Disease relevance of Rodentia

• Despite the presence of CVO angiotensin receptors in degus and hamsters, it is concluded that the important component of the hypovolemic dipsogenic stimulus in members of these species may be activation of volume receptors rather than brain angiotensin receptors [1].
• Unique alpha-cell crystals, a herpes-like virus, islet amyloidosis, and immunohistochemical reactions of islets are compared in the rodent, Octodon degus, in animals with ordinary and high circulating glucose levels [2].
• Hantavirus strains isolated from rodentia and insectivora in rural China differentiated by polymerase chain reaction assay [3].
• 4. Morphine caused in rat severe hypotension, while doses eight times higher in O. degus had a transient effect [4].
• Investigation on the acute toxic effect of pyrethrum on the blood glucose and of glucose administration on the acute pyrethrum toxicity in Meriones hurrianae Jerdon (Rodentia) [5].

Psychiatry related information on Rodentia

• This suggests that social interactions in O. degus activate a rise in testosterone, supporting the Challenge Hypothesis, and could be considered as partial support of the Social Stress Hypothesis [6].

High impact information on Rodentia

• Oral administration of quercitrin, an inhibitor of aldose reductase, leads to a significant decrease in the accumulation of sorbitol in the lens of diabetic Octodon degus [7].
• Phylogenetic relationships between 32 species of rodents representing 14 subfamilies of Muridae and four subfamilies of Dipodidae were studied using sequences of the nuclear protein-coding genes Lecithin Cholesterol Acyl Transferase (LCAT) and von Willebrand Factor (vWF) [8].
• Monophyly of the order Rodentia inferred from mitochondrial DNA sequences of the genes for 12S rRNA, 16S rRNA, and tRNA-valine [9].
• We now report that a high percentage of the sleep-active (Fos-expressing) VLPO neurons express mRNA for the inhibitory neuropeptide, galanin, in nocturnal rodents (mice and rats), diurnal rodents (degus), and cats [10].
• The von Willebrand factor (vWF) gene has been used to understand the origin and timing of Rodentia evolution in the context of placental phylogeny vWF exon 28 sequences of 15 rodent families and eight non-rodent eutherian clades are analysed with two different molecular dating methods (uniform clock on a linearized tree; quartet dating) [11].

Chemical compound and disease context of Rodentia

• We compared testosterone and cortisol concentrations in male degus (Octodon degus, Rodentia) under laboratory conditions without male social interactions, with data from wild males in nature [6].

Biological context of Rodentia

• Vasopressin in the brain of a desert hibernator, the jerboa (Jaculus orientalis): presence of sexual dimorphism and seasonal variation [12].
• The distribution of vasopressin innervation in the brain of the jerboa (Jaculus orientalis) was investigated, with special attention to sex differences and seasonal variations [12].
• Changes in activity and abundance of renal Na,K-ATPase were evaluated during cold exposure and hibernation of the jerboa Jaculus orientalis by measuring the hydrolytic activity, the number of units and the transport activity of Na,K-ATPase in isolated nephron segments [13].
• Comparative chromosome analysis (R- and C-bands) of two South African murid species, Lemniscomys rosalia and Rhabdomys pumilio (Rodentia, murinae) [14].
• Sex-chromosome pairing through heterochromatin in the African rodent Lemniscomys barbarus (Rodentia, Muridae). A synaptonemal complex study [15].

Anatomical context of Rodentia

• The influence of early postnatal socio-emotional deprivation on the development of tyrosine hydroxylase- and 5-hydroxytryptamine-immunoreactive fiber innervation in the medial prefrontal cortex was quantitatively investigated in the precocial rodent Octodon degus [16].
• Using in situ hybridization, the mRNA levels encoding neuropeptide Y (NPY) was investigated in the arcuate nucleus (ARC) of jerboas under three different states of energy balance [17].
• PPARalpha expression is increased at the mRNA and protein levels in liver and duodenum of jerboa treated for 2 weeks with the peroxisome proliferator (PP) clofibrate [18].
• FSH, testosterone and androstenedione were unaffected by BX, whereas paired testis weights were significantly greater in BX degus compared with shams [19].
• The distribution of neuropeptide FF receptors (NPFF(1) and NPFF(2)) was analyzed throughout the central nervous system of rodents (rat, mouse, Octodon degus, and guinea pig), rabbit, and marmoset monkey brains, representing three orders of mammals [20].

Associations of Rodentia with chemical compounds

• These data indicate a high level of vasopressin in the jerboa brain, which may reflect an adaptation to its harsh bioclimatic environment [12].
• Occurrence of a differential expression of the glyceraldehyde-3-phosphate dehydrogenase gene in muscle and liver from euthermic and induced hibernating jerboa (Jaculus orientalis) [21].
• Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation [22].
• The authors conclude that the rate of recovery from odor-enhanced phase shifts is modulated by activational effects of testosterone in male degus [23].
• The distribution of cells expressing gonadotropin-releasing hormone (GnRH) immunoreactivity was examined in the brain of adult jerboa during two distinct periods of the reproductive cycle [24].

Gene context of Rodentia

• AQP-2 medullary immunolabeling was more abundant in the kidneys of degus captured during summer than those captured during winter [25].
• Nuclear DNA phylogeny of the squirrels (Mammalia: Rodentia) and the evolution of arboreality from c-myc and RAG1 [26].
• Molecular phylogeny and biogeography of woolly flying squirrel (Rodentia: Sciuridae), inferred from mitochondrial cytochrome b gene sequences [27].
• Cytochrome b sequences reveal Acomys minous (Rodentia, Muridae) paraphyly and answer the question about the ancestral karyotype of Acomys dimidiatus [28].
• Induction of the expression of the peroxisome proliferator-activated receptor alpha (PPARalpha) by clofibrate in jerboa tissues [18].

Analytical, diagnostic and therapeutic context of Rodentia

• 2. O. degus shows resistance to methadone in the formalin algesiometric test and EEG [29].
• NAD-linked lactate malate, glycerophosphate, alcohol and nonspecific dehydrogenases, aspartate aminotransferases, and soluble esterases from extracts of tissues of individuals from a wild population of Calomys musculinus (Rodentia, Cricetidae) have been analyzed by means of starch gel electrophoresis and specific staining [30].

References