Disease relevance of Arthritis, Gouty

• Hyperuricemia is common, acute gouty arthritis is less common than uric acid levels would predict, and overt tophaceous deposits of uric acid are exceptional [1].
• Roles for factor XII, prekallikrein and kininogen have been suggested in gouty arthritis, allergic disorders and cystic fibrosis but the evidence is not yet convincing in these disorders [2].
• CONCLUSIONS: Gouty arthritis is uncommon in SLE; it occurs primarily in patients with long-standing SLE and nephritis [3].
• BACKGROUND: In gouty arthritis, monosodium urate (MSU) crystals interact with monocytes and neutrophils to produce inflammatory reactions associated with acute synovitis [4].
• Colchicine is used for the treatment of various diseases including gouty arthritis, familial Mediterranean fever (FMF) and Behcet's disease [5].

High impact information on Arthritis, Gouty

• Studies in vitro established these "beachball" structures as chemically identical to classic "needles" of monosodium urate monohydrate, the prime factor in gouty arthritis [6].
• Ibuprofen in the treatment of acute gouty arthritis [7].
• The inflammatory response to intraarticular urate crystals is known to be variable in gouty arthritis [8].
• The family with ADMCKD2 fulfills the typical diagnostic criteria of ADMCKD, complicated by hyperuricemia and gouty arthritis [9].
• This study was undertaken to evaluate the biologic role of PPAR gamma in self-limiting episodes of acute gouty arthritis [10].

Chemical compound and disease context of Arthritis, Gouty

• The excessive purine synthesis that underlies the hyperuricemia of a substantial number of patients with gouty arthritis reflects alterations in the normal mechanism regulating the rate of purine nucleotide synthesis [11].
• Indoprofen for acute gouty arthritis [12].
• Effect of fenoprofen calcium on acute gouty arthritis [13].
• Double-blind study of fenoprofen versus phenylbutazone in acute gouty arthritis [14].
• Human phosphoribosylpyrophosphate synthetase has been purified 4500-fold to electrophoretic homogeneity from the erythrocytes of normal individuals and of two brothers in whom excessive activity of this enzyme results in excessive rated of purine nucleotide and uric acid synthesis de novo and gouty arthritis [15].

Biological context of Arthritis, Gouty

• RESULTS: Of the gouty diathesis patients gouty arthritis was present in 21% of those with uric acid and 12% of those with calcium stones [16].
• After adjustment for age, sex, lipid profile, and blood pressure, hyperuricemia was found to be significantly associated with serum creatinine (OR 2.40, 95% CI 1.91-3.04), BMI (OR 1.24, 95% CI 1.11-1.40), and a family history of gouty arthritis in parents (OR 2.01, 95% CI 1.02-3.96) [17].
• Prospective study of morphology and phagocytosis of synovial fluid monosodium urate crystals in gouty arthritis [18].
• METHODS: A case of hyperuricaemia and gouty arthritis in a young man with occupational exposure to molybdenum is described [19].
• HPRT gene point mutations in three gouty arthritis and one Lesch-Nyhan patient have been identified by peptide sequencing [20].

Anatomical context of Arthritis, Gouty

• Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis [21].
• CONCLUSIONS: The analysis of MMP-9 in SF samples can reveal the inflammatory condition of the knee joints with gouty arthritis [22].

Gene context of Arthritis, Gouty

• Urokinase-type plasminogen activator, receptor, and inhibitor correlating with gelatinase-B (MMP-9) contribute to inflammation in gouty arthritis of the knee [23].
• Increased uPA, suPAR, and PAI-1 antigenic values in gouty arthritis SF were also correlated to each other (p < 0.001, p < 0.001, p < 0.001) [23].
• RESULTS: Gelatin zymography revealed that not only activated MMP-2 levels but also proMMP-9 levels in SF from the knee joints of gouty arthritis were associated with the local arthritis activity scores (LAS) (p < 0.001) and correlated well with the neutrophil counts in SF as well (p < 0.001) [22].
• Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18 [24].
• The plasma concentrations of IL-18, IL-6, and IL-8 were elevated in the presence of gouty arthritis in the gout patients [24].

Analytical, diagnostic and therapeutic context of Arthritis, Gouty

• In rheumatoid arthritis and gouty arthritis, specific immunoassay identified substantial quantities of the initial C3 cleavage fragments [25].
• METHODS: Patients with gouty arthritis taking a stable dose of probenecid for at least 3 months were enrolled in a prospective crossover study [26].
• The concentrations of PGD2, PGE2, PGF2 alpha, 6-keto-PGF1 alpha and TXB2 in synovial fluid from patients with rheumatoid arthritis (RA), Reiter's disease (RD), acute gouty arthritis (GA) and osteoarthritis (OA) were measured by radioimmunoassay [27].

References