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MeSH Review

Fractures, Spontaneous

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Disease relevance of Fractures, Spontaneous


Psychiatry related information on Fractures, Spontaneous


High impact information on Fractures, Spontaneous


Chemical compound and disease context of Fractures, Spontaneous

  • Using a mouse mutant that fractures spontaneously and dies at a very young age, we identified that a deletion of the GULO gene, which is involved in the synthesis of vitamin C, is the cause of impaired osteoblast differentiation, reduced bone formation, and development of spontaneous fractures [11].
  • We report 11 fluoride-treated postmenopausal patients who developed spontaneous fractures of the femoral necks, all subcapital initially [12].
  • The administration of pharmacological doses of vitamin A to growing male rats resulted in weakness and spontaneous fractures [13].
  • Recent studies have shown that clodronate is effective in the treatment of malignancy hypercalcaemia, relief of bone pain and decreases the risk of pathological fracture [14].
  • However, in our previous study, 1 year treatment with high-dose etidronate (EHDP) did not increase microdamage accumulation in most skeletal sites of dogs in spite of complete remodeling suppression and the occurrence of spontaneous fractures of ribs and/or thoracic spinous processes [15].

Biological context of Fractures, Spontaneous


Anatomical context of Fractures, Spontaneous


Gene context of Fractures, Spontaneous


Analytical, diagnostic and therapeutic context of Fractures, Spontaneous


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  2. Burkitt's lymphoma developing in a 7-year-old boy with hyper-IgE syndrome. Gorin, L.J., Jeha, S.C., Sullivan, M.P., Rosenblatt, H.M., Shearer, W.T. J. Allergy Clin. Immunol. (1989) [Pubmed]
  3. Subclinical hypervitaminosis A causes fragile bones in rats. Johansson, S., Lind, P.M., Hakansson, H., Oxlund, H., Orberg, J., Melhus, H. Bone (2002) [Pubmed]
  4. Hyperprolactinemia and bone mineral density: the potential impact of antipsychotic agents. Naidoo, U., Goff, D.C., Klibanski, A. Psychoneuroendocrinology (2003) [Pubmed]
  5. Haemarthrosis due to fracture through amyloid deposits in bone in Portuguese familial amyloidosis. Allard, S.A., King, R.H., Thomas, P.K., Bourke, B.E. Ann. Rheum. Dis. (1991) [Pubmed]
  6. Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa. Kahl, K.G., Rudolf, S., Dibbelt, L., Stoeckelhuber, B.M., Gehl, H.B., Hohagen, F., Schweiger, U. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  7. Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral. Pereira, R., Khillan, J.S., Helminen, H.J., Hume, E.L., Prockop, D.J. J. Clin. Invest. (1993) [Pubmed]
  8. Spontaneous fracture of polyvinyl chloride T tube. Gillison, W. Lancet (1977) [Pubmed]
  9. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Melhus, H., Michaëlsson, K., Kindmark, A., Bergström, R., Holmberg, L., Mallmin, H., Wolk, A., Ljunghall, S. Ann. Intern. Med. (1998) [Pubmed]
  10. Pamidronate in prevention of bone complications in metastatic breast cancer: a cost-effectiveness analysis. Hillner, B.E., Weeks, J.C., Desch, C.E., Smith, T.J. J. Clin. Oncol. (2000) [Pubmed]
  11. Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency. Mohan, S., Kapoor, A., Singgih, A., Zhang, Z., Taylor, T., Yu, H., Chadwick, R.B., Chung, Y.S., Chung, Y.S., Donahue, L.R., Rosen, C., Crawford, G.C., Wergedal, J., Baylink, D.J. J. Bone Miner. Res. (2005) [Pubmed]
  12. Spontaneous hip fractures in fluoride-treated patients: potential causative factors. Gutteridge, D.H., Price, R.I., Kent, G.N., Prince, R.L., Michell, P.A. J. Bone Miner. Res. (1990) [Pubmed]
  13. Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. Hough, S., Avioli, L.V., Muir, H., Gelderblom, D., Jenkins, G., Kurasi, H., Slatopolsky, E., Bergfeld, M.A., Teitelbaum, S.L. Endocrinology (1988) [Pubmed]
  14. Clodronate: the potential for the future. Powles, T. Bone (1991) [Pubmed]
  15. Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Mashiba, T., Turner, C.H., Hirano, T., Forwood, M.R., Jacob, D.S., Johnston, C.C., Burr, D.B. Bone (2001) [Pubmed]
  16. A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14. Jiao, Y., Li, X., Beamer, W.G., Yan, J., Tong, Y., Goldowitz, D., Roe, B., Gu, W. Mamm. Genome (2005) [Pubmed]
  17. The use of clodronate in multiple myeloma. Delmas, P.D. Bone (1991) [Pubmed]
  18. Anterior cord decompression and spinal stabilization for patients with metastatic lesions of the spine. Harrington, K.D. J. Neurosurg. (1984) [Pubmed]
  19. Bilateral spontaneous fractures of the acromion associated with amyloid arthropathy. Yamamoto, T., Tanaka, K., Kurosaka, M., Mizuno, K. J. Rheumatol. (2001) [Pubmed]
  20. Treatment of aneurysmal bone cysts of the pelvis and sacrum. Papagelopoulos, P.J., Choudhury, S.N., Frassica, F.J., Bond, J.R., Unni, K.K., Sim, F.H. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  21. Osteoporosis in rheumatoid arthritis. Dequeker, J., Maenaut, K., Verwilghen, J., Westhovens, R. Clinical and experimental rheumatology. (1995) [Pubmed]
  22. Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone. Dai, X.M., Zong, X.H., Akhter, M.P., Stanley, E.R. J. Bone Miner. Res. (2004) [Pubmed]
  23. Modulation of renal osteodystrophy by extrarenal production of calcitriol. Delmez, J.A., Dusso, A.S., Slatopolsky, E., Teitelbaum, S.L. American journal of nephrology. (1995) [Pubmed]
  24. Elevation of IL-6 in ATL patient with a pathological fracture. Anzai, S., Takayasu, S., Fujiwara, S., Tateyama, M., Taira, H., Takashita, M. J. Dermatol. (2002) [Pubmed]
  25. Pathologic hip fractures secondary to amyloidoma. Case report and review of the literature. Lai, K.N., Chan, K.W., Siu, D.L., Wong, C.C., Yeung, D. Am. J. Med. (1984) [Pubmed]
  26. Hemodialysis-associated amyloidosis and beta-2 microglobulin. Clinical and immunohistochemical study. Bardin, T., Zingraff, J., Shirahama, T., Noel, L.H., Droz, D., Voisin, M.C., Drueke, T., Dryll, A., Skinner, M., Cohen, A.S. Am. J. Med. (1987) [Pubmed]
  27. Monitoring hospital trauma mortality using statistical process control methods. Clark, D.E., Cushing, B.M., Bredenberg, C.E. J. Am. Coll. Surg. (1998) [Pubmed]
  28. Multiple myeloma: effect of daily dichloromethylene bisphosphonate on skeletal complications. Clemens, M.R., Fessele, K., Heim, M.E. Ann. Hematol. (1993) [Pubmed]
  29. Intralesional curettage for grades II and III giant cell tumors of bone. Lackman, R.D., Hosalkar, H.S., Ogilvie, C.M., Torbert, J.T., Fox, E.J. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  30. Unusual IgM-secreting multiple myeloma in a dog. Lautzenhiser, S.J., Walker, M.C., Goring, R.L. J. Am. Vet. Med. Assoc. (2003) [Pubmed]
  31. Pathologic fractures associated with idiopathic amyloidosis of bone in chronic hemodialysis patients. DiRaimondo, C.R., Casey, T.T., DiRaimondo, C.V., Stone, W.J. Nephron (1986) [Pubmed]
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