Disease relevance of Aborted Fetus

• The incorporation of [3H] glycerol into lipids of fresh and cultured skeletal muscle obtained from patients with Duchenne muscular dystrophy (DMD), patients with myotonic dystrophy (My Dyst), controls, and aborted fetuses (10-12 weeks old) was studied [1].
• MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion [2].
• Merosin is therefore detected early during human fetal muscle development, and this should be taken into account when assessing aborted fetuses at risk for congenital muscular dystrophy [3].
• Changes in thyroid, cerebral cortex and bones of therapeutically aborted fetuses from endemic goiter region supplied with iodized salt for 5 years [4].
• The aborted fetus had multiple congenital anomalies consisting of microcephaly, cleft lip and palate [5].

High impact information on Aborted Fetus

• We analyzed the levels of normal CFTR messenger RNA (mRNA) in different organs of an aborted fetus carrying the 3849 + 10 kb C--> T mutation, and found that they correlated with the histopathologic changes observed in these organs [6].
• The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation [7].
• Using a radioactive in situ hybridization method, we examined archival material from 17 Wilms tumors (including nine with nephrogenic rests), four therapeutically aborted embryos (37 to 56 days), three fetuses on whom autopsies had been performed, and one neonate for expression of hTR [8].
• The reproductive performance of female cats is severely affected by dietary taurine deficiency resulting in excessive reproductive wastage, including frequently resorbed or aborted fetuses and stillborn or low birth-weight live kittens [9].
• In addition, livers of one aborted fetus with OTC deficiency and four normal individuals were studied [10].

Biological context of Aborted Fetus

• Formalin-fixed, paraffin-embedded multi-organ block tissue from aborted fetuses (gestational age range 7-22 weeks) was immunohistochemically examined for alpha(1)m reactivity [11].
• Brain malformations characteristic of FCMD in one of the aborted fetuses confirmed the diagnosis of FCMD at 19 weeks of gestation [12].
• In the present study, we applied the CGH technique in the detection of numerical chromosome abnormalities in 50 placentae of spontaneously aborted fetuses [13].
• The distribution of ES D phenotypes was very similar in spontaneously aborted fetuses, newborns and adults, hence there was no evidence for prenatal selection operating in this polymorphism [14].

Anatomical context of Aborted Fetus

• Fibroblasts derived from the aborted fetus showed a deficiency of arylsulfatase A and a similar inability to hydrolyze cerebroside sulfate in the loading test [15].
• Astrocyte cultures, deriving from legally aborted fetuses, were stained for GFAP and shown to be 90-95% pure [16].
• These results suggest: (1) the response of macrophages to dead embryos is completely inhibited, (2) uNK cells and mast cells increase near dead and aborted embryos, and (3) the increment in uNK cells responding to xenogeneic embryos is suppressed in scid mice, and the suppression may contribute partly to survival of the embryos [17].

Associations of Aborted Fetus with chemical compounds

• The glucosylceramide content of the liver from two aborted fetuses was not augmented [18].
• Human fetal mesencephalic dopamine (DA) neurons, obtained from 6.5-9 week old aborted fetuses, were grafted to the striatum of immunosuppressed rats with 6-hydroxydopamine lesions of the ascending mesostriatal DA pathway [19].
• Direct observation of aborted fetuses indicated that the resorptive process occurred earlier with RU 486 than with anordrin [20].
• Mevalonic acid concentration was much increased in tissues of the affected and aborted fetus [21].
• CONCLUSIONS: This constellation in a fetus aborted at 18 weeks extends the spectrum of complications possibly associated with cocaine abuse in pregnancy [22].

Gene context of Aborted Fetus

• Formalin-fixed, paraffin-embedded multi-organ tissue blocks from aborted fetuses (age range 7-22 weeks) were immunostained for Ii/CD74 and MHC class II antigens using commercially available monoclonal antibodies for Ii/CD74 (LN2) and MHC class II antigens (LN3), respectively [23].
• GDNF expression was examined immunocytochemically in developing human fetal brains obtained from aborted fetuses ranging from 7 to 39 weeks in gestational age [24].
• Symmetry analysis of joint wife/husband and mother/infant distribution suggests that when ACP1 activity is lower in the mother than in either her aborted fetus or her child, the probability of abortion is higher and the survival to term is lower as compared to pairs in which the ACP1 activity is higher in the mother than in her fetus [25].
• Radiological and histological studies confirmed the presence of diastrophic dysplasia in the aborted fetus [26].
• EMCV-specific SN antibody titers up to 1:12,800 were detected in thoracic and ascitis fluids of aborted fetuses and in sera of convalescent pigs [27].

Analytical, diagnostic and therapeutic context of Aborted Fetus

• The absence of cytochrome b5 reductase activity in the blood from the aborted fetus confirmed the prenatal diagnosis [28].

References