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Gene Review

CD74  -  CD74 molecule, major histocompatibility...

Homo sapiens

Synonyms: DHLAG, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLADG, II, ...
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Disease relevance of CD74


High impact information on CD74


Chemical compound and disease context of CD74


Biological context of CD74


Anatomical context of CD74

  • We have previously shown that H. pylori binds to CD74 on gastric epithelial cells [12].
  • Further confirmation of the interaction of urease B with CD74 was obtained using a fibroblast cell line transfected with CD74 that also responded with NF-kappaB activation and IL-8 production [12].
  • Macrophages with positive staining for the antimicrobial peptides also stained positively for CD68 and CD74 [13].
  • CD74 expression was increased dramatically on gastric biopsies from H. pylori-positive patients and gastric cell lines exposed to the bacteria [14].
  • Schwann cells in biopsies from patients and normal controls expressed high levels of the invariant chain, CD74, a molecule involved in the intracellular sorting of MHC class II molecules [15].

Associations of CD74 with chemical compounds

  • Formalin-fixed, paraffin-embedded multi-organ tissue blocks from aborted fetuses (age range 7-22 weeks) were immunostained for Ii/CD74 and MHC class II antigens using commercially available monoclonal antibodies for Ii/CD74 (LN2) and MHC class II antigens (LN3), respectively [16].
  • MIF binding was associated with the serine phosphorylation of CD74 and CD44 [6].
  • EXPERIMENTAL DESIGN: Doxorubicin (dox) conjugates of the murine and humanized versions of the anti B-cell antibody LL1, targeting CD74, were prepared, along with a nonspecific control dox-antibody conjugate, targeting carcinoembryonic antigen [17].
  • The subcellular distribution patterns of molecules involved in the process of antigen loading [HLA-DR, HLA-DM, and the cytoplasmic and luminal parts of the invariant chain (Ii, CD74)] were investigated in Langerhans cells (LC), both qualitatively and quantitatively [18].
  • Methods for correction of chromatic aberration and identification of submicroscopic artefacts are presented, with data for the lipopolysaccharide/CD14 and MHC class II/CD74 systems [19].

Physical interactions of CD74

  • MIF appears to interact with cell surface CD74, with consequent activation of MAP kinases but possibly not NFkappaB intracellular signal transduction [20].

Other interactions of CD74

  • Increased CD74 expression by cells increased IL-8 production in response to H. pylori, and agents that block CD74 decreased these responses [1].
  • These cells were CD20+, CD3-, CD45RO-, KP-1-, PGM1-, with occasional positive reaction for MB-1 and CD74, indicating their B-cell nature, i.e., MBL [21].
  • Our evidence suggests MIF interacts with the invariant chain, CD74 and the major cell surface receptor for HA, CD44 [22].
  • Neoplastic lymphoid cells were positive for CD20, CD45, CD74 and CDw75 [23].
  • A panel of monoclonal antibodies (Leucocyte Common Antigen [CD45], LN-1 [CDw75], LN-2 [CD74], LN-3, L-26, UCHL-1 [CD45RO] and MT-1) which identify B and T cell surface markers were applied to benign lymphocytoma cutis and malignant lymphoma of the skin in paraffin-embedded sections [24].

Analytical, diagnostic and therapeutic context of CD74


  1. Helicobacter pylori binds to CD74 on gastric epithelial cells and stimulates interleukin-8 production. Beswick, E.J., Bland, D.A., Suarez, G., Barrera, C.A., Fan, X., Reyes, V.E. Infect. Immun. (2005) [Pubmed]
  2. Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells. Meyer-Siegler, K.L., Iczkowski, K.A., Leng, L., Bucala, R., Vera, P.L. J. Immunol. (2006) [Pubmed]
  3. CD74 is expressed by multiple myeloma and is a promising target for therapy. Burton, J.D., Ely, S., Reddy, P.K., Stein, R., Gold, D.V., Cardillo, T.M., Goldenberg, D.M. Clin. Cancer Res. (2004) [Pubmed]
  4. Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas. Hansen, H.J., Ong, G.L., Diril, H., Valdez, A., Roche, P.A., Griffiths, G.L., Goldenberg, D.M., Mattes, M.J. Biochem. J. (1996) [Pubmed]
  5. LN-2 (CD74). A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Lazova, R., Moynes, R., May, D., Scott, G. Cancer (1997) [Pubmed]
  6. CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex. Shi, X., Leng, L., Wang, T., Wang, W., Du, X., Li, J., McDonald, C., Chen, Z., Murphy, J.W., Lolis, E., Noble, P., Knudson, W., Bucala, R. Immunity (2006) [Pubmed]
  7. MIF signal transduction initiated by binding to CD74. Leng, L., Metz, C.N., Fang, Y., Xu, J., Donnelly, S., Baugh, J., Delohery, T., Chen, Y., Mitchell, R.A., Bucala, R. J. Exp. Med. (2003) [Pubmed]
  8. Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. Strubin, M., Berte, C., Mach, B. EMBO J. (1986) [Pubmed]
  9. Alteration in the gene expression pattern of primary monocytes after adhesion to endothelial cells. Thomas-Ecker, S., Lindecke, A., Hatzmann, W., Kaltschmidt, C., Zänker, K.S., Dittmar, T. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  10. Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival. Starlets, D., Gore, Y., Binsky, I., Haran, M., Harpaz, N., Shvidel, L., Becker-Herman, S., Berrebi, A., Shachar, I. Blood (2006) [Pubmed]
  11. Characterization of the fetal inflammatory response to cytomegalovirus placentitis. An immunohistochemical study. Schwartz, D.A., Khan, R., Stoll, B. Arch. Pathol. Lab. Med. (1992) [Pubmed]
  12. The Helicobacter pylori urease B subunit binds to CD74 on gastric epithelial cells and induces NF-kappaB activation and interleukin-8 production. Beswick, E.J., Pinchuk, I.V., Minch, K., Suarez, G., Sierra, J.C., Yamaoka, Y., Reyes, V.E. Infect. Immun. (2006) [Pubmed]
  13. Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastroinstestinal tracts. Wah, J., Wellek, A., Frankenberger, M., Unterberger, P., Welsch, U., Bals, R. Cell Tissue Res. (2006) [Pubmed]
  14. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. Beswick, E.J., Das, S., Pinchuk, I.V., Adegboyega, P., Suarez, G., Yamaoka, Y., Reyes, V.E. J. Immunol. (2005) [Pubmed]
  15. Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy. Van Rhijn, I., Van den Berg, L.H., Bosboom, W.M., Otten, H.G., Logtenberg, T. Brain (2000) [Pubmed]
  16. Expression of invariant chain (CD 74) and major histocompatibility complex (MHC) class II antigens in the human fetus. Badve, S., Deshpande, C., Hua, Z., Lögdberg, L. J. Histochem. Cytochem. (2002) [Pubmed]
  17. Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate. Griffiths, G.L., Mattes, M.J., Stein, R., Govindan, S.V., Horak, I.D., Hansen, H.J., Goldenberg, D.M. Clin. Cancer Res. (2003) [Pubmed]
  18. HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cells. Andersson, T., Patwardhan, A., Emilson, A., Carlsson, K., Scheynius, A. Arch. Dermatol. Res. (1998) [Pubmed]
  19. Co-localization of cell surface receptors at high spatial resolution by single-particle fluorescence imaging. Karakikes, I., Barber, R.E., Morrison, I.E., Fernández, N., Cherry, R.J. Biochem. Soc. Trans. (2003) [Pubmed]
  20. Macrophage migration inhibitory factor in rheumatoid arthritis. Morand, E.F., Leech, M. Front. Biosci. (2005) [Pubmed]
  21. Occurrence of monocytoid B-lymphocytes in Hodgkin's disease. Ohsawa, M., Kanno, H., Naka, N., Aozasa, K. Mod. Pathol. (1994) [Pubmed]
  22. Inhibition of macrophage migration inhibitory factor decreases proliferation and cytokine expression in bladder cancer cells. Meyer-Siegler, K.L., Leifheit, E.C., Vera, P.L. BMC Cancer (2004) [Pubmed]
  23. Histiocyte-rich B-cell lymphoma. Sun, T., Susin, M., Tomao, F.A., Brody, J., Koduru, P., Hajdu, S.I. Hum. Pathol. (1997) [Pubmed]
  24. Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections. Toyota, N., Matsuo, S., Iizuka, H. J. Dermatol. (1991) [Pubmed]
  25. Biochemical analysis of plasma-soluble invariant chains and their complex formation with soluble HLA-DR. Rebmann, V., Dornmair, K., Grosse-Wilde, H. Tissue Antigens (1997) [Pubmed]
  26. Constitutive intracellular expression of human leukocyte antigen (HLA)-DO and HLA-DR but not HLA-DM in trophoblast cells. Ranella, A., Vassiliadis, S., Mastora, C., Valentina, M., Dionyssopoulou, E., Athanassakis, I. Hum. Immunol. (2005) [Pubmed]
  27. Localization of an antibody to CD74 (MHC class II invariant chain) to human B cell lymphoma xenografts in nude mice. Shih, L., Ong, G.L., Burton, J., Mishina, D., Goldenberg, D.M., Mattes, M.J. Cancer Immunol. Immunother. (2000) [Pubmed]
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