Disease relevance of Platelet Adhesiveness

• Finally, possible reasons to explain the increased incidence of CHD associated with proteinuria in IDDM patients, including lipoprotein abnormalities, increased fibrinogen levels, increased platelet adhesiveness, and altered hemostatic variables, are discussed [1].
• Nicotine also increases platelet adhesiveness, raising the risk of thrombotic microvascular occlusion and tissue ischemia [2].
• We assume that the antithrombotic effect of the PC activator from the A. blomhoffi venom in the platelet-dependent thrombosis model is caused by PC activation and subsequent factor V inactivation as well as by platelet adhesiveness reduction [3].
• Plasma beta-thromboglobulin is correlated with platelet adhesiveness to bovine endothelium in patients with diabetes mellitus [4].
• It was undertaken with the aim of investigating obesity indices (i.e. body mass index, skin fold thickness, waist hip ratio and % fat in the body); lipid profile (including serum total cholesterol, triglyceride, VLDL, LDL and HDL-cholesterol) levels and platelet adhesiveness in both the groups [5].

High impact information on Platelet Adhesiveness

• Platelet adhesiveness was tested ex vivo in a group of six normal individuals receiving varying doses of alpha-tocopherol [6].
• (3) Strenuous exercise is associated with higher percentages of ADP- and clonidine plus ADP-enhanced platelet adhesiveness and [Ca2+]i than at rest [7].
• There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only [8].
• The mechanism of action that provides symptom relief with pentoxifylline is poorly understood but is thought to involve red blood cell deformability as well as a reduction in fibrinogen concentration, platelet adhesiveness and whole blood viscosity [9].
• Platelet adhesiveness, c-AMP level in platelets and the conversion of arachidonic acid to thromboxane A2 were not influenced by MCI-9042 [10].

Chemical compound and disease context of Platelet Adhesiveness

• Effect of angiotensin II upon platelet adhesiveness and the thrombelastogram in patients with essential arterial hypertension [11].
• After a glucose load with fibre the platelet adhesiveness in patients with diabetes mellitus fell significantly (p = less than 0.001) [12].
• In hypothyroidism platelet adhesiveness was abnormally low but increased to normal value after thyroid hormone replacement [13].
• Decreased platelet count and platelet adhesiveness as well as increased values of the protamine sulfate test were found in 26 patients with septic abortion (9 of them anuric) [14].

Biological context of Platelet Adhesiveness

• This case demonstrated a myeloma-associated monoclonal antibody that interacted specifically with that part of the Factor VIII molecule necessary for Factor VIII ristocetin cofactor activity, normal platelet adhesiveness, and bleeding time [15].
• Six of seven showed hyperaggregation with epinephrine and/or collagen, three showed increased platelet adhesiveness, three showed increased platelet count, and one showed increased microemboli [16].
• Under these experimental conditions, oral dose of S-8527 (30-300 mg/kg) for 14 days decreased platelet adhesiveness and ADP-induced platelet aggregation, but did not decrease collagen-induced platelet aggregation [17].
• These results support the view that ethamsylate acts on the first step of hemostasis, by improving platelet adhesiveness and restoring capillary resistance [18].
• The hypotensive effect of Guancydine is associated with a decrease of platelet adhesiveness and an activation of fibrinolysis [19].

Anatomical context of Platelet Adhesiveness

• The effect of vitamin C on blood lipids, fibrinolytic activity and platelet adhesiveness in patients with coronary artery disease [20].
• Compared to normal subjects without arteriosclerotic complications, diabetic patients had higher plasma BTG (34.8 +/- 1.8 (SEM) vs. 21.3 +/- 1.8 ng/ml) and platelet adhesiveness to endothelium (PAE) (3240 +/- 170 vs. 2430 +/- 120 X 10(3) platelets per well) (p less than 0.0002, respectively) [4].
• These studies demonstrate that platelets in some diabetic patients are excessively adhesive to vascular endothelium, and that plasma BTG and platelet adhesiveness are intercorrelated [4].

Associations of Platelet Adhesiveness with chemical compounds

• On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid [21].
• Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid [21].
• Inhibition of human and animal platelet adhesiveness to glass bead columns by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid [21].
• Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column [21].
• Platelet adhesiveness was not affected by lisofylline [22].

Gene context of Platelet Adhesiveness

• Normal platelet adhesiveness and aggregation in congenital PTA or Hageman factor deficiency [23].
• There were no significant alterations in platelet adhesiveness, plasminogen activator, plasminogen, FR-antigen and haematocrit [24].
• Is the pro-adhesive activity of plasma von Willebrand factor counteracted by a physiological inhibitor of platelet adhesiveness [25]?
• In our experiments, fibronectin purified from human plasma modified platelet adhesiveness, though not dramatically [26].
• The 807 C/T dimorphism in the GPIa gene has been shown to affect GPIaIIa receptor density, which can affect platelet adhesiveness to collagens [27].

Analytical, diagnostic and therapeutic context of Platelet Adhesiveness

• Gliclazide is an oral hypoglycaemic agent which has been shown in animal models to reduce platelet adhesiveness [28].
• Long-term oral administration of caprylate (2 and 3 weeks) to rabbits resulted in a progressive and significant decrease in platelet adhesiveness in these animals compared to that in a control group receiving saline [29].

References