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Chemical Compound Review

KST-1A0004     (2S)-2,5,7,8-tetramethyl-2- [(4R,8S)-4,8,12...

Synonyms: AC1L1LNL, AC1Q7AUT, CTK8E0259, ZINC03871494, AR-1A3175
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Disease relevance of alpha-Tocopherol


Psychiatry related information on alpha-Tocopherol


High impact information on alpha-Tocopherol


Chemical compound and disease context of alpha-Tocopherol


Biological context of alpha-Tocopherol


Anatomical context of alpha-Tocopherol


Associations of alpha-Tocopherol with other chemical compounds


Gene context of alpha-Tocopherol

  • These findings suggested that D-alpha-tocopherol can prevent the activation of PKC in the vascular cells and aorta induced by hyperglycemia by normalizing the elevated levels of DAG [3].
  • By immunoblotting studies, D-alpha-tocopherol treatment was able to reduce the enhancement of PKC beta II isoform in the membraneous fraction isolated from ASMCs [21].
  • Both probucol and D-alpha-tocopherol inhibit the phorbol ester-induced release of IL-1 beta without altering differentiation [22].
  • Molecular dissection of the pathway in plants is now complete with the cloning and characterization of the gene for Arabidopsis MPBQ/MSBQ methyltransferase (VITAMIN E 3; VTE3) [23].
  • Various treatments including i.p. injections of 40 micrograms of Na2SeO3 and 100 mumol of GSH and/or topical applications of 40 mumol of D-alpha-tocopherol (vitamin E) 20 or 15 min, respectively, before tumor promoter treatment inhibited in an additive manner the effects of either TPA or mezerein on both GSH peroxidase activity and ODC induction [24].

Analytical, diagnostic and therapeutic context of alpha-Tocopherol


  1. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Houglum, K., Venkataramani, A., Lyche, K., Chojkier, M. Gastroenterology (1997) [Pubmed]
  2. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. Buck, M., Chojkier, M. EMBO J. (1996) [Pubmed]
  3. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Kunisaki, M., Fumio, U., Nawata, H., King, G.L. Diabetes (1996) [Pubmed]
  4. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Abiko, T., Abiko, A., Clermont, A.C., Shoelson, B., Horio, N., Takahashi, J., Adamis, A.P., King, G.L., Bursell, S.E. Diabetes (2003) [Pubmed]
  5. Trial of d-alpha-tocopherol in Huntington's disease. Peyser, C.E., Folstein, M., Chase, G.A., Starkstein, S., Brandt, J., Cockrell, J.R., Bylsma, F., Coyle, J.T., McHugh, P.R., Folstein, S.E. The American journal of psychiatry. (1995) [Pubmed]
  6. The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. Devaraj, S., Li, D., Jialal, I. J. Clin. Invest. (1996) [Pubmed]
  7. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. Lee, K.S., Buck, M., Houglum, K., Chojkier, M. J. Clin. Invest. (1995) [Pubmed]
  8. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation. Houglum, K., Brenner, D.A., Chojkier, M. J. Clin. Invest. (1991) [Pubmed]
  9. High glucose reduces specific binding for D-alpha-tocopherol in cultured aortic endothelial cells. Kunisaki, M., Umeda, F., Yamauchi, T., Masakado, M., Nawata, H. Diabetes (1993) [Pubmed]
  10. HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism. Storch, A., Ludolph, A.C., Schwarz, J. Neurochem. Int. (1999) [Pubmed]
  11. Protective effects of vitamin E forms (alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina. Aydemir, O., Celebi, S., Yilmaz, T., Yekeler, H., Kükner, A.S. International ophthalmology (2004) [Pubmed]
  12. Modulation of the endogenous leukotriene production by fish oil and vitamin E. Denzlinger, C., Kless, T., Sagebiel-Kohler, S., Lemmen, C., Jacob, K., Wilmanns, W., Adam, O. Journal of lipid mediators and cell signalling. (1995) [Pubmed]
  13. d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Tasinato, A., Boscoboinik, D., Bartoli, G.M., Maroni, P., Azzi, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. Koya, D., Lee, I.K., Ishii, H., Kanoh, H., King, G.L. J. Am. Soc. Nephrol. (1997) [Pubmed]
  15. Role of oxygen radicals in 12-O-tetradecanoylphorbol-13-acetate-induced squamous differentiation of cultured normal human bronchial epithelial cells. Gabrielson, E.W., Rosen, G.M., Grafstrom, R.C., Strauss, K.E., Miyashita, M., Harris, C.C. Cancer Res. (1988) [Pubmed]
  16. Tocopheroxyl radical persistence and tocopherol consumption in liposomes and in vitamin E-enriched rat liver mitochondria and microsomes. Mehlhorn, R.J., Sumida, S., Packer, L. J. Biol. Chem. (1989) [Pubmed]
  17. Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate. Perchellet, J.P., Abney, N.L., Thomas, R.M., Perchellet, E.M., Maatta, E.A. Cancer Res. (1987) [Pubmed]
  18. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Liu, M., Wallmon, A., Olsson-Mortlock, C., Wallin, R., Saldeen, T. Am. J. Clin. Nutr. (2003) [Pubmed]
  19. Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation. Brown, K.M., Morrice, P.C., Duthie, G.G. Am. J. Clin. Nutr. (1997) [Pubmed]
  20. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Serbinova, E., Kagan, V., Han, D., Packer, L. Free Radic. Biol. Med. (1991) [Pubmed]
  21. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Kunisaki, M., Bursell, S.E., Umeda, F., Nawata, H., King, G.L. Diabetes (1994) [Pubmed]
  22. Inhibition of IL-1 beta expression in THP-1 cells by probucol and tocopherol. Akeson, A.L., Woods, C.W., Mosher, L.B., Thomas, C.E., Jackson, R.L. Atherosclerosis (1991) [Pubmed]
  23. From Arabidopsis to agriculture: engineering improved Vitamin E content in soybean. Sattler, S.E., Cheng, Z., DellaPenna, D. Trends Plant Sci. (2004) [Pubmed]
  24. Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin. Perchellet, J.P., Abney, N.L., Thomas, R.M., Guislain, Y.L., Perchellet, E.M. Cancer Res. (1987) [Pubmed]
  25. Pretreatment of young pigs with vitamin E attenuates the elevation in plasma interleukin-6 and cortisol caused by a challenge dose of lipopolysaccharide. Webel, D.M., Mahan, D.C., Johnson, R.W., Baker, D.H. J. Nutr. (1998) [Pubmed]
  26. The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels. Martin, L., Wilson, C.G., Koosha, F., Tetley, L., Gray, A.I., Senel, S., Uchegbu, I.F. Journal of controlled release : official journal of the Controlled Release Society. (2002) [Pubmed]
  27. Pharmacokinetics and tissue uptake of D-alpha-tocopherol in sheep following a single intraperitoneal injection. Toutain, P.L., Hidiroglou, M., Charmley, E. J. Dairy Sci. (1995) [Pubmed]
  28. Acute treatment with vitamin E does not protect the regionally ischemic, reperfused porcine heart. Klein, H.H., Pich, S., Nebendahl, K., Niedmann, P., Schuff-Werner, P. Basic Res. Cardiol. (1991) [Pubmed]
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