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MeSH Review


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Disease relevance of Leukostasis


High impact information on Leukostasis

  • Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis [6].
  • A case of fatal radiographic contrast medium (RCM)-induced pulmonary granulocyte aggregation (leukostasis) showed massive elevation of the postmortem histamine level [6].
  • ICAM-1 blockade with a mAb prevents diabetic retinal leukostasis and vascular leakage by 48.5% and 85.6%, respectively [7].
  • In the model of pulmonary leukostasis, the presence of omega-oxidation products of LTB4 indicated metabolic integrity of the trapped PMNs [8].
  • Pulmonary histology in rabbits and sheep confirmed the presence of intracapillary leukostasis after the plasma infusions, whether or not sulfinpyrazone had been administered previously [9].

Chemical compound and disease context of Leukostasis

  • Pretreatment with gadolinium chloride (GdCl3), which reduces KC function, attenuated the liver leukostasis and NPS elicited by gut I/R [10].
  • The platelet activating factor (PAF) antagonist, WEB2086, and a tumor necrosis factor (TNF)-alpha-specific antibody were also effective in attenuating the gut I/R-induced leukostasis and NAD(P)H autofluorescence [10].
  • In the model of pulmonary leukostasis, no nonenzymatic LTA4-derivatives were detected, coincident with a predominance of cysteinyl-LT [11].
  • In diabetic rats, treatment with the antioxidant alpha-lipoic acid normalized the amount of leukostasis but not retinal blood flow [12].
  • In contrast, treatment with D-alpha-tocopherol and protein kinase-C beta-isoform inhibition (LY333531) prevented the increases in leukostasis and decreases in retinal blood flow in diabetic rats [12].

Biological context of Leukostasis


Anatomical context of Leukostasis


Gene context of Leukostasis


Analytical, diagnostic and therapeutic context of Leukostasis


  1. Purified human plasma kallikrein aggregates human blood neutrophils. Schapira, M., Despland, E., Scott, C.F., Boxer, L.A., Colman, R.W. J. Clin. Invest. (1982) [Pubmed]
  2. Enhanced renal allograft rejection by inhibitors of nitric oxide synthase: a nonimmunologic influence on alloreactivity. Stojanovic, T., Gröne, H.J., Gieseler, R.K., Klanke, B., Schlemminger, R., Tsikas, D., Gröne, E.F. Lab. Invest. (1996) [Pubmed]
  3. The irreplaceable image: Cerebral leukostasis manifesting as multifocal intracerebral hemorrhage. Chim, C.S., Ooi, C.G. Haematologica (2001) [Pubmed]
  4. High-voltage irradiation and hydroxyurea for pulmonary leukostasis in acute myelomonocytic leukemia. von Eyben, F.E., Siddiqui, M.Z., Spanos, G. Acta Haematol. (1987) [Pubmed]
  5. Bacteremic and leukopenic pneumococcal pneumonia: successful treatment with antibiotics, pulse steroid, and continuous hemodiafiltration. Yokoyama, T., Sakamoto, T., Shida, N., Shimada, T., Kaku, N., Aizawa, H., Oizumi, K. J. Infect. Chemother. (2002) [Pubmed]
  6. Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis. Schneiderman, H., Hammerschmidt, D.E., McCall, A.R., Jacob, H.S. JAMA (1983) [Pubmed]
  7. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Miyamoto, K., Khosrof, S., Bursell, S.E., Rohan, R., Murata, T., Clermont, A.C., Aiello, L.P., Ogura, Y., Adamis, A.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer. Grimminger, F., Menger, M., Becker, G., Seeger, W. Blood (1988) [Pubmed]
  9. Pulmonary leukostasis and its relationship to pulmonary dysfunction in sheep and rabbits. Fountain, S.W., Martin, B.A., Musclow, C.E., Cooper, J.D. Circ. Res. (1980) [Pubmed]
  10. Role of Kupffer cells in gut ischemia/reperfusion-induced hepatic microvascular dysfunction in mice. Horie, Y., Wolf, R., Russell, J., Shanley, T.P., Granger, D.N. Hepatology (1997) [Pubmed]
  11. Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. Grimminger, F., Kreusler, B., Schneider, U., Becker, G., Seeger, W. J. Immunol. (1990) [Pubmed]
  12. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Abiko, T., Abiko, A., Clermont, A.C., Shoelson, B., Horio, N., Takahashi, J., Adamis, A.P., King, G.L., Bursell, S.E. Diabetes (2003) [Pubmed]
  13. Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Miyamoto, K., Khosrof, S., Bursell, S.E., Moromizato, Y., Aiello, L.P., Ogura, Y., Adamis, A.P. Am. J. Pathol. (2000) [Pubmed]
  14. Hydroxyurea in the prevention of the effects of leukostasis in acute leukemia. Grund, F.M., Armitage, J.O., Burns, P. Arch. Intern. Med. (1977) [Pubmed]
  15. Antisense intercellular adhesion molecule-1 (ICAM-1) oligodeoxyribonucleotide delivered during organ preservation inhibits posttransplant ICAM-1 expression and reduces primary lung isograft failure. Toda, K., Kayano, K., Karimova, A., Naka, Y., Fujita, T., Minamoto, K., Wang, C.Y., Pinsky, D.J. Circ. Res. (2000) [Pubmed]
  16. Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. Kinoshita, N., Kakehashi, A., Inoda, S., Itou, Y., Kuroki, M., Yasu, T., Kawakami, M., Kanazawa, Y. Diabetologia (2002) [Pubmed]
  17. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Barouch, F.C., Miyamoto, K., Allport, J.R., Fujita, K., Bursell, S.E., Aiello, L.P., Luscinskas, F.W., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  18. Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Vollmar, B., Glasz, J., Menger, M.D., Messmer, K. Surgery (1995) [Pubmed]
  19. Stimulated leukocyte adhesion in coronary microcirculation is reduced by a calcium antagonist. McDonagh, P.F., Rauzzino, M.J. Am. J. Physiol. (1993) [Pubmed]
  20. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. Okada, M., Yan, S.F., Pinsky, D.J. FASEB J. (2002) [Pubmed]
  21. VEGF increases retinal vascular ICAM-1 expression in vivo. Lu, M., Perez, V.L., Ma, N., Miyamoto, K., Peng, H.B., Liao, J.K., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  22. Endothelial activation antigens in pulmonary leukostasis in leukemia. van Buchem, M.A., Hogendoorn, P.C., Bruijn, J.A., Kluin, P.M. Acta Haematol. (1993) [Pubmed]
  23. Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature. Stoelcker, B., Ruhland, B., Hehlgans, T., Bluethmann, H., Luther, T., Männel, D.N. Am. J. Pathol. (2000) [Pubmed]
  24. Hepatic microvascular responses to ischemia-reperfusion in low-density lipoprotein receptor knockout mice. Mori, N., Horie, Y., Nimura, Y., Wolf, R., Granger, D.N. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  25. VEGF164 is proinflammatory in the diabetic retina. Ishida, S., Usui, T., Yamashiro, K., Kaji, Y., Ahmed, E., Carrasquillo, K.G., Amano, S., Hida, T., Oguchi, Y., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  26. Pretreatment with pentoxifylline improves the hemodynamic and histologic changes and decreases neutrophil adhesiveness in a pig fecal peritonitis model. Tighe, D., Moss, R., Hynd, J., Boghossian, S., al-Saady, N., Heath, M.F., Bennett, E.D. Crit. Care Med. (1990) [Pubmed]
  27. Treatment of acute promyelocytic leukemia with all-trans retinoic acid: successful control of hyperleukocytosis and leukostasis syndrome with leukaphereses and hydroxyurea. Hwang, W.L., Gau, J.P., Chen, M.C., Young, J.H. Am. J. Hematol. (1993) [Pubmed]
  28. Human recombinant interleukin-2 provokes acute pulmonary vascular endothelial injury in rabbits. Goldblum, S.E., Yoneda, K., Cibull, M., Pearson, T., Hall, C., Marshall, M.E. Journal of biological response modifiers. (1990) [Pubmed]
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