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Disease relevance of Cholelithiasis


Psychiatry related information on Cholelithiasis


High impact information on Cholelithiasis


Chemical compound and disease context of Cholelithiasis


Biological context of Cholelithiasis


Anatomical context of Cholelithiasis


Gene context of Cholelithiasis

  • Characterization of the pathophysiologic roles of Lith3 and the new biliary mucin gene Glycam1 might provide insights into primary defects of human cholelithiasis and lead to new therapeutic strategies for prestone intervention [25].
  • Hence, mouse gallbladder K8/K18/K19 expression is induced in response to cholelithiasis injury [26].
  • In contrast, the Cpe (fat) mutation enhanced the prevalence of cholelithiasis markedly when compared with the background strain [27].
  • MATERIALS AND METHODS: Surgical liver biopsies were obtained from 11 patients with untreated cholesterol cholelithiasis and nine gallstone-free subjects; mRNA levels of cholesterol 7alpha-hydroxylase (CYP7A1) and related nuclear receptors and coactivators were assayed by quantitative real-time RT-PCR [28].
  • The bilirubin levels for the cholelithiasis patients with the homozygous variant-UGT1A1 gene were significantly different from the control analog (18.0+/-6.5 and 12.7+/-2.9 micromol/L, respectively; P<0.001, Student's t test) [29].

Analytical, diagnostic and therapeutic context of Cholelithiasis


  1. Identification of patients with cholesterol or pigment gallstones by discriminant analysis of radiographic features. Dolgin, S.M., Schwartz, J.S., Kressel, H.Y., Soloway, R.D., Miller, W.T., Trotman, B.W., Soloway, A.S., Good, L.I. N. Engl. J. Med. (1981) [Pubmed]
  2. Abnormal biliary lipid composition in cystic fibrosis. Effect of pancreatic enzymes. Roy, C.C., Weber, A.M., Morin, C.L., Combes, J.C., Nusslé, D., Mégevand, A., Lasalle, R. N. Engl. J. Med. (1977) [Pubmed]
  3. Effects of diabetes mellitus on cholesterol metabolism in man. Bennion, L.J., Grundy, S.M. N. Engl. J. Med. (1977) [Pubmed]
  4. Treatment of biliary colic with diclofenac: a randomized, double-blind, placebo-controlled study. Akriviadis, E.A., Hatzigavriel, M., Kapnias, D., Kirimlidis, J., Markantas, A., Garyfallos, A. Gastroenterology (1997) [Pubmed]
  5. A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. Lucena, J.F., Herrero, J.I., Quiroga, J., Sangro, B., Garcia-Foncillas, J., Zabalegui, N., Sola, J., Herraiz, M., Medina, J.F., Prieto, J. Gastroenterology (2003) [Pubmed]
  6. Different susceptibilities to the formation of cholesterol gallstones in mice. Alexander, M., Portman, O.W. Hepatology (1987) [Pubmed]
  7. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. Wang, D.Q., Schmitz, F., Kopin, A.S., Carey, M.C. J. Clin. Invest. (2004) [Pubmed]
  8. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Wittenburg, H., Lyons, M.A., Li, R., Churchill, G.A., Carey, M.C., Paigen, B. Gastroenterology (2003) [Pubmed]
  9. ABCB4 gene mutation-associated cholelithiasis in adults. Rosmorduc, O., Hermelin, B., Boelle, P.Y., Parc, R., Taboury, J., Poupon, R. Gastroenterology (2003) [Pubmed]
  10. Aspirin does not inhibit cholesterol cholelithiasis in two established animal models. Cohen, B.I., Mosbach, E.H., Ayyad, N., Yoshii, M., McSherry, C.K. Gastroenterology (1991) [Pubmed]
  11. Cholesterol crystals and the formation of cholesterol gallstones. Sedaghat, A., Grundy, S.M. N. Engl. J. Med. (1980) [Pubmed]
  12. Toxicity of chenodeoxycholic acid in the rhesus monkey. Dyrszka, H., Chen, T., Salen, G., Mosbach, E.H. Gastroenterology (1975) [Pubmed]
  13. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Messing, B., Bories, C., Kunstlinger, F., Bernier, J.J. Gastroenterology (1983) [Pubmed]
  14. Estrogen predisposes to cholecystectomy but not to stones. Everson, R.B., Byar, D.P., Bischoff, A.J. Gastroenterology (1982) [Pubmed]
  15. Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. LaRusso, N.F., Szczepanik, P.A., Hofmann, A.F. Gastroenterology (1977) [Pubmed]
  16. Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Miquel, J.F., Covarrubias, C., Villaroel, L., Mingrone, G., Greco, A.V., Puglielli, L., Carvallo, P., Marshall, G., Del Pino, G., Nervi, F. Gastroenterology (1998) [Pubmed]
  17. Kinetics of cholesterol and bile acids in patients with cholesterol cholelithiasis. Hepner, G.W., Quarfordt, S.H. Gastroenterology (1975) [Pubmed]
  18. Melatonin prevents pigment gallstone formation induced by bile duct ligation in guinea pigs. Shiesh, S.C., Chen, C.Y., Lin, X.Z., Liu, Z.A., Tsao, H.C. Hepatology (2000) [Pubmed]
  19. Hepatic canalicular membrane transport of bile salt in C57L/J and AKR/J mice: implications for cholesterol gallstone formation. Hoda, F., Green, R.M. J. Membr. Biol. (2003) [Pubmed]
  20. The effect of loss of gallbladder function on biliary lipid composition in subjects with cholesterol gallstones. Redinger, R.N. Gastroenterology (1976) [Pubmed]
  21. Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis. Lee, S.P. J. Pathol. (1981) [Pubmed]
  22. Experimental cholelithiasis in the ground squirrel. MacPherson, B.R., Pemsingh, R.S., Scott, G.W. Lab. Invest. (1987) [Pubmed]
  23. Pathology of the gallbladder in gallstone pancreatitis. Chitkara, Y.K. Arch. Pathol. Lab. Med. (1995) [Pubmed]
  24. Dominant lethal study of alpha-asarone in male mice. Chamorro, G., Garduño, L., Martínez, E., Madrigal, E., Tamariz, J., Salazar, M. Toxicol. Lett. (1998) [Pubmed]
  25. Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice. Lammert, F., Wang, D.Q., Wittenburg, H., Bouchard, G., Hillebrandt, S., Taenzler, B., Carey, M.C., Paigen, B. Hepatology (2002) [Pubmed]
  26. Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury. Tao, G.Z., Toivola, D.M., Zhong, B., Michie, S.A., Resurreccion, E.Z., Tamai, Y., Taketo, M.M., Omary, M.B. J. Cell. Sci. (2003) [Pubmed]
  27. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. Bouchard, G., Johnson, D., Carver, T., Paigen, B., Carey, M.C. J. Lipid Res. (2002) [Pubmed]
  28. Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. Bertolotti, M., Gabbi, C., Anzivino, C., Mitro, N., Godio, C., De Fabiani, E., Crestani, M., Del Puppo, M., Ricchi, M., Carulli, L., Rossi, A., Loria, P., Carulli, N. Eur. J. Clin. Invest. (2006) [Pubmed]
  29. Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis. Huang, Y.Y., Huang, C.S., Yang, S.S., Lin, M.S., Huang, M.J., Huang, C.S. World J. Gastroenterol. (2005) [Pubmed]
  30. Gallbladder disease in patients on long-term parenteral nutrition. Roslyn, J.J., Pitt, H.A., Mann, L.L., Ament, M.E., DenBesten, L. Gastroenterology (1983) [Pubmed]
  31. Ultrastructural evidence of intrahepatic cholestasis before and after chenodeoxycholic acid therapy in patients with cholelithiasis: the national cooperative gallstone study. Phillips, M.J., Fisher, R.L., Anderson, D.W., Lan, S.P., Lachin, J.M., Boyer, J.L. Hepatology (1983) [Pubmed]
  32. Gallbladder perforation and bile leakage: percutaneous treatment. vanSonnenberg, E., D'Agostino, H.B., Casola, G., Hoyt, D.B., Lurie, A., Varney, R.R. Radiology. (1991) [Pubmed]
  33. Effect of castration and hormonal supplementation on cholesterol cholelithiasis in the male hamster. Ohshima, A., Cohen, B.I., Ayyad, N., Mosbach, E.H. Lipids (1996) [Pubmed]
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