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MeSH Review

Mediterranean Sea

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Disease relevance of Mediterranean Sea


High impact information on Mediterranean Sea

  • It resulted from the closure of marine gateways between the Atlantic Ocean and the Mediterranean Sea, the causes of which remain enigmatic [6].
  • A common glucose-6-phosphate dehydrogenase (G6PD) variant characterized by severe enzyme deficiency and B-like electrophoretic mobility is called "G6PD-Mediterranean" because it is found in different populations around the Mediterranean Sea [7].
  • The instrument implemented on top of a YOYO vertical eulerian profiler was then deployed successfully in the northwestern Mediterranean Sea acquiring 30 nitrate profiles between 200 and 1100 m over a 15-day period [8].
  • Biogeographic patterns of the Symphodus species group and the genus Labrus are dominated by speciation events driven by the closing and opening of the Mediterranean Sea and periodic glaciation events during the past 1 million years [9].
  • This annual herb grows in countries bordering the Mediterranean Sea and India. Thymoquinone (TQ) is the bioactive constituent of the volatile oil of black seed [10].

Biological context of Mediterranean Sea


Anatomical context of Mediterranean Sea

  • The paper reports a histological and immunohistochemical description of oocyte growth and ultrastructural aspects of zona radiata (ZR) formation as well as the relationship between plasma estradiol-17beta, (E2) levels and ovarian development in swordfish (Xiphias gladius L.) from the Mediterranean Sea [15].

Associations of Mediterranean Sea with chemical compounds

  • P was found to stimulate bacterial production (BP) in 13 out of 18 experiments, in the eastern and in the western Mediterranean Sea [16].
  • Irgarol 1051 was detected at ng l(-1) levels in the Barcelona marina (northwestern Mediterranean Sea) [17].
  • A new sulfate-reducing bacterium, strain 86FS1, was isolated from a deep-sea sediment in the western Mediterranean Sea with sodium lactate as electron and carbon source [18].
  • Caulerpenyne (Cyn), the major secondary metabolite synthesized by the green alga Caulerpa taxifolia proliferating in the Mediterranean Sea, is a cytotoxic sesquiterpene [19].
  • The effect of phosphate (P), nitrate (N), and organic carbon (C, glucose) enrichment on heterotrophic bacterial production was examined along two longitudinal transects covering the whole Mediterranean Sea during June and September 1999 [16].

Gene context of Mediterranean Sea

  • The spectrum of PAH gene mutations in Sicily reflects the complex demographic history of this island at the crossroad of prehistoric and historical migrations in the Mediterranean sea [20].
  • METHODS: The POLA study is a population-based study taking place in the town of Sète, located on the French Mediterranean Sea border [21].
  • Glucose-6-phosphate dehydrogenase Mediterranean (G6PD Med) is a common G6PD variant around the Mediterranean Sea characterized by severe enzyme deficiency and B-like electrophoretic mobility [22].
  • No substructuring was found between samples within the Mediterranean Sea, theta = 0.003 and RST = 0.007 (P > 0.05) [23].
  • Our data have evidenced a latitudinal cline at loci Gapdh and Gpi-2 within the Mediterranean Sea, with a further steep change across the Almeria-Oran front [24].


  1. Thiocapsa marina sp. nov., a novel, okenone-containing, purple sulfur bacterium isolated from brackish coastal and marine environments. Caumette, P., Guyoneaud, R., Imhoff, J.F., Süling, J., Gorlenko, V. Int. J. Syst. Evol. Microbiol. (2004) [Pubmed]
  2. Role of endosymbiotic zooxanthellae and coral mucus in the adhesion of the coral-bleaching pathogen Vibrio shiloi to its host. Banin, E., Israely, T., Fine, M., Loya, Y., Rosenberg, E. FEMS Microbiol. Lett. (2001) [Pubmed]
  3. Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea). Novelli, A.A., Argese, E., Tagliapietra, D., Bettiol, C., Ghirardini, A.V. Environ. Toxicol. Chem. (2002) [Pubmed]
  4. Reverse hybridization vs. DNA sequencing in the molecular diagnosis of Familial Mediterranean fever. Delague, V., Kriegshäuser, G., Oberkanins, C., Mégarbané, A. Genet. Test. (2004) [Pubmed]
  5. Abnormally high polychlorinated biphenyl levels in striped dolphins (Stenella coeruleoalba) affected by the 1990-1992 Mediterranean epizootic. Aguilar, A., Borrell, A. Sci. Total Environ. (1994) [Pubmed]
  6. Deep roots of the Messinian salinity crisis. Duggen, S., Hoernle, K., van den Bogaard, P., Rüpke, L., Morgan, J.P. Nature (2003) [Pubmed]
  7. Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East. Kurdi-Haidar, B., Mason, P.J., Berrebi, A., Ankra-Badu, G., al-Ali, A., Oppenheim, A., Luzzatto, L. Am. J. Hum. Genet. (1990) [Pubmed]
  8. An autonomous nutrient analyzer for oceanic long-term in situ biogeochemical monitoring. Thouron, D., Vuillemin, R., Philippon, X., Lourenço, A., Provost, C., Cruzado, A., Garçon, V. Anal. Chem. (2003) [Pubmed]
  9. Phylogenetic relationships, evolution of broodcare behavior, and geographic speciation in the wrasse tribe Labrini. Hanel, R., Westneat, M.W., Sturmbauer, C. J. Mol. Evol. (2002) [Pubmed]
  10. Thymoquinone: A promising anti-cancer drug from natural sources. Gali-Muhtasib, H., Roessner, A., Schneider-Stock, R. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  11. Discerning between recurrent gene flow and recent divergence under a finite-site mutation model applied to North Atlantic and Mediterranean Sea fin whale (Balaenoptera physalus) populations. Palsbøll, P.J., Bérubé, M., Aguilar, A., Notarbartolo-Di-Sciara, G., Nielsen, R. Evolution (2004) [Pubmed]
  12. Study of genetic diversity of eukaryotic picoplankton in different oceanic regions by small-subunit rRNA gene cloning and sequencing. Díez, B., Pedrós-Alió, C., Massana, R. Appl. Environ. Microbiol. (2001) [Pubmed]
  13. Microsatellite and mitochondrial DNA analyses of Atlantic bluefin tuna (Thunnus thynnus thynnus) population structure in the Mediterranean Sea. Carlsson, J., McDowell, J.R., Díaz-Jaimes, P., Carlsson, J.E., Boles, S.B., Gold, J.R., Graves, J.E. Mol. Ecol. (2004) [Pubmed]
  14. Genetic structure of Mediterranean populations revealed by Y-chromosome haplotype analysis. Quintana-Murci, L., Veitia, R., Fellous, M., Semino, O., Poloni, E.S. Am. J. Phys. Anthropol. (2003) [Pubmed]
  15. Histological and immunohistochemical investigation on ovarian development and plasma estradiol levels in the swordfish (Xiphias gladius L.). Corriero, A., Acone, F., Desantis, S., Zubani, D., Deflorio, M., Ventriglia, G., Bridges, C.R., Labate, M., Palmieri, G., McAllister, B.G., Kime, D.E., De Metrio, G. European journal of histochemistry : EJH. (2004) [Pubmed]
  16. Longitudinal and vertical trends of bacterial limitation by phosphorus and carbon in the Mediterranean Sea. Van Wambeke, F., Christaki, U., Giannakourou, A., Moutin, T., Souvemerzoglou, K. Microb. Ecol. (2002) [Pubmed]
  17. Development and application of immunoaffinity chromatography for the determination of the triazinic biocides in seawater. Carrasco, P.B., Escolà, R., Marco, M.P., Bayona, J.M. Journal of chromatography. A. (2001) [Pubmed]
  18. Desulfobulbus mediterraneus sp. nov., a sulfate-reducing bacterium growing on mono- and disaccharides. Sass, A., Rütters, H., Cypionka, H., Sass, H. Arch. Microbiol. (2002) [Pubmed]
  19. Caulerpenyne interferes with microtubule-dependent events during the first mitotic cycle of sea urchin eggs. Pesando, D., Huitorel, P., Dolcini, V., Amade, P., Girard, J.P. Eur. J. Cell Biol. (1998) [Pubmed]
  20. PAH gene mutations in the Sicilian population: association with minihaplotypes and expression analysis. Mirisola, M.G., Cali, F., Gloria, A., Schinocca, P., D'Amato, M., Cassara, G., Leo, G.D., Palillo, L., Meli, C., Romano, V. Mol. Genet. Metab. (2001) [Pubmed]
  21. Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l'Age. Delcourt, C., Diaz, J.L., Ponton-Sanchez, A., Papoz, L. Arch. Ophthalmol. (1998) [Pubmed]
  22. Glucose-6-phosphate dehydrogenase nucleotide 1311 polymorphism in central Italy (Marche Region). Ruzzo, A., Ninfali, P., Magnani, M. Enzyme Protein (1993) [Pubmed]
  23. Macrogeographical population differentiation in oceanic environments: a case study of European hake (Merluccius merluccius), a commercially important fish. Lundy, C.J., Moran, P., Rico, C., Milner, R.S., Hewitt, G.M. Mol. Ecol. (1999) [Pubmed]
  24. Genetic structure and environmental heterogeneity in the European hake (Merluccius merluccius). Cimmaruta, R., Bondanelli, P., Nascetti, G. Mol. Ecol. (2005) [Pubmed]
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