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MeSH Review

Aborted Fetus

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Disease relevance of Aborted Fetus


High impact information on Aborted Fetus

  • We analyzed the levels of normal CFTR messenger RNA (mRNA) in different organs of an aborted fetus carrying the 3849 + 10 kb C--> T mutation, and found that they correlated with the histopathologic changes observed in these organs [6].
  • The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation [7].
  • Using a radioactive in situ hybridization method, we examined archival material from 17 Wilms tumors (including nine with nephrogenic rests), four therapeutically aborted embryos (37 to 56 days), three fetuses on whom autopsies had been performed, and one neonate for expression of hTR [8].
  • The reproductive performance of female cats is severely affected by dietary taurine deficiency resulting in excessive reproductive wastage, including frequently resorbed or aborted fetuses and stillborn or low birth-weight live kittens [9].
  • In addition, livers of one aborted fetus with OTC deficiency and four normal individuals were studied [10].

Biological context of Aborted Fetus


Anatomical context of Aborted Fetus


Associations of Aborted Fetus with chemical compounds


Gene context of Aborted Fetus

  • Formalin-fixed, paraffin-embedded multi-organ tissue blocks from aborted fetuses (age range 7-22 weeks) were immunostained for Ii/CD74 and MHC class II antigens using commercially available monoclonal antibodies for Ii/CD74 (LN2) and MHC class II antigens (LN3), respectively [23].
  • GDNF expression was examined immunocytochemically in developing human fetal brains obtained from aborted fetuses ranging from 7 to 39 weeks in gestational age [24].
  • Symmetry analysis of joint wife/husband and mother/infant distribution suggests that when ACP1 activity is lower in the mother than in either her aborted fetus or her child, the probability of abortion is higher and the survival to term is lower as compared to pairs in which the ACP1 activity is higher in the mother than in her fetus [25].
  • Radiological and histological studies confirmed the presence of diastrophic dysplasia in the aborted fetus [26].
  • EMCV-specific SN antibody titers up to 1:12,800 were detected in thoracic and ascitis fluids of aborted fetuses and in sera of convalescent pigs [27].

Analytical, diagnostic and therapeutic context of Aborted Fetus


  1. Alterations in lipid incorporation in Duchenne muscular dystrophy. Studies of fresh and cultured muscle. Ionasescu, V., Monaco, L., Sandra, A., Ionasescu, R., Burmeister, L., Deprosse, C., Stern, L.Z. J. Neurol. Sci. (1981) [Pubmed]
  2. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. Ober, C., Steck, T., van der Ven, K., Billstrand, C., Messer, L., Kwak, J., Beaman, K., Beer, A. J. Reprod. Immunol. (1993) [Pubmed]
  3. Expression of laminin subunits in human fetal skeletal muscle. Sewry, C.A., Chevallay, M., Tomé, F.M. Histochem. J. (1995) [Pubmed]
  4. Changes in thyroid, cerebral cortex and bones of therapeutically aborted fetuses from endemic goiter region supplied with iodized salt for 5 years. Liu, J.L., Zhuang, Z.J., Cao, X.M., Liu, S.A., Zhong, F.G., Gu, Z.G., Yang, P.S., Deng, C.J. Chin. Med. J. (1988) [Pubmed]
  5. Prenatal diagnosis of partial trisomy 22 derived from a maternal t(11; 22) (q23; q11). Sou, S., Takabayashi, T., Sasaki, H., Sasamoto, K., Shintaku, Y., Li, Z.J., Ozawa, N., Yajima, A. Tohoku J. Exp. Med. (1987) [Pubmed]
  6. Variable levels of normal RNA in different fetal organs carrying a cystic fibrosis transmembrane conductance regulator splicing mutation. Chiba-Falek, O., Parad, R.B., Kerem, E., Kerem, B. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  7. Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. Zetterberg, H., Regland, B., Palmér, M., Ricksten, A., Palmqvist, L., Rymo, L., Arvanitis, D.A., Spandidos, D.A., Blennow, K. Eur. J. Hum. Genet. (2002) [Pubmed]
  8. Expression of the RNA component of telomerase in Wilms tumor and nephrogenic rest recapitulates renal embryogenesis. Yashima, K., Maitra, A., Timmons, C.F., Rogers, B.B., Pinar, H., Shay, J.W., Gazdar, A.F. Hum. Pathol. (1998) [Pubmed]
  9. Dietary taurine and feline reproduction and development. Sturman, J.A. J. Nutr. (1991) [Pubmed]
  10. Carbamyl phosphate synthetase and ornithine transcarbamylase activities in enzyme-deficient human liver measured by radiochromatography and correlated with outcome. Tuchman, M., Tsai, M.Y., Holzknecht, R.A., Brusilow, S.W. Pediatr. Res. (1989) [Pubmed]
  11. Tissue distribution of the lipocalin alpha-1 microglobulin in the developing human fetus. Lögdberg, L.E., Akerström, B., Badve, S. J. Histochem. Cytochem. (2000) [Pubmed]
  12. Prenatal diagnosis of Fukuyama-type congenital muscular dystrophy by microsatellite analysis. Takai, Y., Tsutsumi, O., Harada, I., Fujii, T., Kashima, T., Kobayashi, K., Toda, T., Taketani, Y. Hum. Reprod. (1998) [Pubmed]
  13. Detection of numerical chromosome aberrations by comparative genomic hybridization. Daniely, M., Barkai, G., Goldman, B., Aviram-Goldring, A. Prenat. Diagn. (1999) [Pubmed]
  14. Population studies in northern Sweden. VIII. Ethnic heterogeneity and prenatal selection in the esterase D polymorphism. Beckman, G., Beckman, L. Hum. Hered. (1977) [Pubmed]
  15. Prenatal diagnosis of metachromatic leukodystrophy in a family with pseudo arylsulfatase A deficiency by the cerebroside sulfate loading test. Kihara, H., Ho, C.K., Fluharty, A.L., Tsay, K.K., Hartlage, P.L. Pediatr. Res. (1980) [Pubmed]
  16. Ethanol inhibits muscarinic receptor-mediated DNA synthesis and signal transduction in human fetal astrocytes. Guizzetti, M., Möller, T., Costa, L.G. Neurosci. Lett. (2003) [Pubmed]
  17. Distribution patterns of immunocompetent cells in the pregnant mouse uteri carrying allogeneic mouse and xenogeneic vole embryos. Widayati, D.T., Ohmori, Y., Fukuta, K. J. Anat. (2004) [Pubmed]
  18. Prenatal diagnosis of Gaucher disease. Assay of the beta-glucosidase activity in amniotic fluid cells cultivated in two laboratories with different cultivation conditions. Svennerholm, L., Håkansson, G., Lindsten, J., Wahlström, J., Dreborg, S. Clin. Genet. (1981) [Pubmed]
  19. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry. Clarke, D.J., Brundin, P., Strecker, R.E., Nilsson, O.G., Björklund, A., Lindvall, O. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1988) [Pubmed]
  20. Additive effect of RU 486 and anordrin on pregnancy interruption in the mouse. Forcelledo, M.L., Cardenas, H., Croxatto, H.B. Contraception. (1993) [Pubmed]
  21. Facts and artefacts in mevalonic aciduria: development of a stable isotope dilution GCMS assay for mevalonic acid and its application to physiological fluids, tissue samples, prenatal diagnosis and carrier detection. Hoffmann, G.F., Sweetman, L., Bremer, H.J., Hunneman, D.H., Hyánek, J., Kozich, V., Lehnert, W., Nyhan, W.L., Speidel, I., Trefz, F.K. Clin. Chim. Acta (1991) [Pubmed]
  22. Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy. Kashiwagi, M., Chaoui, R., Stallmach, T., Hürlimann, S., Lauper, U., Hebisch, G. Birth defects research. Part A, Clinical and molecular teratology. (2003) [Pubmed]
  23. Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus. Badve, S., Deshpande, C., Hua, Z., Lögdberg, L. J. Histochem. Cytochem. (2002) [Pubmed]
  24. Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain. Koo, H., Choi, B.H. Int. J. Dev. Neurosci. (2001) [Pubmed]
  25. The genetics of signal transduction and the feto-maternal relationship. A study of cytosolic low molecular weight phosphotyrosine phosphatase. Bottini, E., Cosmi, E., Nicotra, M., Santeusanio, G., La Torre, M., Bottini, N., Lucarini, N. Dis. Markers (1998) [Pubmed]
  26. Prenatal ultrasound diagnosis of diastrophic dysplasia at 16 weeks. Gollop, T.R., Eigier, A. Am. J. Med. Genet. (1987) [Pubmed]
  27. Outbreaks in Quebec pig farms of respiratory and reproductive problems associated with encephalomyocarditis virus. Dea, S., Bilodeau, R., Sauvageau, R., Martineau, G.P. J. Vet. Diagn. Invest. (1991) [Pubmed]
  28. Prenatal diagnosis of congenital methemoglobinemia with mental retardation. Kaftory, A., Freundlich, E., Manaster, J., Shukri, A., Hegesh, E. Isr. J. Med. Sci. (1986) [Pubmed]
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