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Chemical Compound Review

IMAGENT     1-bromo- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8, 8,8...

Synonyms: LiquiVent, Oxygent, Perflubron, PFOB, Imagent BP, ...
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Disease relevance of Imagent GI


High impact information on Imagent GI


Chemical compound and disease context of Imagent GI


Biological context of Imagent GI

  • PLV changed pericardial pressure or cardiac output minimally (at PEEP(0), GV: Pperi = -1.7 +/- 0.6 mm Hg, CO = 3. 2 +/- 0.1 L/m; 10 ml/kg perflubron: Pperi = -1.3 +/- 0.6 mm Hg, CO = 3.4 +/- 0.2 L/m; 30 ml/kg perflubron: Pperi = -1.6 +/- 0.7 mm Hg, CO = 3.4 +/- 0.2 L/m; all mean +/- SEM) [14].
  • These studies demonstrate that use of perflubron enhances transgene expression in lungs of animals with a chronic alveolar filling process [15].
  • Total lung expression of the beta-Gal reporter gene was increased two- to three-fold by instillation of the virus (10(11) particles/kg body weight) in saline (1.5 ml/kg) simultaneously with perflubron liquid (15 ml/kg) compared to virus+saline alone (control) [16].
  • All tidal volumes measured with perfluorooctyl bromide vapor were increased compared with control [17].
  • There was no difference in bacterial viability between the control and perflubron-exposed bacteria (n = 5) [18].

Anatomical context of Imagent GI

  • In animals receiving either vector alone or vector with perflubron, in situ beta-galactosidase expression was observed in a variety of cells including large airway, bronchiolar, and alveolar epithelial cells [4].
  • We examined the effect of instilled perflubron (LiquiVent) on the transport properties of alveolar epithelium in anesthetized rats [19].
  • Because perflubron is expected to be used most frequently on surgical patients in a hemodiluted state, we conducted all tests on human erythrocytes suspended in plasma at a hemoglobin concentration standardized to 70 g/L (7 g/dL) and with oxyhemoglobin saturation set at 97% [20].
  • Massage of the injection site increased delivery of the perflubron emulsion to regional lymph nodes [21].
  • The sonographer, unaware of rabbit assignment, imaged both kidneys in 17 rabbits before and 24 hours after the temporary occlusion of one of the renal arteries and then again after the infusion of up to 5 ml/kg of PFOB (N = 10) or saline (N = 7) [22].

Associations of Imagent GI with other chemical compounds


Gene context of Imagent GI


Analytical, diagnostic and therapeutic context of Imagent GI


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  2. Positive end-expiratory pressure improves gas exchange and pulmonary mechanics during partial liquid ventilation. Kirmse, M., Fujino, Y., Hess, D., Kacmarek, R.M. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  3. Independent and combined effects of inhaled nitric oxide, liquid perfluorochemical, and high-frequency oscillatory ventilation in premature lambs with respiratory distress syndrome. Kinsella, J.P., Parker, T.A., Galan, H., Sheridan, B.C., Abman, S.H. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  4. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates. Weiss, D.J., Baskin, G.B., Shean, M.K., Blanchard, J.L., Kolls, J.K. Mol. Ther. (2002) [Pubmed]
  5. Effect of partial liquid ventilation on pulmonary vascular permeability and edema after experimental acute lung injury. Lange, N.R., Kozlowski, J.K., Gust, R., Shapiro, S.D., Schuster, D.P. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  6. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. The LiquiVent Study Group. Leach, C.L., Greenspan, J.S., Rubenstein, S.D., Shaffer, T.H., Wolfson, M.R., Jackson, J.C., DeLemos, R., Fuhrman, B.P. N. Engl. J. Med. (1996) [Pubmed]
  7. Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation. Haeberle, H.A., Nesti, F., Dieterich, H.J., Gatalica, Z., Garofalo, R.P. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  8. Prospective, randomized, controlled pilot study of partial liquid ventilation in adult acute respiratory distress syndrome. Hirschl, R.B., Croce, M., Gore, D., Wiedemann, H., Davis, K., Zwischenberger, J., Bartlett, R.H. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  9. Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Teicher, B.A., Holden, S.A., Ara, G., Dupuis, N.P., Liu, F., Yuan, J., Ikebe, M., Kakeji, Y. Int. J. Cancer (1995) [Pubmed]
  10. Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone. Kemming, G.I., Meisner, F.G., Wojtczyk, C.J., Packert, K.B., Minor, T., Thiel, M., Tillmanns, J., Meier, J., Bottino, D., Keipert, P.E., Faithfull, S., Habler, O.P. Shock (2005) [Pubmed]
  11. Tumour oxygenation, radiosensitivity, and necrosis before and/or after nicotinamide, carbogen and perflubron emulsion administration. Thomas, C.D., Prade, M., Guichard, M. Int. J. Radiat. Biol. (1995) [Pubmed]
  12. Effects of perfluorooctylbromide and vitamin E on ischemia induced retinal oxidative tissue damage. Augustin, A.J., Spitznas, M., Koch, F., Grus, F., Lutz, J. Exp. Eye Res. (1998) [Pubmed]
  13. Selective aortic arch perfusion during cardiac arrest: enhanced resuscitation using oxygenated perflubron emulsion, with and without aortic arch epinephrine. Manning, J.E., Batson, D.N., Payne, F.B., Adam, N., Murphy, C.A., Perretta, S.G., Norfleet, E.A. Annals of emergency medicine. (1997) [Pubmed]
  14. Accuracy of hemodynamic measurements during partial liquid ventilation with perflubron. Fessler, H.E., Pearse, D. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  15. Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling. Weiss, D.J., Strandjord, T.P., Liggitt, D., Clark, J.G. Hum. Gene Ther. (1999) [Pubmed]
  16. Enhanced distribution of adenovirus-mediated gene transfer to lung parenchyma by perfluorochemical liquid. Lisby, D.A., Ballard, P.L., Fox, W.W., Wolfson, M.R., Shaffer, T.H., Gonzales, L.W. Hum. Gene Ther. (1997) [Pubmed]
  17. Effect of perfluorocarbon (perfluorooctyl bromide) vapor on tidal volume measurement during partial liquid ventilation. Davies, M.W., Dunster, K.R. Crit. Care Med. (2002) [Pubmed]
  18. The risk of nosocomial pneumonia is not increased during partial liquid ventilation. Sajan, I., Scannapieco, F.A., Fuhrman, B.P., Steinhorn, D.M. Crit. Care Med. (1999) [Pubmed]
  19. Alveolar permeability and liquid absorption during partial liquid ventilation of rats with perflubron. Ricard, J.D., Martin-Lefèvre, L., Dreyfuss, D., Saumon, G. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  20. CO-oximetry interference by perflubron emulsion: comparison of hemolyzing and nonhemolyzing instruments. Shepherd, A.P., Steinke, J.M. Clin. Chem. (1998) [Pubmed]
  21. Percutaneous CT lymphography with perflubron: imaging efficacy in rabbits and monkeys. Wolf, G.L., Rogowska, J., Hanna, G.K., Halpern, E.F. Radiology. (1994) [Pubmed]
  22. Potential role of PFOB enhanced sonography of the kidney. I. Detection of renal function and acute tubular necrosis. Munzing, D., Mattrey, R.F., Reznik, V.M., Mitten, R.M., Peterson, T. Kidney Int. (1991) [Pubmed]
  23. Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation. Ellena, J.F., Obraztsov, V.V., Cumbea, V.L., Woods, C.M., Cafiso, D.S. J. Med. Chem. (2002) [Pubmed]
  24. Perfluorochemical liquids modulate cell-mediated inflammatory responses. Nakstad, B., Wolfson, M.R., Shaffer, T.H., Kähler, H., Lindemann, R., Fugelseth, D., Lyberg, T. Crit. Care Med. (2001) [Pubmed]
  25. End-expiratory lung volumes and density distribution patterns during partial liquid ventilation in healthy and oleic acid-injured sheep: a computed tomography study. Luecke, T., Meinhardt, J.P., Herrmann, P., Klemm, S., Weiss, A., Weisser, G., Hirschl, R.B., Quintel, M. Crit. Care Med. (2003) [Pubmed]
  26. Treatment of pulmonary hypertension and hypoxia due to oleic acid induced lung injury with intratracheal prostaglandin E1 during partial liquid ventilation. Nakazawa, K., Uchida, T., Matsuzawa, Y., Yokoyama, K., Makita, K., Amaha, K. Anesthesiology (1998) [Pubmed]
  27. Modulation of tumor oxygenation and radiosensitivity by a perfluorooctylbromide emulsion. Rockwell, S., Kelley, M., Irvin, C.G., Hughes, C.S., Porter, E., Yabuki, H., Fischer, J.J. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1991) [Pubmed]
  28. Inhibition of endotoxin-mediated activation of endothelial cells by a perfluorocarbon emulsion. Lane, T., Smith, D., Wancewicz, E., Funk, R. Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology. (1993) [Pubmed]
  29. Partial liquid ventilation decreases the inflammatory response in the alveolar environment of trauma patients. Croce, M.A., Fabian, T.C., Patton, J.H., Melton, S.M., Moore, M., Trenthem, L.L. The Journal of trauma. (1998) [Pubmed]
  30. Neonates with congenital diaphragmatic hernia: radiographic findings during partial liquid ventilation. Garver, K.A., Kazerooni, E.A., Hirschl, R.B., DiPietro, M.A. Radiology. (1996) [Pubmed]
  31. Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European phase 3 study. Spahn, D.R., Waschke, K.F., Standl, T., Motsch, J., Van Huynegem, L., Welte, M., Gombotz, H., Coriat, P., Verkh, L., Faithfull, S., Keipert, P. Anesthesiology (2002) [Pubmed]
  32. Dose-response effect of perfluorocarbon administration on lung microvascular permeability in rats. Ricard, J.D., Dreyfuss, D., Laissy, J.P., Saumon, G. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  33. Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests. Ma, Z., Monk, T.G., Goodnough, L.T., McClellan, A., Gawryl, M., Clark, T., Moreira, P., Keipert, P.E., Scott, M.G. Clin. Chem. (1997) [Pubmed]
  34. Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: chest radiographic appearances. Gross, G.W., Greenspan, J.S., Fox, W.W., Rubenstein, S.D., Wolfson, M.R., Shaffer, T.H. Radiology. (1995) [Pubmed]
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