Gene Review:
NKX3-1 - NK3 homeobox 1
Homo sapiens
Synonyms:
BAPX2, Homeobox protein NK-3 homolog A, Homeobox protein Nkx-3.1, NKX3, NKX3.1, ...
- NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Lei, Q., Jiao, J., Xin, L., Chang, C.J., Wang, S., Gao, J., Gleave, M.E., Witte, O.N., Liu, X., Wu, H. Cancer Cell (2006)
- Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer. Asatiani, E., Huang, W.X., Wang, A., Rodriguez Ortner, E., Cavalli, L.R., Haddad, B.R., Gelmann, E.P. Cancer Res. (2005)
- Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers. Voeller, H.J., Augustus, M., Madike, V., Bova, G.S., Carter, K.C., Gelmann, E.P. Cancer Res. (1997)
- NKX3.1 expression is lost in testicular germ cell tumors. Skotheim, R.I., Korkmaz, K.S., Klokk, T.I., Abeler, V.M., Korkmaz, C.G., Nesland, J.M., Fosså, S.D., Lothe, R.A., Saatcioglu, F. Am. J. Pathol. (2003)
- NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells. Li, X., Guan, B., Maghami, S., Bieberich, C.J. Mol. Cell. Biol. (2006)
- NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity. Bowen, C., Stuart, A., Ju, J.H., Tuan, J., Blonder, J., Conrads, T.P., Veenstra, T.D., Gelmann, E.P. Cancer Res. (2007)
- Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function. Zheng, S.L., Ju, J.H., Chang, B.L., Ortner, E., Sun, J., Isaacs, S.D., Sun, J., Wiley, K.E., Liu, W., Zemedkun, M., Walsh, P.C., Ferretti, J., Gruschus, J., Isaacs, W.B., Gelmann, E.P., Xu, J. Cancer Res. (2006)
- Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens. Korkmaz, K.S., Korkmaz, C.G., Ragnhildstveit, E., Kizildag, S., Pretlow, T.G., Saatcioglu, F. Gene (2000)
- Effects of 9-cis retinoic acid on human homeobox gene NKX3.1 expression in prostate cancer cell line LNCaP. Jiang, A.L., Zhang, P.J., Chen, W.W., Liu, W.W., Yu, C.X., Hu, X.Y., Zhang, X.Q., Zhang, J.Y. Asian J. Androl. (2006)
- The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor. Yoon, H.G., Wong, J. Mol. Endocrinol. (2006)
- Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Bowen, C., Bubendorf, L., Voeller, H.J., Slack, R., Willi, N., Sauter, G., Gasser, T.C., Koivisto, P., Lack, E.E., Kononen, J., Kallioniemi, O.P., Gelmann, E.P. Cancer Res. (2000)
- A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. He, W.W., Sciavolino, P.J., Wing, J., Augustus, M., Hudson, P., Meissner, P.S., Curtis, R.T., Shell, B.K., Bostwick, D.G., Tindall, D.J., Gelmann, E.P., Abate-Shen, C., Carter, K.C. Genomics (1997)
- The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor. Carson, J.A., Fillmore, R.A., Schwartz, R.J., Zimmer, W.E. J. Biol. Chem. (2000)
- Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathways. Pu, Y., Huang, L., Birch, L., Prins, G.S. Endocrinology (2007)
- Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function. Gelmann, E.P., Steadman, D.J., Ma, J., Ahronovitz, N., Voeller, H.J., Swope, S., Abbaszadegan, M., Brown, K.M., Strand, K., Hayes, R.B., Stampfer, M.J. Cancer Res. (2002)
- DNA-binding sequence of the human prostate-specific homeodomain protein NKX3.1. Steadman, D.J., Giuffrida, D., Gelmann, E.P. Nucleic Acids Res. (2000)
- Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor. Ju, J.H., Maeng, J.S., Zemedkun, M., Ahronovitz, N., Mack, J.W., Ferretti, J.A., Gelmann, E.P., Gruschus, J.M. J. Mol. Biol. (2006)
- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line. Jiang, A., Yu, C., Zhang, P., Chen, W., Liu, W., Hu, X., Zhang, J. Exp. Mol. Med. (2006)
- Up-regulation of NKX3.1 expression and inhibition of LNCaP cell proliferation induced by an inhibitory element decoy. Jiang, A.L., Hu, X.Y., Zhang, P.J., He, M.L., Kong, F., Liu, Z.F., Yuan, H.Q., Zhang, J.Y. Acta Biochim. Biophys. Sin. (Shanghai) (2005)
- NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Chen, H., Nandi, A.K., Li, X., Bieberich, C.J. Cancer Res. (2002)
- Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells. He, M.L., Yuan, H.Q., Jiang, A.L., Gong, A.Y., Chen, W.W., Zhang, P.J., Young, C.Y., Zhang, J.Y. Cancer (2006)
- The role of estrogens in normal and abnormal development of the prostate gland. Prins, G.S., Huang, L., Birch, L., Pu, Y. Ann. N. Y. Acad. Sci. (2006)
- Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis. Korkmaz, C.G., Korkmaz, K.S., Manola, J., Xi, Z., Risberg, B., Danielsen, H., Kung, J., Sellers, W.R., Loda, M., Saatcioglu, F. J. Urol. (2004)