Chemical Compound Review:
Freedox (8S,10R,13S,14S,16R,17S)-17- [2-[4-(2,6...
Synonyms:
Freedox (TN), AC1L2XOW, U-74006F, D01930, U74006F, ...
This record was replaced with 104903.
- Protective effect of the lazaroid U74006F in cold ischemia-reperfusion injury of the liver. Cosenza, C.A., Cramer, D.V., Cunneen, S.A., Tuso, P.J., Wang, H.K., Makowka, L. Hepatology (1994)
- Effect of U74006F on forebrain ischemia in rats. Lesiuk, H., Sutherland, G., Peeling, J., Butler, K., Saunders, J. Stroke (1991)
- Pretreatment with U74006F improves neurologic outcome following complete cerebral ischemia in dogs. Perkins, W.J., Milde, L.N., Milde, J.H., Michenfelder, J.D. Stroke (1991)
- Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. Gaetani, P., Marzatico, F., Lombardi, D., Adinolfi, D., Rodriguez y Baena, R. Stroke (1991)
- Effects of U74006F on multifocal cerebral blood flow and metabolism after cardiac arrest in dogs. Sterz, F., Safar, P., Johnson, D.W., Oku, K., Tisherman, S.A. Stroke (1991)
- Effects of lazaroids and a peroxynitrite scavenger in a cell model of peroxynitrite toxicity. Fici, G.J., Althaus, J.S., VonVoigtlander, P.F. Free Radic. Biol. Med. (1997)
- Failure of the lipid peroxidation inhibitor, U74006F, to prevent postischemic selective neuronal injury. Buchan, A.M., Bruederlin, B., Heinicke, E., Li, H. J. Cereb. Blood Flow Metab. (1992)
- Tirilazad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia. Maruki, Y., Koehler, R.C., Kirsch, J.R., Blizzard, K.K., Traystman, R.J. J. Cereb. Blood Flow Metab. (1995)
- Correlation between attenuation of posttraumatic spinal cord ischemia and preservation of tissue vitamin E by the 21-aminosteroid U74006F: evidence for an in vivo antioxidant mechanism. Hall, E.D., Yonkers, P.A., Horan, K.L., Braughler, J.M. J. Neurotrauma (1989)
- Attenuation of renal reperfusion injury in rats by the 21-aminosteroid U74006F. Stanley, J.J., Goldblum, J.R., Frank, T.S., Zelenock, G.B., D'Alecy, L.G. J. Vasc. Surg. (1993)
- Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F. Hall, E.D., Yonkers, P.A. Stroke (1988)
- Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. Maruki, Y., Koehler, R.C., Kirsch, J.R., Blizzard, K.K., Traystman, R.J. Stroke (1993)
- Protective effect of a 21-aminosteroid on the blood-brain barrier following subarachnoid hemorrhage in rats. Zuccarello, M., Anderson, D.K. Stroke (1989)
- The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. Liu, P., Vonderfecht, S.L., McGuire, G.M., Fisher, M.A., Farhood, A., Jaeschke, H. J. Pharmacol. Exp. Ther. (1994)
- 21-Aminosteroid reduces ion shifts and edema in the rat middle cerebral artery occlusion model of regional ischemia. Young, W., Wojak, J.C., DeCrescito, V. Stroke (1988)
- Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells. Audus, K.L., Guillot, F.L., Braughler, J.M. Free Radic. Biol. Med. (1991)
- Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils. Hall, E.D., Pazara, K.E., Braughler, J.M. Stroke (1991)
- 21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers. Shi, F., Cavitt, J., Audus, K.L. Free Radic. Biol. Med. (1995)
- Nonsteroidal lazaroid U78517F in models of focal and global ischemia. Hall, E.D., Pazara, K.E., Braughler, J.M., Linseman, K.L., Jacobsen, E.J. Stroke (1990)
- Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury. Sato, P.H., Hall, E.D. J. Neurochem. (1992)
- Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases. Youdim, M.B., Fridkin, M., Zheng, H. Journal of neural transmission (Vienna, Austria : 1996) (2004)
- Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis. Salahudeen, A., Wang, C., McDaniel, O., Lagoo-Denadyalan, S., Bigler, S., Barber, H. Transplantation (1996)
- Tirilazad mesylate increases dopaminergic neuronal survival in the in Oculo grafting model. Björklund, L., Spenger, C., Strömberg, I. Exp. Neurol. (1997)
- The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease in rats. Yue, G., Sun, F.F., Dunn, C., Yin, K., Wong, P.Y. J. Pharmacol. Exp. Ther. (1996)
- 21-Aminosteroid lipid peroxidation inhibitor U74006F protects against cerebral ischemia in gerbils. Hall, E.D., Pazara, K.E., Braughler, J.M. Stroke (1988)
- Antioxidant effects in brain and spinal cord injury. Hall, E.D., Braughler, J.M., McCall, J.M. J. Neurotrauma (1992)