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MeSH Review

Eye Infections

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Disease relevance of Eye Infections


High impact information on Eye Infections

  • Treatment of vaccinial eye infection with vidarabine [6].
  • When instilled into the conjunctival sac of guinea pigs that had been previously infected and were immune, viable chlamydiae or a Triton X-100-soluble extract of them produced a short-lived (12-48 hr) eye disease indistinguishable clinically and histologically from that observed during primary chlamydial eye infection [7].
  • To evaluate the anti-HSV-1 mechanisms of murine IFN-beta in ocular infection, mice were transduced with an adenoviral vector expressing murine IFN-beta (Ad:IFN-beta) [8].
  • These results support a critical role for B7/CD28 costimulation in susceptibility to P. aeruginosa ocular infection [9].
  • The data show early induction and continued maintenance of IL-12 (p40) mRNA in the cornea and draining lymph node upon ocular infection with HSV [10].

Chemical compound and disease context of Eye Infections


Biological context of Eye Infections


Anatomical context of Eye Infections

  • The antibacterial efficacy of oral lomefloxacin has been investigated in a wide variety of infections, including respiratory and uncomplicated and complicated urinary tract infections, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections [17].
  • Ophthalmologists should be aware that about 50% of preoperative patients without signs of ocular infection may have bacterial growth on the conjunctiva, and that elderly patients with nasolacrimal duct obstruction, dry eye, and recent hospital stays may be carriers of MRSA or MRCNS [18].

Gene context of Eye Infections

  • The purpose of the present study was to investigate the role of the angiogenic factors macrophage inflammatory protein-2 (MIP-2) and vascular endothelial growth factor (VEGF) in the regulation of corneal neovascularization during P. aeruginosa ocular infection [19].
  • The role of ICAM-2 in P. aeruginosa ocular infection was then addressed through a monoclonal antibody (MAb) blockade of ICAM-2 in infected ICAM-1 KO and WT mice [20].
  • The role of tumor necrosis factor alpha (TNF-alpha)-lymphotoxin signaling in the control of rabies virus ocular infection and inflammatory cell infiltration was assessed using mice lacking the p55 TNF-alpha receptor (p55TNFR(-/-) mice) [3].
  • Neutralizing antibodies to mouse CXCL10 were used to determine the role of CXCL10 during the acute phase of HSV-1 ocular infection [21].
  • In experimental murine eye infections, multiple additions of 5 nM CFTR peptide 103-117 to inocula of either cytotoxic (exoU+) or noncytotoxic P. aeruginosa resulted in large reductions in bacteria in the eye and markedly lessened eye pathology [22].

Analytical, diagnostic and therapeutic context of Eye Infections


  1. Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects. Kim, B., Lee, S., Suvas, S., Rouse, B.T. J. Immunol. (2005) [Pubmed]
  2. Therapeutic immunization with a virion host shutoff-defective, replication-incompetent herpes simplex virus type 1 strain limits recurrent herpetic ocular infection. Keadle, T.L., Morrison, L.A., Morris, J.L., Pepose, J.S., Stuart, P.M. J. Virol. (2002) [Pubmed]
  3. Rabies virus ocular disease: T-cell-dependent protection is under the control of signaling by the p55 tumor necrosis factor alpha receptor, p55TNFR. Camelo, S., Castellanos, J., Lafage, M., Lafon, M. J. Virol. (2001) [Pubmed]
  4. Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits. Kannan, R., Gukasyan, H.J., Zhang, W., Trousdale, M.D., Kim, K.J., Lee, V.H. Free Radic. Biol. Med. (2004) [Pubmed]
  5. Sialic acid functions in enterovirus 70 binding and infection. Alexander, D.A., Dimock, K. J. Virol. (2002) [Pubmed]
  6. Treatment of vaccinial eye infection with vidarabine. Gatenby, P. Lancet (1979) [Pubmed]
  7. Ocular delayed hypersensitivity: a pathogenetic mechanism of chlamydial-conjunctivitis in guinea pigs. Watkins, N.G., Hadlow, W.J., Moos, A.B., Caldwell, H.D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  8. Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta. Al-Khatib, K., Williams, B.R., Silverman, R.H., Halford, W., Carr, D.J. J. Immunol. (2004) [Pubmed]
  9. B7/CD28 costimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice. Hazlett, L.D., McClellan, S., Barrett, R., Rudner, X. J. Immunol. (2001) [Pubmed]
  10. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection. Kanangat, S., Thomas, J., Gangappa, S., Babu, J.S., Rouse, B.T. J. Immunol. (1996) [Pubmed]
  11. Use of acyclovir in herpetic ocular infection. McGill, J., Tormey, P. Am. J. Med. (1982) [Pubmed]
  12. Safety and efficacy of topical norfloxacin versus tobramycin in the treatment of external ocular infections. Jacobson, J.A., Call, N.B., Kasworm, E.M., Dirks, M.S., Turner, R.B. Antimicrob. Agents Chemother. (1988) [Pubmed]
  13. Pseudomonas eye infections in cyclophosphamide-treated mice. Hazlett, L.D., Rosen, D.D., Berk, R.S. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  14. Prevention of herpes keratitis by monoclonal antibodies specific for discontinuous and continuous epitopes on glycoprotein D. Lousch, R.N., Staats, H., Oakes, J.E., Cohen, G.H., Eisenberg, R.J. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  15. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Preston, M.J., Fleiszig, S.M., Zaidi, T.S., Goldberg, J.B., Shortridge, V.D., Vasil, M.L., Pier, G.B. Infect. Immun. (1995) [Pubmed]
  16. Antimicrobial peptides: a potential role in ocular therapy. Aliwarga, Y., Hume, E.B., Lan, J., Willcox, M.D. Clin. Experiment. Ophthalmol. (2001) [Pubmed]
  17. Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Wadworth, A.N., Goa, K.L. Drugs (1991) [Pubmed]
  18. Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci from conjunctivas of preoperative patients. Kato, T., Hayasaka, S. Jpn. J. Ophthalmol. (1998) [Pubmed]
  19. Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice. Xue, M.L., Thakur, A., Willcox, M. Immunol. Cell Biol. (2002) [Pubmed]
  20. Intercellular adhesion molecule-2 (ICAM-2) and Pseudomonas aeruginosa ocular infection. Hobden, J.A. DNA Cell Biol. (2003) [Pubmed]
  21. Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. Carr, D.J., Chodosh, J., Ash, J., Lane, T.E. J. Virol. (2003) [Pubmed]
  22. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Zaidi, T.S., Lyczak, J., Preston, M., Pier, G.B. Infect. Immun. (1999) [Pubmed]
  23. Endogenous Aspergillus endophthalmitis. Clinical features and treatment outcomes. Weishaar, P.D., Flynn, H.W., Murray, T.G., Davis, J.L., Barr, C.C., Gross, J.G., Mein, C.E., McLean, W.C., Killian, J.H. Ophthalmology (1998) [Pubmed]
  24. Efficacy and safety of combined diclofenac 0.1% and gentamicin 0.3% eyedrops after phacoemulsification. Rossetti, L., Bellucci, R., Cillino, S., Monreale, D., Bonomi, L., Ponte, F., Orzalesi, N. Journal of cataract and refractive surgery. (1997) [Pubmed]
  25. Unusual anaerobic bacteria in keratitis after laser in situ keratomileusis: diagnosis using molecular biology methods. Ferrer, C., Rodríguez-Prats, J.L., Abad, J.L., Alió, J.L. Journal of cataract and refractive surgery. (2004) [Pubmed]
  26. Topical tobramycin and gentamicin sulfate in the treatment of ocular infections: multicenter study. Cagle, G., Davis, S., Rosenthal, A., Smith, J. Curr. Eye Res. (1981) [Pubmed]
  27. Candidial osteomyelitis: a case report. Fogarty, M. The Australian and New Zealand journal of surgery. (1983) [Pubmed]
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