-[(methylamino) carbonyl]phenoxy]propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2- propanoic acid), 20 mg/kg bodyweight by gavage, twice daily for 56 days [3].
  • Epstein-Barr virus (EBV)-transformed tamarin (Saguinus oedipus) cells (B95-8) were selected for growth in medium with reduced serum and then transferred to serum-free medium which consisted of RPMI 1640 supplemented with insulin, transferrin, and selenium [4].
  • GB virus-B (GBV-B) causes an acute hepatitis in tamarins characterized by increased alanine transaminase levels that quickly return to normal as the virus is cleared [5].

Psychiatry related information on Saguinus


High impact information on Saguinus

  • METHODS: Chronically colitic cotton-top tamarins were given either a cross-reactive monoclonal antibody to human alpha 4 beta 7 or an irrelevant control monoclonal antibody [1].
  • Furthermore, coded sera from 10 tamarins with biopsy-proven inflammation involving colonic intestinal mucosa and in which disease activity was moderate to severe showed ECAC-specific cytotoxicity of 3.6% +/- 1.6% [8].
  • A vaccine derived from the high-molecular-weight glycoprotein (gp340) component of the Epstein-Barr (EB) virus membrane antigen conferred complete protection against a 100% lymphomagenic dose of EB virus in the cottontop tamarin, the animal of choice for experiments with EB virus [9].
  • The cotton-top tamarin was found to have a markedly reduced amount of one mucin component (IV) in a manner analogous to the reduction in a human mucin fraction previously noted in patients with ulcerative colitis [10].
  • Surprisingly, these two tamarins used different MHC class I molecules, Saoe-G*02 and -G*04, to present the M1 epitope [2].

Chemical compound and disease context of Saguinus


Biological context of Saguinus


Anatomical context of Saguinus


Associations of Saguinus with chemical compounds

  • In addition to an immunodominant epitope of the viral nucleoprotein (NP) that was recognized by all individuals, two tamarins also made a response to the same epitope of the matrix (M1) protein [2].
  • Protamine 1 gene sequence from the primate Saguinus imperator isolated with PCR using consensus oligonucleotides [25].
  • The involucrin genes of the white-fronted capuchin and cottontop tamarin: the platyrrhine middle region [26].
  • Circulating bioactive LH and progesterone concentrations and fecal progesterone, pregnanediol, estradiol, and estrone concentrations were measured by collecting blood and daily fecal samples from four captive common marmoset females and four cotton-top tamarin females for 30 days [27].
  • Sexual maturation, or puberty, occurs in female tamarins living with their families between 15 and 17 mo of age when mean LH and E1C levels began to increase [28].

Gene context of Saguinus

  • Classical New World monkey MHC class I genes are all more similar to the nonclassical HLA-G gene and a nonclassical F-like gene is present in the cotton-top tamarin [29].
  • The region between KLK1 and KLK15 is conserved between the cotton-top tamarin and humans, and there are no signs of the extension seen in the mouse [30].
  • We have determined the sequence of CD81 from the tamarin, a primate species known to be refractory to HCV infection [20].
  • The evolution of the glandular kallikrein locus: identification of orthologs and pseudogenes in the cotton-top tamarin [30].
  • Comparison of the proportion of nonsynonymous (pN) and synonymous (pS) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions (CDR1 and CDR2) [31].

Analytical, diagnostic and therapeutic context of Saguinus


  1. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Hesterberg, P.E., Winsor-Hines, D., Briskin, M.J., Soler-Ferran, D., Merrill, C., Mackay, C.R., Newman, W., Ringler, D.J. Gastroenterology (1996) [Pubmed]
  2. Three different MHC class I molecules bind the same CTL epitope of the influenza virus in a primate species with limited MHC class I diversity. Evans, D.T., Knapp, L.A., Jing, P., Piekarczyk, M.S., Hinshaw, V.S., Watkins, D.I. J. Immunol. (1999) [Pubmed]
  3. Oral efficacy of a leukotriene B4 receptor antagonist in colitic cotton-top tamarins. Fretland, D., Sanderson, T., Smith, P., Adams, L., Carson, R., Fuhr, J., Tanner, J., Clapp, N. Gut (1995) [Pubmed]
  4. Growth of B95-8 cells and expression of Epstein-Barr virus lytic phase in serum-free medium. Shaw, J.E., Petit, R.G., Leung, K. J. Virol. (1987) [Pubmed]
  5. Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. Beames, B., Chavez, D., Guerra, B., Notvall, L., Brasky, K.M., Lanford, R.E. J. Virol. (2000) [Pubmed]
  6. Prolactin levels during the periparturitional period in the biparental cotton-top tamarin (Saguinus oedipus): interactions with gender, androgen levels, and parenting. Ziegler, T.E., Wegner, F.H., Carlson, A.A., Lazaro-Perea, C., Snowdon, C.T. Hormones and behavior. (2000) [Pubmed]
  7. Maternal behavior is related to prepartum urinary estradiol levels in red-bellied tamarin monkeys. Pryce, C.R., Abbott, D.H., Hodges, J.K., Martin, R.D. Physiol. Behav. (1988) [Pubmed]
  8. Expression of immune sensitization to epithelial cell-associated components in the cotton-top tamarin: a model of chronic ulcerative colitis. Winter, H.S., Crum, P.M., King, N.W., Sehgal, P.K., Roche, J.K. Gastroenterology (1989) [Pubmed]
  9. Vaccination against Epstein-Barr virus: current progress and future strategies. Epstein, M.A. Lancet (1986) [Pubmed]
  10. Colonic mucin composition in primates. Selective alterations associated with spontaneous colitis in the cotton-top tamarin. Podolsky, D.K., Madara, J.L., King, N., Sehgal, P., Moore, R., Winter, H.S. Gastroenterology (1985) [Pubmed]
  11. Effects of erythromycin and ciprofloxacin on chronic fecal excretion of Campylobacter species in marmosets. Goodman, L.J., Kaplan, R.L., Petrak, R.M., Fliegelman, R.M., Taff, D., Walton, F., Penner, J.L., Trenholme, G.M. Antimicrob. Agents Chemother. (1986) [Pubmed]
  12. Prevention of Epstein-Barr (EB) virus-induced lymphoma in cottontop tamarins by vaccination with the EB virus envelope glycoprotein gp340 incorporated into immune-stimulating complexes. Morgan, A.J., Finerty, S., Lovgren, K., Scullion, F.T., Morein, B. J. Gen. Virol. (1988) [Pubmed]
  13. Toxoplasmosis in golden-headed lion tamarins (Leontopithecus chrysomelas) and emperor marmosets (Saguinus imperator) in captivity. Epiphanio, S., Guimarães, M.A., Fedullo, D.L., Correa, S.H., Catão-Dias, J.L. J. Zoo Wildl. Med. (2000) [Pubmed]
  14. Inflammatory mediator changes in cotton-top tamarins (CTT) after SC-41930 anti-colitic therapy. Clapp, N., Henke, M., Hansard, R., Carson, R., Walsh, R., Widomski, D., Anglin, C., Fretland, D. Agents Actions (1993) [Pubmed]
  15. MHC class I-processed pseudogenes in New World primates provide evidence for rapid turnover of MHC class I genes. Cadavid, L.F., Hughes, A.L., Watkins, D.I. J. Immunol. (1996) [Pubmed]
  16. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. Watkins, D.I., Letvin, N.L., Hughes, A.L., Tedder, T.F. J. Immunol. (1990) [Pubmed]
  17. Specific immune serum to the Epstein-Barr virus DNA polymerase. Petit, R.G., Leung, K., Shaw, J.E. J. Virol. (1987) [Pubmed]
  18. Major-histocompatibility-complex DRB genes of a New-World monkey, the cottontop tamarin (Saguinus oedipus). Grahovac, B., Mayer, W.E., Vincek, V., Figueroa, F., O'hUigin, C., Tichy, H., Klein, J. Mol. Biol. Evol. (1992) [Pubmed]
  19. Semenogelin II gene is replaced by a truncated line 1 repeat in the cotton-top tamarin. Lundwall, A., Olsson, A.Y. Biol. Reprod. (2001) [Pubmed]
  20. Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. Meola, A., Sbardellati, A., Bruni Ercole, B., Cerretani, M., Pezzanera, M., Ceccacci, A., Vitelli, A., Levy, S., Nicosia, A., Traboni, C., McKeating, J., Scarselli, E. J. Virol. (2000) [Pubmed]
  21. Effect of chlorine treatment on infectivity of hepatitis A virus. Peterson, D.A., Hurley, T.R., Hoff, J.C., Wolfe, L.G. Appl. Environ. Microbiol. (1983) [Pubmed]
  22. Fate map of the developing chick face: analysis of expansion of facial primordia and establishment of the primary palate. McGonnell, I.M., Clarke, J.D., Tickle, C. Dev. Dyn. (1998) [Pubmed]
  23. Distribution of human endogenous retrovirus HERV-K genomes in humans and different primates. Steinhuber, S., Brack, M., Hunsmann, G., Schwelberger, H., Dierich, M.P., Vogetseder, W. Hum. Genet. (1995) [Pubmed]
  24. Inhibition of dexamethasone binding to human glucocorticoid receptor by New World primate cell extracts. Brandon, D.D., Kendall, J.W., Alman, K., Tower, P., Loriaux, D.L. Steroids (1995) [Pubmed]
  25. Protamine 1 gene sequence from the primate Saguinus imperator isolated with PCR using consensus oligonucleotides. Queralt, R., Oliva, R. Nucleic Acids Res. (1991) [Pubmed]
  26. The involucrin genes of the white-fronted capuchin and cottontop tamarin: the platyrrhine middle region. Phillips, M., Rice, R.H., Djian, P., Green, H. Mol. Biol. Evol. (1991) [Pubmed]
  27. Metabolism of reproductive steroids during the ovarian cycle in two species of callitrichids, Saguinus oedipus and Callithrix jacchus, and estimation of the ovulatory period from fecal steroids. Ziegler, T.E., Scheffler, G., Wittwer, D.J., Schultz-Darken, N., Snowdon, C.T., Abbott, D.H. Biol. Reprod. (1996) [Pubmed]
  28. The endocrinology of puberty and reproductive functioning in female cotton-top tamarins (Saguinus oedipus) under varying social conditions. Ziegler, T.E., Savage, A., Scheffler, G., Snowdon, C.T. Biol. Reprod. (1987) [Pubmed]
  29. The evolution of major histocompatibility class I genes in primates. Watkins, D.I. Crit. Rev. Immunol. (1995) [Pubmed]
  30. The evolution of the glandular kallikrein locus: identification of orthologs and pseudogenes in the cotton-top tamarin. Olsson, A.Y., Valtonen-André, C., Lilja, H., Lundwall, A. Gene (2004) [Pubmed]
  31. The T-cell receptor beta chain-encoding gene repertoire of a New World primate species, the cotton-top tamarin. Allen, T.M., Lanchbury, J.S., Hughes, A.L., Watkins, D.I. Immunogenetics (1996) [Pubmed]
  32. Hepatitis C virus envelope protein E2 binds to CD81 of tamarins. Allander, T., Forns, X., Emerson, S.U., Purcell, R.H., Bukh, J. Virology (2000) [Pubmed]
  33. Cyclic excretion of urinary oestrogens in female tamarins (Saguinus oedipus). French, J.A., Abbott, D.H., Scheffler, G., Robinson, J.A., Goy, R.W. J. Reprod. Fertil. (1983) [Pubmed]
  34. Validation of urinary cortisol as an indicator of hypothalamic-pituitary-adrenal function in the bearded emperor tamarin (Saguinus imperator subgrisescens). McCallister, J.M., Smith, T.E., Elwood, R.W. Am. J. Primatol. (2004) [Pubmed]
  35. Glandular kallikreins of the cotton-top tamarin: molecular cloning of the gene encoding the tissue kallikrein. Olsson, A.Y., Persson, A.M., Valtonen-André, C., Lundwall , A. DNA Cell Biol. (2000) [Pubmed]
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