Disease relevance of Optic Neuropathy, Ischemic

• Interaction of heritable and estrogen-induced thrombophilia: possible etiologies for ischemic optic neuropathy and ischemic stroke [1].
• Absolute fluorescein filling defects occurred only in patients with open-angle glaucoma and sectorial ischemic optic neuropathy [2].
• The development of anterior ischemic optic neuropathy was associated with prolonged cardiopulmonary bypass time, low hematocrit levels, excessive perioperative body weight gain, and the use of epinephrine and amrinone [3].
• Temporal arteritis is an insidious disease which, if not recognized and treated with high-dosage oral prednisone or intravenous prednisolone, can result in unilateral or even total blindness due to anterior ischemic optic neuropathy (AION) or closure of the central artery of the retina [4].
• PURPOSE: To report nonarteric anterior ischemic optic neuropathy (NAION) as an ocular manifestation in a woman with combined primary antiphospholipid syndrome and Factor V Leiden (FVL) mutation [5].

Psychiatry related information on Optic Neuropathy, Ischemic

• Seven patients, aged between 50 and 69 years, had typical features of nonarteritic anterior ischemic optic neuropathy (NAION) within 36 hours after ingestion of sildenafil citrate (Viagra) for erectile dysfunction [6].

High impact information on Optic Neuropathy, Ischemic

• The patient may have had ischemic optic neuropathy concomitant with hypoparathyroidism or caused by tetanic vasospasm or calcification of optic nerve nutrient vessels [7].
• The purpose of this study was to investigate the changes occurring in the retina and optic nerve (ON) in anterior ischemic optic neuropathy (AION), using a c-fos transgenic mouse model [8].
• Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene [9].
• OBJECTIVE: To evaluate the association between platelet glycoprotein polymorphisms and the risks of single and second eye involvement with nonarteritic anterior ischemic optic neuropathy (NAION) [9].
• Ischemic optic neuropathy as the first manifestation of elevated cholesterol levels in young patients [10].

Chemical compound and disease context of Optic Neuropathy, Ischemic

• Sildenafil-associated nonarteritic anterior ischemic optic neuropathy [11].
• PURPOSE: To describe the clinical features of five patients who developed nonarteritic anterior ischemic optic neuropathy (NAION) after ingestion of sildenafil citrate (Viagra; Pfizer Pharmaceuticals, New York, NY) [11].
• Levodopa may improve vision loss in recent-onset, nonarteritic anterior ischemic optic neuropathy [12].
• ACE and angiotensin II and nonarteritic anterior ischemic optic neuropathy [13].
• Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy [14].

Biological context of Optic Neuropathy, Ischemic

• Vasoconstriction secondary to oxymetazoline use may precipitate anterior ischemic optic neuropathy [15].
• PURPOSE: To describe a patient with bilateral non-arteritic anterior ischemic optic neuropathy (NAION) and idiopathic autoimmune thrombocytopenia (ITP) with an extremely low platelet count [16].

Anatomical context of Optic Neuropathy, Ischemic

• A patient with arteriosclerosis, diabetes mellitus, and giant cell arteritis (GCA) treated continuously with low-dose prednisone developed anterior ischemic optic neuropathy (AION) at 5 and 13 months after clinical diagnosis of GCA [17].
• DISCUSSION: Peri- and postoperative posterior ischemic optic neuropathy is a rare but devastating complication of surgery performed at distance from the visual pathways and its vascularization [18].

Gene context of Optic Neuropathy, Ischemic

• Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation [19].
• CONCLUSIONS: Renal dialysis can render patients hypotensive, and this may be associated with anterior ischemic optic neuropathy [20].
• Nonarteritic anterior ischemic optic neuropathy (NAION), a form of optic nerve stroke, has received attention as the result of a possible rare association with PDE5 inhibitors (PDE5i) [21].
• Only six other cases of peri-operative ischemic optic neuropathy have been reported in patients aged less than 30 years, all but one occurring after spinal surgery [22].
• Anterior ischemic optic neuropathy occurring in a patient treated with IFN is a probable complication of the therapy [23].

Analytical, diagnostic and therapeutic context of Optic Neuropathy, Ischemic

• The following variables were studied: demographics, injury severity (Injury Severity Score, highest lactate, worst base deficit, and lowest pH) crystalloid and transfusion requirements, ventilator requirements (PEEP) RESULTS: Of the 350 patients with massive resuscitation, 9 patients were diagnosed with anterior ischemic optic neuropathy (2.6%) [24].
• Indocyanine green versus fluorescein angiography in the differential diagnosis of arteritic and nonarteritic anterior ischemic optic neuropathy [25].
• A 51-year-old white man presented with an acute bilateral anterior ischemic optic neuropathy approximately 1 month following hospitalization for a hyperosmolar nonketotic diabetic coma [26].

References