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Gene Review

Itga2b  -  integrin alpha 2b

Mus musculus

Synonyms: AI172977, CD41, CD41B, GP IIb, GPIIb, ...
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Disease relevance of Itga2b


High impact information on Itga2b


Chemical compound and disease context of Itga2b


Biological context of Itga2b

  • Conservation of the linkage of the murine Itga2b and Itgb3 loci in mouse chromosome 11 [12].
  • CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo [13].
  • Using cells derived from mice homozygous for a null allele of gbIIb we show that the absence of GPIIb has no effect on mast cells with respect to a number of measures of cell growth and differentiation [14].
  • We set out to investigate expression of GPIIb in other hematopoietic cell lineages and, having detected it on mast cells, aimed to determine what possible role it might perform [14].
  • Integrin (alpha)IIb(beta)3 (abbreviated as (alpha)IIb), also known as GPIIb-IIIa or CD41/CD61, is a cell adhesion molecule expressed on cells belonging to the megakaryocytic lineage [15].

Anatomical context of Itga2b


Associations of Itga2b with chemical compounds


Physical interactions of Itga2b

  • In addition, this region of Fn bound specifically to alpha IIb beta 3 on thrombin-stimulated but not resting platelets [20].
  • An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene [21].
  • Upon PAC-1 binding to the surface alphaIIb beta3, which is in the active conformation, FAK became dephosphorylated through a process of PKC-dependent phosphatase activation [22].

Regulatory relationships of Itga2b


Other interactions of Itga2b


Analytical, diagnostic and therapeutic context of Itga2b


  1. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Kostyak, J.C., Naik, U.P. Front. Biosci. (2007) [Pubmed]
  2. Identification of the alpha IIb beta 3 integrin in murine tumor cells. Chen, Y.Q., Gao, X., Timar, J., Tang, D., Grossi, I.M., Chelladurai, M., Kunicki, T.J., Fligiel, S.E., Taylor, J.D., Honn, K.V. J. Biol. Chem. (1992) [Pubmed]
  3. Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3. Gruel, Y., Brojer, E., Nugent, D.J., Kunicki, T.J. J. Exp. Med. (1994) [Pubmed]
  4. Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Ni, H., Papalia, J.M., Degen, J.L., Wagner, D.D. Blood (2003) [Pubmed]
  5. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., Nelson, K.K., Diglio, C.A., Taylor, J.D., Honn, K.V. Cancer Res. (1989) [Pubmed]
  6. Ligand and cation binding are dual functions of a discrete segment of the integrin beta 3 subunit: cation displacement is involved in ligand binding. D'Souza, S.E., Haas, T.A., Piotrowicz, R.S., Byers-Ward, V., McGrath, D.E., Soule, H.R., Cierniewski, C., Plow, E.F., Smith, J.W. Cell (1994) [Pubmed]
  7. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Liu, S., Thomas, S.M., Woodside, D.G., Rose, D.M., Kiosses, W.B., Pfaff, M., Ginsberg, M.H. Nature (1999) [Pubmed]
  8. Integrin tyrosine phosphorylation in platelet signaling. Phillips, D.R., Prasad, K.S., Manganello, J., Bao, M., Nannizzi-Alaimo, L. Curr. Opin. Cell Biol. (2001) [Pubmed]
  9. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Emambokus, N.R., Frampton, J. Immunity (2003) [Pubmed]
  10. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Bougie, D.W., Wilker, P.R., Wuitschick, E.D., Curtis, B.R., Malik, M., Levine, S., Lind, R.N., Pereira, J., Aster, R.H. Blood (2002) [Pubmed]
  11. Correlation between the in vivo efficacy of GPIIb/IIIa receptor antagonists (m7E3, MK-383 and DMP-728) and ex vivo platelet inhibition. Huang, J., Rebello, S.S., Faul, J.D., Lucchesi, B.R. Pharmacology (1999) [Pubmed]
  12. Conservation of the linkage of the murine Itga2b and Itgb3 loci in mouse chromosome 11. Chang, Y.S., Seldin, M.F., Fitzgerald, L.A., Lalley, P.A. Mamm. Genome (1999) [Pubmed]
  13. CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Ferkowicz, M.J., Starr, M., Xie, X., Li, W., Johnson, S.A., Shelley, W.C., Morrison, P.R., Yoder, M.C. Development (2003) [Pubmed]
  14. GPIIb (CD41) integrin is expressed on mast cells and influences their adhesion properties. Berlanga, O., Emambokus, N., Frampton, J. Exp. Hematol. (2005) [Pubmed]
  15. (alpha)IIb Integrin, a novel marker for hemopoietic progenitor cells. Corbel, C., Vaigot, P., Salaün, J. Int. J. Dev. Biol. (2005) [Pubmed]
  16. Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. Rout, U.K., Wang, J., Paria, B.C., Armant, D.R. Dev. Biol. (2004) [Pubmed]
  17. GpIIb/IIIa is the main receptor for initial platelet adhesion to glass and titanium surfaces in contact with whole blood. Broberg, M., Eriksson, C., Nygren, H. J. Lab. Clin. Med. (2002) [Pubmed]
  18. alphaIIbbeta3 biogenesis is controlled by engagement of alphaIIb in the calnexin cycle via the N15-linked glycan. Mitchell, W.B., Li, J., French, D.L., Coller, B.S. Blood (2006) [Pubmed]
  19. A novel anti-platelet monoclonal antibody (3C7) specific for the complex of integrin alpha IIb beta3 inhibits platelet aggregation and adhesion. Chen, P., Sun, C.X., Liu, J.N. J. Biol. Chem. (2005) [Pubmed]
  20. Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin. Bowditch, R.D., Halloran, C.E., Aota, S., Obara, M., Plow, E.F., Yamada, K.M., Ginsberg, M.H. J. Biol. Chem. (1991) [Pubmed]
  21. An Ets/Sp1 interaction in the 5'-flanking region of the megakaryocyte-specific alpha IIb gene appears to stabilize Sp1 binding and is essential for expression of this TATA-less gene. Block, K.L., Shou, Y., Poncz, M. Blood (1996) [Pubmed]
  22. Ligand-mimetic anti-alphaIIb beta3 antibody PAC-1 inhibits tyrosine signaling, proliferation and lung colonization of melanoma cells. Rásó, E., Tóvári, J., Ladányi, A., Varga, N., Tímár, J. Pathol. Oncol. Res. (2005) [Pubmed]
  23. Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Larson, M.K., Watson, S.P. Blood (2006) [Pubmed]
  24. Analysis of hematopoietic stem cell reprogramming with toxigenicity. Marguerie, G., Tronik-Le Roux, D. Stem Cells (1998) [Pubmed]
  25. Prolonged circulation of activated platelets following plasmapheresis. Wun, T., Paglieroni, T., Holland, P. Journal of clinical apheresis. (1994) [Pubmed]
  26. Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Li, W., Ferkowicz, M.J., Johnson, S.A., Shelley, W.C., Yoder, M.C. Stem cells and development. (2005) [Pubmed]
  27. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. Wang, X., Crispino, J.D., Letting, D.L., Nakazawa, M., Poncz, M., Blobel, G.A. EMBO J. (2002) [Pubmed]
  28. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. Massberg, S., Konrad, I., Schürzinger, K., Lorenz, M., Schneider, S., Zohlnhoefer, D., Hoppe, K., Schiemann, M., Kennerknecht, E., Sauer, S., Schulz, C., Kerstan, S., Rudelius, M., Seidl, S., Sorge, F., Langer, H., Peluso, M., Goyal, P., Vestweber, D., Emambokus, N.R., Busch, D.H., Frampton, J., Gawaz, M. J. Exp. Med. (2006) [Pubmed]
  29. PCR cloning and sequence of the murine GPIIb gene promoter. Denarier, E., Martin, F., Martineau, S., Marguerie, G. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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