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MeSH Review


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Disease relevance of Paracoccidioides


High impact information on Paracoccidioides


Chemical compound and disease context of Paracoccidioides


Biological context of Paracoccidioides


Anatomical context of Paracoccidioides


Associations of Paracoccidioides with chemical compounds


Gene context of Paracoccidioides

  • Forty-eight hours after infection, equivalent numbers of viable Paracoccidioides brasiliensis yeast cells were recovered from the lungs of IL-4(-/-) and WT mice intratracheally infected with one million fungal cells [26].
  • Cloning and characterization of a LON gene homologue from the human pathogen Paracoccidioides brasiliensis [27].
  • Patients with active infection with Paracoccidioides brasiliensis present a Th2 immune response characterized by high Interleukin-4 and Interleukin-5 production [28].
  • In our previous study, it was observed that human peripheral blood polymorphonuclear leucocytes (PMNs) exhibited a fungistatic effect on yeast cells of Paracoccidioides brasiliensis, and that interferon-gamma (IFN-gamma), but not tumor necrosis factor-alpha or interleukin-8 (IL-8), enhanced the antifungal activity of PMNs [29].
  • The PbMDJ1 gene belongs to a conserved MDJ1/LON locus in thermodimorphic pathogenic fungi and encodes a heat shock protein that localizes to both the mitochondria and cell wall of Paracoccidioides brasiliensis [30].

Analytical, diagnostic and therapeutic context of Paracoccidioides


  1. 43-kilodalton glycoprotein from Paracoccidioides brasiliensis: immunochemical reactions with sera from patients with paracoccidioidomycosis, histoplasmosis, or Jorge Lobo's disease. Puccia, R., Travassos, L.R. J. Clin. Microbiol. (1991) [Pubmed]
  2. Antibody response to the 43 kDa glycoprotein of Paracoccidioides brasiliensis as a marker for the evaluation of patients under treatment. Giannini, M.J., Bueno, J.P., Shikanai-Yasuda, M.A., Stolf, A.M., Masuda, A., Amato Neto, V., Ferreira, A.W. Am. J. Trop. Med. Hyg. (1990) [Pubmed]
  3. Optimization of a mouse immunization protocol with Paracoccidioides brasiliensis antigens. Almeida, A.V., Fogaça, J., Chamma, L.G., Fecchio, D., Franco, M. Mem. Inst. Oswaldo Cruz (1995) [Pubmed]
  4. Connective matrix organization in chronic granulomas of experimental paracoccidioidomycosis. Kerr, I.B., de Oliveira, P.C., Lenzi, H.L. Mycopathologia (1988) [Pubmed]
  5. Paracoccidioidomycosis: an update. Brummer, E., Castaneda, E., Restrepo, A. Clin. Microbiol. Rev. (1993) [Pubmed]
  6. Chemokine production and leukocyte recruitment to the lungs of Paracoccidioides brasiliensis-infected mice is modulated by interferon-gamma. Souto, J.T., Aliberti, J.C., Campanelli, A.P., Livonesi, M.C., Maffei, C.M., Ferreira, B.R., Travassos, L.R., Martinez, R., Rossi, M.A., Silva, J.S. Am. J. Pathol. (2003) [Pubmed]
  7. Interferon-gamma and tumor necrosis factor-alpha determine resistance to Paracoccidioides brasiliensis infection in mice. Souto, J.T., Figueiredo, F., Furlanetto, A., Pfeffer, K., Rossi, M.A., Silva, J.S. Am. J. Pathol. (2000) [Pubmed]
  8. Differential expression of an hsp70 gene during transition from the mycelial to the infective yeast form of the human pathogenic fungus Paracoccidioides brasiliensis. da Silva, S.P., Borges-Walmsley, M.I., Pereira, I.S., Soares, C.M., Walmsley, A.R., Felipe, M.S. Mol. Microbiol. (1999) [Pubmed]
  9. Identification of sialic acids on the cell surface of hyphae and yeast forms of the human pathogen Paracoccidioides brasiliensis. Soares, R.M., Alviano, C.S., Angluster, J., Travassos, L.R. FEMS Microbiol. Lett. (1993) [Pubmed]
  10. Chronic murine paracoccidioidomycosis: effect of ketoconazole on clearance of Paracoccidioides brasiliensis and immune response. Hoyos, G.L., McEwen, J.G., Brummer, E., Castañeda, E., Restrepo, A., Stevens, D.A. Sabouraudia. (1984) [Pubmed]
  11. Isoenzyme profile of Paracoccidioides brasiliensis. Svidzinsky, T.I., Camargo, Z.P. J. Med. Vet. Mycol. (1995) [Pubmed]
  12. Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. Campanelli, A.P., Martins, G.A., Souto, J.T., Pereira, M.S., Livonesi, M.C., Martinez, R., Silva, J.S. J. Infect. Dis. (2003) [Pubmed]
  13. Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus Paracoccidioides brasiliensis. Morais, F.V., Barros, T.F., Fukada, M.K., Cisalpino, P.S., Puccia, R. J. Clin. Microbiol. (2000) [Pubmed]
  14. The kex2 gene from the dimorphic and human pathogenic fungus Paracoccidioides brasiliensis. Venancio, E.J., Daher, B.S., Andrade, R.V., Soares, C.M., Pereira, I.S., Felipe, M.S. Yeast (2002) [Pubmed]
  15. Hygromycin B-resistance phenotype acquired in Paracoccidioides brasiliensis via plasmid DNA integration. Soares, R.d.e. .B., Velho, T.A., De Moraes, L.M., Azevedo, M.O., Soares, C.M., Felipe, M.S. Med. Mycol. (2005) [Pubmed]
  16. In vivo and in vitro activation of pulmonary macrophages by IFN-gamma for enhanced killing of Paracoccidioides brasiliensis or Blastomyces dermatitidis. Brummer, E., Hanson, L.H., Restrepo, A., Stevens, D.A. J. Immunol. (1988) [Pubmed]
  17. Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide. Gonzalez, A., Aristizábal, B.H., Gómez, E.C., Restrepo, A., Cano, L.E. Am. J. Trop. Med. Hyg. (2004) [Pubmed]
  18. alpha-galf I -->6-alpha-mannopyranoside side chains in Paracoccidioides brasiliensis cell wall are shared by members of the Onygenales, but not by galactomannans of other fungal genera. San-Blas, G., Prieto, A., Bernabé, M., Ahrazem, O., Moreno, B., Leal, J.A. Med. Mycol. (2005) [Pubmed]
  19. Influence of the genetic background on the pattern of lesions developed by resistant and susceptible mice infected with Paracoccidioides brasiliensis. Xidieh, C.F., Lenzi, H.L., Calich, V.L., Burger, E. Med. Microbiol. Immunol. (Berl.) (1999) [Pubmed]
  20. Histochemical localization of succinate dehydrogenase in the mitochondria of Paracoccidioides brasiliensis. Campo-Aasen, I. Sabouraudia. (1985) [Pubmed]
  21. Effects of amphotericin B and three azole derivatives on the lipids of yeast cells of Paracoccidioides brasiliensis. Hahn, R.C., Hamdan, J.S. Antimicrob. Agents Chemother. (2000) [Pubmed]
  22. In vitro antifungal activity of Micafungin (FK463) against dimorphic fungi: comparison of yeast-like and mycelial forms. Nakai, T., Uno, J., Ikeda, F., Tawara, S., Nishimura, K., Miyaji, M. Antimicrob. Agents Chemother. (2003) [Pubmed]
  23. Inhibition of growth of the dimorphic fungus Paracoccidioides brasiliensis by ajoene. San-Blas, G., San-Blas, F., Gil, F., Mariño, L., Apitz-Castro, R. Antimicrob. Agents Chemother. (1989) [Pubmed]
  24. Estradiol-binding proteins from mycelial and yeast-form cultures of Paracoccidioides brasiliensis. Stover, E.P., Schär, G., Clemons, K.V., Stevens, D.A., Feldman, D. Infect. Immun. (1986) [Pubmed]
  25. S-Adenosyl-L-methionine inhibitors delta(24)-sterol methyltransferase and delta(24(28))-sterol methylreductase as possible agents against Paracoccidioides brasiliensis. Visbal, G., Alvarez, A., Moreno, B., San-Blas, G. Antimicrob. Agents Chemother. (2003) [Pubmed]
  26. Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response. Pina, A., Valente-Ferreira, R.C., Molinari-Madlum, E.E., Vaz, C.A., Keller, A.C., Calich, V.L. Infect. Immun. (2004) [Pubmed]
  27. Cloning and characterization of a LON gene homologue from the human pathogen Paracoccidioides brasiliensis. Barros, T.F., Puccia, R. Yeast (2001) [Pubmed]
  28. Patients with active infection with Paracoccidioides brasiliensis present a Th2 immune response characterized by high Interleukin-4 and Interleukin-5 production. Marques Mello, L., Silva-Vergara, M.L., Rodrigues, V. Hum. Immunol. (2002) [Pubmed]
  29. Effect of cytokines on antifungal activity of human polymorphonuclear leucocytes against yeast cells of Paracoccidioides brasiliensis. Kurita, N., Oarada, M., Miyaji, M., Ito, E. Med. Mycol. (2000) [Pubmed]
  30. The PbMDJ1 gene belongs to a conserved MDJ1/LON locus in thermodimorphic pathogenic fungi and encodes a heat shock protein that localizes to both the mitochondria and cell wall of Paracoccidioides brasiliensis. Batista, W.L., Matsuo, A.L., Ganiko, L., Barros, T.F., Veiga, T.R., Freymüller, E., Puccia, R. Eukaryotic Cell (2006) [Pubmed]
  31. Sensitive immunoradiometric assay for the detection of Paracoccidioides brasiliensis antigens in human sera. Ferreira-da-Cruz, M.F., Galvão-Castro, B., Daniel-Ribeiro, C.T. J. Clin. Microbiol. (1991) [Pubmed]
  32. Molecular cloning and characterization of a glucan synthase gene from the human pathogenic fungus Paracoccidioides brasiliensis. Pereira, M., Felipe, M.S., Brígido, M.M., Soares, C.M., Azevedo, M.O. Yeast (2000) [Pubmed]
  33. Differential expression of chitin synthase genes during temperature-induced dimorphic transitions in Paracoccidioides brasiliensis. Niño-Vega, G.A., Munro, C.A., San-Blas, G., Gooday, G.W., Gow, N.A. Med. Mycol. (2000) [Pubmed]
  34. A morphological mutant of Paracoccidioides brasiliensis strain IVIC Pb9. Isolation and wall characterization. San-Blas, F., San-Blas, G., Cova, L.J. J. Gen. Microbiol. (1976) [Pubmed]
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