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Chemical Compound Review

indapamide     4-chloro-N-(2-methyl-2,3- dihydroindol-1...

Synonyms: Indaflex, Natrilix, Bajaten, FLUBEST, IDAMIDE, ...
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Disease relevance of SE 1520

  • The combination of both drugs, PER and IDP, at the same low doses as during monotherapy, resulted in normal levels of arterial pressure and complete normalization of cardiac hypertrophy and arteriolar and capillary myocardial densities [1].
  • Treatment with IDP preserved normal capillary myocardial density but did not significantly lower the blood pressure (BP) (169+/-9 mm Hg) and only slightly reduced the cardiac ventricular hypertrophy: - 14% v untreated HT (P < .05) and +37% v NT (P < .01) [1].
  • The plant extracts of Hypericum triquetrifolium, Ballota undulata, Ruta chalepensis, Ononis natrix, Paronychia argentea and Marrubium vulgare had shown promising antimicrobial activity [2].
  • Indapamide (Natrilix): the agent of choice in the treatment of recurrent renal calculi associated with idiopathic hypercalciuria [3].
  • Indapamide (Natrilix; Servier) is an antihypertensive diuretic which is used at a dose of 2.5 mg/d as first-line single-drug treatment of essential arterial hypertension [4].

High impact information on SE 1520


Biological context of SE 1520


Anatomical context of SE 1520


Associations of SE 1520 with other chemical compounds


Gene context of SE 1520


Analytical, diagnostic and therapeutic context of SE 1520


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  2. Evaluation of antimicrobial activity of selected plant extracts by rapid XTT colorimetry and bacterial enumeration. Al-Bakri, A.G., Afifi, F.U. J. Microbiol. Methods (2007) [Pubmed]
  3. Indapamide (Natrilix): the agent of choice in the treatment of recurrent renal calculi associated with idiopathic hypercalciuria. Martins, M.C., Meyers, A.M., Whalley, N.A., Margolius, L.P., Buys, M.E. British journal of urology. (1996) [Pubmed]
  4. Indapamide: a review. Reyes, A.J., Leary, W.P. S. Afr. Med. J. (1983) [Pubmed]
  5. Snake acetylcholine receptor: cloning of the domain containing the four extracellular cysteines of the alpha subunit. Neumann, D., Barchan, D., Horowitz, M., Kochva, E., Fuchs, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver. te Velde, A.A., Ladiges, N.C., Flendrig, L.M., Chamuleau, R.A. J. Hepatol. (1995) [Pubmed]
  7. Prothrombin-activator (thromboplastin) generation in the blood of water snake (Natrix piscator). Srivastava, V.M., Dube, B., Dube, R.K., Agarwal, G.P. Thromb. Haemost. (1981) [Pubmed]
  8. Ultrastructure of the paraphysis cerebri of the water snake Natrix maura L. Fernández-Llebrez, P., Becerra, J., Marín-Girón, F. J. Comp. Neurol. (1982) [Pubmed]
  9. Isolation and characterization of microsatellite loci in the dice snake (Natrix tessellata). Gautschi, B., Widmer, A., Koella, J. Mol. Ecol. (2000) [Pubmed]
  10. Metabolic effects of testosterone in the chequered water-snake, Natrix piscator. Thapliyal, J.P., Gupta, S.C., Garg, R.K. J. Endocrinol. (1975) [Pubmed]
  11. Thyroid function in adrenaline-induced changes in the intermediary metabolism of the chequered water-snake (Natrix piscator). Gupta, S.C., Thapliyal, J.P. J. Endocrinol. (1982) [Pubmed]
  12. Exploring the origin of egg protein in an oviparous water snake (Natrix maura). Santos, X., Arenas, C., Llorente, G.A., Ruiz, X. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2007) [Pubmed]
  13. Severe Granulomatous Lesions in Several Organs from Eustrongylides Larvae in a Free-ranging Dice Snake, Natrix tessellata. Mihalca, A.D., Fictum, P., Skoric, M., Sloboda, M., K??rvemo, S., Ghira, I., Carlsson, M., Modry, D. Vet. Pathol. (2007) [Pubmed]
  14. The cochlear nuclei of snakes. Miller, M.R. J. Comp. Neurol. (1980) [Pubmed]
  15. Thick caliber projections from brainstem to cerebral cortex in the snakes Thamnophis sirtalis and Natrix sipedon. Ulinski, P.S. Neuroscience (1981) [Pubmed]
  16. Morphological evidence for the presence of two cell types in the ependyma of the subcommissural organ of the snake, Natrix maura. Fernández-Llebrez, P., Pérez-Fígares, J.M., Becerra, J., Pérez, J., Marín-Girón, F. Cell Tissue Res. (1984) [Pubmed]
  17. Chromaffin, small granule-containing and ganglion cells in the adrenal gland of reptiles: A comparative ultrastructural study. Unsicker, K. Cell Tissue Res. (1976) [Pubmed]
  18. Efficacy of Indapamide SR Compared With Enalapril in Elderly Hypertensive Patients With Type 2 Diabetes. Puig, J.G., Marre, M., Kokot, F., Fernandez, M., Jermendy, G., Opie, L., Moyseev, V., Scheen, A., Ionescu-Tirgoviste, C., Saldanha, M.H., Halabe, A., Williams, B., Mion, D., Ruiz, M., Hermansen, K., Tuomilehto, J., Finizola, B., Gallois, Y., Amouyel, P., Ollivier, J.P., Asmar, R. Am. J. Hypertens. (2007) [Pubmed]
  19. Comparison of tissue factor and prostacyclin production by human umbilical vein endothelial cells on Dacron vascular prostheses and Dacron smooth films. Tunstall, A., Eberhart, R.C., Prager, M.D. J. Biomed. Mater. Res. (1994) [Pubmed]
  20. Endothelial cells on Dacron vascular prostheses: adherence, growth, and susceptibility to neutrophils. Tunstall, A., Eberhart, R.C., Prager, M.D. J. Biomed. Mater. Res. (1995) [Pubmed]
  21. Effects of thyroid hormone on the chemical constituents of different tissues of the chequered water-snake, Natrix piscator. Gupta, S.C., Thapliyal, J.P., Garg, R.K. Gen. Comp. Endocrinol. (1975) [Pubmed]
  22. Ultimobranchial body and parathyroid glands of the freshwater snake Natrix piscator in response to vitamin D3 administration. Srivastav, A.K., Rani, L. J. Exp. Zool. (1992) [Pubmed]
  23. The distribution of corticotropin-releasing factor--immunoreactive neurons and nerve fibers in the brain of the snake, Natrix maura. Coexistence with arginine vasotocin and mesotocin. Mancera, J.M., López Avalos, M.D., Pérez-Fígares, J.M., Fernández-Llebrez, P. Cell Tissue Res. (1991) [Pubmed]
  24. Invasive potential and substrate dependence of attachment in the dunning R-3327 rat prostate adenocarcinoma model. Donald, C.D., Montgomery, D.E., Emmett, N., Cooke, D.B. Invasion Metastasis (1998) [Pubmed]
  25. Post-testicular change in the reptile sperm surface with particular reference to the snake, Natrix fasciata. Esponda, P., Bedford, J.M. J. Exp. Zool. (1987) [Pubmed]
  26. Snakes as indicators of environmental contamination: relation of detoxifying enzymes and pesticide residues to species occurrence in three aquatic ecosystems. Stafford, D.P., Plapp, F.W., Fleet, R.R. Arch. Environ. Contam. Toxicol. (1976) [Pubmed]
  27. Heterologous amplification of microsatellite markers from colubroid snakes in European natricines (serpentes: natricinae). Hille, A., Janssen, I.A., Menken, S.B., Schlegel, M., Thorpe, R.S. J. Hered. (2002) [Pubmed]
  28. Effect of parathyroidectomy in the water snake, Natrix piscator. Singh, R., Kar, I. Gen. Comp. Endocrinol. (1979) [Pubmed]
  29. Effect of thyroidectomy, i-thyroxine and temperature on hemopoiesis in the chequered water snake, Natrix piscator. Thapliyal, J.P., Kaur, R.J. Gen. Comp. Endocrinol. (1976) [Pubmed]
  30. A morphological study of the tracheal epithelium of the snake Natrix maura. Pastor, L.M. J. Anat. (1990) [Pubmed]
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