Disease relevance of Oncorhynchus keta

• Melanin-concentrating hormone (MCH) was first discovered in the pituitary of chum salmon because of its role in the regulation of skin pallor [1].
• Affinity of this enzyme with arginine tRNA was determine from Vmas/Km values and it was in the order of rabbit, Chum salmon, B. subtilis, E. coli and yeast in both systems [2].

High impact information on Oncorhynchus keta

• Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated from chum salmon pituitaries [3].
• This superfamily currently includes equistatin, major histocompatibility complex class II- associated p41 invariant chain fragment, and chum salmon egg cysteine proteinase inhibitor [4].
• ECI, one of three isoforms of cysteine protease inhibitor found in chum salmon eggs was purified to homogeneity, and its complete amino acid sequence was determined [5].
• A novel cysteine protease inhibitor of the egg of chum salmon, containing a cysteine-rich thyroglobulin-like motif [5].
• Gene structure of chum salmon somatolactin, a presumed pituitary hormone of the growth hormone/prolactin family [6].

Biological context of Oncorhynchus keta

• From a chum salmon genomic DNA library, clones coding for somatolactin (SL), a presumed pituitary hormone belonging to the GH/PRL family, were isolated and analyzed [6].
• Nucleotide sequence of a cloned cDNA for proopiomelanocortin precursor of chum salmon, Onchorynchus keta [7].
• We determined 2162-bp sequences from the mitochondrial genome of the masu salmon Oncorhynchus masou masou, chum salmon Oncorhynchus keta, and Atlantic salmon Salmo salar by using polymerase chain reactions [8].
• Attenuation of diurnal rhythms in plasma levels of melatonin and cortisol, and hypothalamic contents of vasotocin and isotocin mRNAs in pre-spawning chum salmon [9].
• The immunoreactive plasma PRL levels in mature chum salmon were below 1 ng/ml in seawater [10].

Anatomical context of Oncorhynchus keta

• The increase in mRNA of both subunits is probably due to positive feedback of E(2) and testosterone produced by ovarian follicles in response to the GTH contained in chum salmon pituitary homogenate [11].
• A distinct shift of steroidogenic responses of intact follicles from estradiol-17 beta to 17 alpha,20 beta-diOHprog in response to partially purified chum salmon gonadotropin (SGA) occurred immediately prior to oocyte maturation [12].
• Changes in whole body concentrations of cortisol, thyroid hormones, and sex steroids during early development of the chum salmon, Oncorhynchus keta [13].
• Moreover, abundant expression of AANAT and Mel-R mRNAs in the optic tectum, thalamus, hypothalamus, cerebellum, and eye indicates possible roles of melatonin in visual processing and neuroendocrine regulation, through which melatonin might be involved in migratory behavior of chum salmon [14].
• The in vitro biological actions of synthetic chum salmon melanin concentrating hormone (MCH) on melanophores of the blue damselfish (a teleost), Chrysiptera cyanea, were studied [15].

Associations of Oncorhynchus keta with chemical compounds

• Isolation of apolipoproteins from carotenoid-carrying lipoprotein in the serum of chum salmon, Oncorhynchus keta [16].
• We analyzed changes in the hypothalamic levels of vasotocin (VT) and isotocin (IT) mRNA in chum salmon during spawning migration to the Ishikari river [17].
• Molecular cloning of the cDNAs encoding pituitary glycoprotein hormone alpha- and gonadotropin II beta-subunits of the Japanese eel, Anguilla japonica, and increase in their mRNAs during ovarian development induced by injection of chum salmon pituitary homogenate [11].
• Coho salmon GTH I-beta and GTH II-beta differed from each other in amino acid composition, N-terminal amino acids (Gly vs. Ser), and molecular weights in SDS-PAGE (19,000 vs. 20,000) and had a high degree of chemical similarity to chum salmon GTH I-beta and GTH II-beta, respectively [18].
• K+-independent initiation of motility in chum salmon sperm treated with an organic alcohol, glycerol [19].

Gene context of Oncorhynchus keta

• Assignment of disulfide linkages in chum salmon stanniocalcin [20].
• The prolactin (PRL) cells were distributed in the rostral pars distalis and showed specific binding to antisera to carp and chum salmon prolactin [21].
• Structures of cDNAs encoding chum salmon pituitary-specific transcription factor, Pit-1/GHF-1 [22].
• Although the chum salmon contains two non-allelic insulin and IGF-I genes, only one IGF-II gene could be identified [23].
• Heterogeneity of 3' nontranslated regions in proopiomelanocortin (POMC) precursor mRNA of chum salmon Onchorynchus keta: polymorphism of the gene [24].

Analytical, diagnostic and therapeutic context of Oncorhynchus keta

• The distribution of stanniocalcin immunoreactivity was examined in the corpuscles of Stannius of the white sucker (Catostomus commersoni) by using a chum salmon stanniocalcin antiserum, Western blotting, and light and electron microscopy [25].
• This study describes the development of an oncorhynchid growth hormone (GH) radioimmunoassay using recombinant chum salmon GH (rsGH) and a rabbit antiserum (TJK-1) raised against this recombinant material [26].
• Cloning and sequence analyses of cDNAs encoding vasotocin and isotocin precursors of chum salmon, Oncorhynchus keta: evolutionary relationships of neurohypophysial hormone precursors [27].
• Purification and analysis of the major components of chum salmon protamine contained in insulin formulations using high-performance liquid chromatography [28].
• An anionic trypsin from pyloric caeca of chum salmon (Oncorhynchus keta) was purified by ammonium sulfate and acetone fractionation followed by affinity chromatography, gel-filtration, and DEAE-anion exchange chromatography [29].

References