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MeSH Review

Schilling Test

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Disease relevance of Schilling Test


Psychiatry related information on Schilling Test


High impact information on Schilling Test

  • MEASUREMENTS: The modified Schilling test, gastric analysis, serum gastrin level, folate level, and cyanocobalamin level [7].
  • METHODS: Patients were evaluated for clinical history, physical, body composition, nutritional and malabsorptive studies including D-xylose, Schilling test, determinations of 24 h stool fat, weight and nitrogen, and 24 h urea nitrogen [8].
  • Discontinuation of biguanide treatment, or administration of antibiotics, normalized or improved the increased deconjugation of bile acids and the Schilling test [9].
  • Therefore, holo-TC II has been proposed variously as a marker of cobalamin adequacy, cobalamin absorption, or both, including even its advocacy as a surrogate Schilling test [10].
  • In all patients a [14C] glycocholic acid ([14C] G.C.A.) breath test and a "Dicopac" Schilling test were performed to assess terminal ileal function [11].

Chemical compound and disease context of Schilling Test

  • In three different groups of patients presenting severe folate deficiency (purely nutritional folate deficiency, chronic alcoholism or various intestinal diseases), vitamin B12 absorption has been tested by Schilling test in order to investigate the possible effect of folate deficiency on B12 absorption [12].

Biological context of Schilling Test


Anatomical context of Schilling Test


Associations of Schilling Test with chemical compounds

  • Gastrointestinal absorption was evaluated by D-xylose excretion and the Schilling test, as well as serum vitamin [18].
  • A Schilling test and red blood count were done, and serum levels of vitamin B12 and folic acid were determined [19].
  • However, the Schilling test and urinary methylmalonate excretion in this group were normal [20].
  • She had a positive Schilling test which became normal after steroid therapy in spite of persistence of intrinsic factor antibody and depression of serum complement levels [21].
  • Plasma lathosterol levels were significantly elevated in patients with bile acid malabsorption (742 +/- 84 micrograms/ml compared with 400 +/- 59 micrograms/ml in control subjects) and correlated closely with faecal bile acid levels (r = 0.779, P < 0.001), with 75SeHCAT T1/2 (r = -0.524, P < 0.05) and with Schilling test (r = -0.591, P < 0.05) [22].

Gene context of Schilling Test


Analytical, diagnostic and therapeutic context of Schilling Test


  1. Benign gastric ulcer in a patient with pernicious anemia. Manier, J.W., Beltaos, E. Gastroenterology (1975) [Pubmed]
  2. Megaloblastic anemia after gastric bypass for obesity. Crowley, L.V., Olson, R.W. Am. J. Gastroenterol. (1983) [Pubmed]
  3. Function of terminal ileum in patients with Yersinia-triggered reactive arthritis. Saario, R., Leino, R., Lahesmaa, R., Granfors, K., Toivanen, A. J. Intern. Med. (1992) [Pubmed]
  4. Intestinal absorption of vitamin B12 in patients with chronic pancreatic insufficiency and the effect of human duodenal juice on the intestinal uptake of vitamin B12. Von Der Lippe, G., Andersen, K.J., Schjönsby, H. Scand. J. Gastroenterol. (1976) [Pubmed]
  5. Vitamin B12 absorption after ileorectal anastomosis for Crohn's disease: effect of ileal resection and time span after surgery. Behrend, C., Jeppesen, P.B., Mortensen, P.B. European journal of gastroenterology & hepatology. (1995) [Pubmed]
  6. Polyglandular autoimmune syndrome and anorexia nervosa. Kam, T., Birmingham, C.L., Goldner, E.M. The International journal of eating disorders. (1994) [Pubmed]
  7. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Marcuard, S.P., Albernaz, L., Khazanie, P.G. Ann. Intern. Med. (1994) [Pubmed]
  8. Malabsorption and wasting in AIDS patients with microsporidia and pathogen-negative diarrhea. Lambl, B.B., Federman, M., Pleskow, D., Wanke, C.A. AIDS (1996) [Pubmed]
  9. Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Caspary, W.F., Zavada, I., Reimold, W., Deuticke, U., Emrich, D., Willms, B. Diabetologia (1977) [Pubmed]
  10. Influence of cobalamin deficiency compared with that of cobalamin absorption on serum holo-transcobalamin II. Chen, X., Remacha, A.F., Sardà, M.P., Carmel, R. Am. J. Clin. Nutr. (2005) [Pubmed]
  11. A comparison of the structure and function of the terminal ileum in Crohn's disease using radiology, the "Dicopac" Schilling test and [14C] G.C.A. breath test. Glover, S.C., Mowat, N.A. European journal of nuclear medicine. (1978) [Pubmed]
  12. Effect of folate deficiency on vitamin B12 absorption. Cattan, D., Belaiche, J., Zittoun, J., Yvart, J. Ann. Nutr. Metab. (1982) [Pubmed]
  13. Bioavailability of digoxin tablets in patients with gastrointestinal dysfunction. Gerson, C.D., Lowe, E.H., Lindenbaum, J. Am. J. Med. (1980) [Pubmed]
  14. Neuropsychiatric manifestations of vitamin B12 deficiency in the absence of anemia or macrocytosis: a case report. Shanoudy, H., Salem, A.G. South Dakota journal of medicine. (1992) [Pubmed]
  15. Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery. Lindgren, A., Lindstedt, G., Kilander, A.F. J. Intern. Med. (1998) [Pubmed]
  16. Influence of duodenal intrinsic factor on the absorption of labelled vitamin B12. Horányi, M., Gasztonyi, G., Sárfy, E. Acta medica Academiae Scientiarum Hungaricae. (1978) [Pubmed]
  17. Nutritional status, function of the small intestine and jejunal morphology after total gastrectomy for carcinoma of the stomach. Cristallo, M., Braga, M., Agape, D., Primignani, M., Zuliani, W., Vecchi, M., Murone, M., Sironi, M., Di Carlo, V., De Franchis, R. Surgery, gynecology & obstetrics. (1986) [Pubmed]
  18. Preservation of the pylorus in pancreaticoduodenectomy a follow-up evaluation. Traverso, L.W., Longmire, W.P. Ann. Surg. (1980) [Pubmed]
  19. Influence of continent ileal urinary diversion on vitamin B12 absorption. Pannek, J., Haupt, G., Schulze, H., Senge, T. J. Urol. (1996) [Pubmed]
  20. The effect of oral contraceptives on vitamin B12 metabolism. Shojania, A.M., Wylie, B. Am. J. Obstet. Gynecol. (1979) [Pubmed]
  21. Pernicious anemia associated with systemic lupus erythematosus. Korbet, S.M., Corwin, H.L. J. Rheumatol. (1986) [Pubmed]
  22. Plasma lathosterol as a screening test for bile acid malabsorption due to ileal resection: correlation with 75SeHCAT test and faecal bile acid excretion. Färkkilä, M.A., Kairemo, K.J., Taavitsainen, M.J., Strandberg, T.A., Miettinen, T.A. Clin. Sci. (1996) [Pubmed]
  23. Increased sensitivity of the cholylglycine breath test for detecting ileal dysfunction. Hepner, G.W. Gastroenterology (1975) [Pubmed]
  24. Mechanisms of vitamin B12 deficiency in elderly inpatients. Logan, R.F., Elwis, A., Forrest, M.J., Lawrence, A.C. Age and ageing. (1989) [Pubmed]
  25. Use of pancreatic Schilling test to determine efficiency of pancreatic enzyme delivery in pancreatic insufficiency. Brugge, W.R., Goldberg, H.J., Burke, C.A., Depping, B.J. Dig. Dis. Sci. (1988) [Pubmed]
  26. Vitamin B12 malabsorption after jejuno-ileal bypass surgery. Beró, T., Pongrácz, G., Jávor, T. Acta medica Academiae Scientiarum Hungaricae. (1982) [Pubmed]
  27. Vitamin B12 deficiency in patients with urinary intestinal diversion. Terai, A., Okada, Y., Shichiri, Y., Kakehi, Y., Terachi, T., Arai, Y., Yoshida, O. International journal of urology : official journal of the Japanese Urological Association. (1997) [Pubmed]
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