Disease relevance of SE 1520

• The combination of both drugs, PER and IDP, at the same low doses as during monotherapy, resulted in normal levels of arterial pressure and complete normalization of cardiac hypertrophy and arteriolar and capillary myocardial densities [1].
• Treatment with IDP preserved normal capillary myocardial density but did not significantly lower the blood pressure (BP) (169+/-9 mm Hg) and only slightly reduced the cardiac ventricular hypertrophy: - 14% v untreated HT (P < .05) and +37% v NT (P < .01) [1].
• The plant extracts of Hypericum triquetrifolium, Ballota undulata, Ruta chalepensis, Ononis natrix, Paronychia argentea and Marrubium vulgare had shown promising antimicrobial activity [2].
• Indapamide (Natrilix): the agent of choice in the treatment of recurrent renal calculi associated with idiopathic hypercalciuria [3].
• Indapamide (Natrilix; Servier) is an antihypertensive diuretic which is used at a dose of 2.5 mg/d as first-line single-drug treatment of essential arterial hypertension [4].

High impact information on SE 1520

• First, a mouse AcChoR alpha-subunit cDNA probe was used to screen a size-selected snake (Natrix tessellata) genomic library [5].
• The domain of the alpha subunit from Natrix and cobra AcChoR (amino acid residues 119-222), which contains the four extracellular cysteines (128, 142, 192, and 193), was amplified by reverse transcription of mRNA and the polymerase chain reaction and then sequenced [5].
• These activities of hepatocytes while attached to tissue culture plastic were compared to the activity of the cells attached to several extracellular matrix constituents: collagen I and IV, laminin, fibronectin, Engelbreth-Holm-Swarm Natrix and in the presence of Matrigel [6].
• Prothrombin-activator (thromboplastin) generation in the blood of water snake (Natrix piscator) [7].
• Paraphyseal epithelial cells of Natrix maura have been studied with light and electron microscopy [8].

Biological context of SE 1520

• Isolation and characterization of microsatellite loci in the dice snake (Natrix tessellata) [9].
• Metabolic effects of testosterone in the chequered water-snake, Natrix piscator [10].
• Injection of adrenaline in ten daily doses of 100 micrograms each into the chequered water-snake, Natrix piscator, stimulated glycogenolysis and lipid esterification in the liver and lipolysis in the adipose tissue of control snakes [11].
• We have examined the origin of egg protein by means of the analysis of protein content of liver and carcass (skeletal muscle) of the oviparous snake Natrix maura throughout an annual cycle [12].
• During an extensive study regarding the epidemiology of larval Eustrongylides infestation in a free-ranging endangered population of dice snakes (Natrix tessellata) from Histria, Romania, an adult female was euthanized to evaluate pathologic changes [13].

Anatomical context of SE 1520

• The non-burrowers, Natrix and Pituophis, have both small cochlear nuclei and relatively short papillae basilares [14].
• Thick caliber projections from brainstem to cerebral cortex in the snakes Thamnophis sirtalis and Natrix sipedon [15].
• Two different types of ependymal cells were found in the subcommissural organ (SCO) of Natrix maura [16].
• Morphological evidence for the presence of two cell types in the ependyma of the subcommissural organ of the snake, Natrix maura [16].
• Chromaffin, small granule-containing (SGC)-cells, neurons and the innervation of these cells was studied in the adrenal gland of three species of reptiles (Testudo graeca, Lacerta dugesi, Natrix natrix) [17].

Associations of SE 1520 with other chemical compounds

• In this subanalysis of the Natrilix SR versus Enalapril Study in hypertensive Type 2 diabetics with micrOalbuminuRia (NESTOR) study, we have compared the effectiveness of indapamide sustained release (SR) and enalapril in reducing blood pressure and microalbuminuria in patients >/=65 years of age [18].
• The functional capacity of human umbilical vein endothelial cells (HUVEC) grown on Dacron (polyethylene terephthalate; PET) vascular prosthetic material was compared with the function of cells on smooth surfaced PET, tissue culture polystyrene (TCPS), and Natrix-coated TCPS [19].
• Human umbilical vein endothelial cells (HUVEC) on knitted and woven Dacron prostheses were compared with HUVEC on smooth surfaces (tissue culture polystyrene, PET film, and Natrix) with regard to adherence, growth, and susceptibility to injury by neutrophils (PMN) [20].
• Effects of thyroid hormone on the chemical constituents of different tissues of the chequered water-snake, Natrix piscator [21].
• Ultimobranchial body and parathyroid glands of the freshwater snake Natrix piscator in response to vitamin D3 administration [22].

Gene context of SE 1520

• The anatomical distribution of neurons and nerve fibers containing corticotropin-releasing factor (CRF) has been studied in the brain of the snake, Natrix maura, by means of immunocytochemistry using an antiserum against rat CRF [23].
• We investigated the cell-matrix interactions of prostate tumor cells by comparing the invasive ability through reconstructed extracellular matrix and attachment upon EHS NATRIX (natural extracellular matrix), fibronectin, laminin, and collagen Type IV [24].
• Sperm surface changes occurring in the reptile Wolffian duct have been explored with particular references to the snake, Natrix fasciata [25].
• Agkistrodon spp. had several times the NADPH-dependent oxidative detoxifying activity of Natrix spp [26].
• Pesticide detoxifying enzymes and residues of p,p'-DDE and PCB were measured in snakes of two genera collected in three aquatic ecosystems in central Texas. Snake genera were Agkistrodon (water moccasins and copperheads) and Natrix (water snakes) [26].

Analytical, diagnostic and therapeutic context of SE 1520

• As indicated by immunofluorescence, immunoelectrophoresis, and immunodiffusion, epitopes on at least some molecules that bind to spermatozoa or that remain free in the duct fluid are shared with those in other Natrix species, but not in more distant reptiles (turtle, anole lizard), nor chicken, rat, or rabbit [25].
• Five loci were polymorphic (average expected heterozygosity 0.749 for a population of N. natrix in Amsterdam, mean sample size 47.8) and three loci were monomorphic [27].
• Effect of parathyroidectomy in the water snake, Natrix piscator [28].
• Effect of thyroidectomy, i-thyroxine and temperature on hemopoiesis in the chequered water snake, Natrix piscator [29].
• The epithelium of the trachea of the Natrix maura snake was studied by conventional light microscopy and transmission and scanning electron microscopy [30].

References