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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hybridization, Genetic

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Disease relevance of Hybridization, Genetic


High impact information on Hybridization, Genetic

  • By crossbreeding with transgenic mice expressing human LPL driven by a muscle-specific promoter, mouse lines were generated that express LPL exclusively in muscle but not in any other tissue [5].
  • The clustering of all African zebu mtDNA sequences within the taurine lineage is attributed to ancestral crossbreeding with the earlier B. taurus inhabitants of the continent [6].
  • We did this by crossbreeding human IAPP transgenic mice with RIP-Tag mice that develop islet tumors and then culturing one of these islet tumors from two separate offspring of this cross [7].
  • These phenotypic defects were not observed in the opposite type of mating combination, despite the feto-placental overexpression of hRN and hANG detected in both types of crossbreeding [8].
  • Crossbreeding of Kv1DN mice with mice expressing a truncated Kv2.1 polypeptide (Kv2DN) eliminated I(K,slow2) [9].

Biological context of Hybridization, Genetic


Anatomical context of Hybridization, Genetic


Associations of Hybridization, Genetic with chemical compounds

  • Using genetic hybridization analysis we identified seven polymorphic genes for the fermentation of melibiose in different Mel+ strains of Saccharomyces cerevisiae [16].
  • The gonadal tumorigenesis was gonadotropin-dependent, since TG mice rendered gonadotropin-deficient by crossbreeding them into the hypogonadotropic hpg genetic background, or by treating them with a gonadotropin-releasing hormone (GnRH) antagonist, did not develop tumors [17].
  • Cholesterol and cholesterol oxidation products (COPs) were determined in four different groups of dry-cured Iberian hams, based on the feeding received by pigs and their degree of crossbreeding [18].
  • Crossbreeding is useful in producing new citrus fruits that have juices with the desirable characteristics of their parents without formation of dimethyl sulfide which is an off-flavor [19].
  • The FV-4R gene was probably acquired by the naturally occurring crossbreeding of LC feral mice with another species of feral mice (Mus castaneus) from Southeast Asia. The FV-4R gp70 does not block entry of the amphotropic MuLV that uses a separate cell surface receptor [20].

Gene context of Hybridization, Genetic

  • METHODS AND RESULTS: Mice with a combined heterozygous TFPI deficiency and homozygous apolipoprotein E deficiency (TFPI(+/-)/apoE(-/-)) were generated by crossbreeding, and they were analyzed for atherosclerosis throughout the vascular tree [21].
  • Next, we generated liver-specific MnSOD-deficient mice by crossbreeding with Alb-Cre transgenic mice [22].
  • Using genetic hybridization analysis, electrophoretic karyotyping and PCR-RFLP of the MET2 gene, we found that the yeast Saccharomyces bayanus var. uvarum is associated with certain types of wines produced in the Val de Loire, Sauternes, and Jurancon regions [23].
  • These data support the previous notion that the Hokkaido and Tohoku mice experienced genetic hybridization between primary residents of CAS origin and MUS newcomers arriving via a southern route [24].
  • Crossbreeding of the two TG mouse lines resulted in double TG mice (Inhalpha/TK-Inhalpha/Tag), which also developed gonadal tumors [25].

Analytical, diagnostic and therapeutic context of Hybridization, Genetic


  1. Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. Baltatu, O., Cayla, C., Iliescu, R., Andreev, D., Jordan, C., Bader, M. J. Am. Soc. Nephrol. (2002) [Pubmed]
  2. Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia). Kishnani, P.S., Faulkner, E., VanCamp, S., Jackson, M., Brown, T., Boney, A., Koeberl, D., Chen, Y.T. Vet. Pathol. (2001) [Pubmed]
  3. Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2. Hayek, T., Pavlotzky, E., Hamoud, S., Coleman, R., Keidar, S., Aviram, M., Kaplan, M. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  4. Protection from obesity in mice lacking the VLDL receptor. Goudriaan, J.R., Tacken, P.J., Dahlmans, V.E., Gijbels, M.J., van Dijk, K.W., Havekes, L.M., Jong, M.C. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  5. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. Weinstock, P.H., Bisgaier, C.L., Aalto-Setälä, K., Radner, H., Ramakrishnan, R., Levak-Frank, S., Essenburg, A.D., Zechner, R., Breslow, J.L. J. Clin. Invest. (1995) [Pubmed]
  6. Evidence for two independent domestications of cattle. Loftus, R.T., MacHugh, D.E., Bradley, D.G., Sharp, P.M., Cunningham, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid. Andrikopoulos, S., Verchere, C.B., Teague, J.C., Howell, W.M., Fujimoto, W.Y., Wight, T.N., Kahn, S.E. Diabetes (1999) [Pubmed]
  8. Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy. Takimoto-Ohnishi, E., Saito, T., Ishida, J., Ohnishi, J., Sugiyama, F., Yagami, K., Fukamizu, A. Mol. Endocrinol. (2005) [Pubmed]
  9. Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN mice. Zhou, J., Kodirov, S., Murata, M., Buckett, P.D., Nerbonne, J.M., Koren, G. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  10. Induction of parturition, progesterone secretion, and delivery of placenta in beef heifers given relaxin with cloprostenol or dexamethasone. Musah, A.I., Schwabe, C., Willham, R.L., Anderson, L.L. Biol. Reprod. (1987) [Pubmed]
  11. Hormonal regulation of human follicle-stimulating hormone-beta subunit gene expression: GnRH stimulation and GnRH-independent androgen inhibition. Kumar, T.R., Low, M.J. Neuroendocrinology (1995) [Pubmed]
  12. An experimental comparison of equivalent terminal and rotational crossbreeding systems in swine: sow and litter performance. Kuhlers, D.L., Jungst, S.B., Little, J.A. J. Anim. Sci. (1994) [Pubmed]
  13. K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. Kanezaki, Y., Obata, T., Matsushima, R., Minami, A., Yuasa, T., Kishi, K., Bando, Y., Uehara, H., Izumi, K., Mitani, T., Matsumoto, M., Takeshita, Y., Nakaya, Y., Matsumoto, T., Ebina, Y. Endocr. J. (2004) [Pubmed]
  14. Influence of mouse placental factors on in vitro antibody synthesis. Miranda, S., Borel, I.M., Freire, S.M., Binaghi, R., Margni, R. J. Reprod. Immunol. (1996) [Pubmed]
  15. Prenatal diagnosis of ornithine transcarbamylase deficiency: results in Spfash mice. Monastiri, K., Rabier, D., Kamoun, P. Prenat. Diagn. (1993) [Pubmed]
  16. A new family of polymorphic genes in Saccharomyces cerevisiae: alpha-galactosidase genes MEL1-MEL7. Naumov, G., Turakainen, H., Naumova, E., Aho, S., Korhola, M. Mol. Gen. Genet. (1990) [Pubmed]
  17. Transgenic mouse models for gonadal tumorigenesis. Rahman, N.A., Kananen Rilianawati, K., Paukku, T., Mikola, M., Markkula, M., Hämäläinen, T., Huhtaniemi, I.T. Mol. Cell. Endocrinol. (1998) [Pubmed]
  18. Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. Petrón, M.J., García-Regueiro, J.A., Martín, L., Muriel, E., Antequera, T. J. Agric. Food Chem. (2003) [Pubmed]
  19. S-methylmethionine sulfonium in fruits of citrus hybrids. Sakamoto, K., Inoue, A., Nakatani, M., Kozuka, H., Ohta, H., Osajima, Y. Biosci. Biotechnol. Biochem. (1996) [Pubmed]
  20. Genetic control of retroviral disease in aging wild mice. Gardner, M.B. Genetica (1993) [Pubmed]
  21. Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice. Westrick, R.J., Bodary, P.F., Xu, Z., Shen, Y.C., Broze, G.J., Eitzman, D.T. Circulation (2001) [Pubmed]
  22. Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Ikegami, T., Suzuki, Y., Shimizu, T., Isono, K., Koseki, H., Shirasawa, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  23. Association of Saccharomyces bayanus var. uvarum with some French wines: genetic analysis of yeast populations. Naumov, G.I., Masneuf, I., Naumova, E.S., Aigle, M., Dubourdieu, D. Res. Microbiol. (2000) [Pubmed]
  24. Phylogeographic origin of Hokkaido house mice (Mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance. Terashima, M., Furusawa, S., Hanzawa, N., Tsuchiya, K., Suyanto, A., Moriwaki, K., Yonekawa, H., Suzuki, H. Heredity (2006) [Pubmed]
  25. Gonadal tumors of mice double transgenic for inhibin-alpha promoter-driven simian virus 40 T-antigen and herpes simplex virus thymidine kinase are sensitive to ganciclovir treatment. Mikola, M.K., Rahman, N.A., Paukku, T.H., Ahtiainen, P.M., Vaskivuo, T.E., Tapanainen, J.S., Poutanen, M., Huhtaniemi, I.T. J. Endocrinol. (2001) [Pubmed]
  26. Artificial insemination and natural mating in the crossbreeding of the Muscovy drake and the Pekin duck. Gvaryahu, G., Robinzon, B., Meltzer, A., Perek, M., Snapir, N. Poult. Sci. (1984) [Pubmed]
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