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Chemical Compound Review

Alevaire     methanal; oxirane; 4-(2,4,4...

Synonyms: Enuclene, Tiloxapol, Tyloxapol, Tyloxypal, Superinone, ...
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Disease relevance of NSC7248


High impact information on NSC7248

  • Results are compatible with the hypothesis that the potentiating effects of Triton WR-1339 on liver damage caused by DMN and other hepatotoxins were due to a modification of the response of liver cells to injury [6].
  • In these experiments, we tested two hypothesis: first, that Triton WR-1339, a nonionic detergent which is sequestered in hepatocyte lysosomes, undergoes biliary excretion; and second, that Triton WR-1339, which also alters serum lipid levels and modifies hepatic catabolism of lipoproteins, affects the biliary output of proteins and lipids [7].
  • Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339 [8].
  • Despite their enrichment in DPPC Survanta and Exosurf exhibited poor surface activity because of low or absent SP-B/C [9].
  • We investigated these parameters in Alveofact, Curosurf, Exosurf, and Survanta, and compared them with native bovine (NBS) and porcine (NPS) surfactant [9].

Chemical compound and disease context of NSC7248


Biological context of NSC7248

  • Exosurf was ineffective in the treatment of wood smoke inhalation [15].
  • Formation of triton WR 1339-filled rat liver lysosomes. II. Involvement of autophagy and of pre-existing lysosomes [16].
  • The synthetic surfactant preparation Exosurf containing L-alpha-phosphatidylcholine-dipalmitoyl (DPPC) as the sole lipid ingredient had no statistically significant effect on polymer- and lipid-mediated transfection [17].
  • Whereas both 3 and 1 reduced hypercholesterolemic and hypertriglyceridemic serum levels in the Triton WR-1339 induced hyperlipidemic Sprague-Dawley rat to normal, the hydrolysis product of 3, namely 5-chloro-3(2'-hydroxyethoxy)-2-benzofurancarboxylic acid (4), was found to be inactive [18].
  • Hepatic TG secretion rates, measured in vivo after blocking lipolysis with Triton WR-1339 in fasting animals, were increased by 33% in both ADR and NA rats as compared to controls (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)[19]

Anatomical context of NSC7248


Associations of NSC7248 with other chemical compounds


Gene context of NSC7248


Analytical, diagnostic and therapeutic context of NSC7248

  • Greater than 95% of total proteolysis in homogenates, measured at 37 degrees C from free amino acid generation or the release of [14C]valine in previously labeled livers, was associated with particulate fractions, and it paralleled lysosomal markers closely during graded differential centrifugation after Triton WR-1339 loading [31].
  • In fact, immunofluorescence studies and Triton WR-1339 shift experiments suggest a lysosomal localization for this enzyme [32].
  • We conclude that Exosurf is more effective when administered by lavage in this lung injury model [4].
  • Exosurf, an artificial surfactant, was administered after acute lung injury induced by saline lung lavage in neonatal piglets [4].
  • 1. Lipoprotein lipase activity was measured in heart homogenates and in heparin-releasable and non-releasable fractions of isolated perfused rat hearts, after the intravenous injection of Triton WR-1339 [33].


  1. A controlled trial of synthetic surfactant in infants weighing 1250 g or more with respiratory distress syndrome. The American Exosurf Neonatal Study Group I, and the Canadian Exosurf Neonatal Study Group. Long, W., Corbet, A., Cotton, R., Courtney, S., McGuiness, G., Walter, D., Watts, J., Smyth, J., Bard, H., Chernick, V. N. Engl. J. Med. (1991) [Pubmed]
  2. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group. Anzueto, A., Baughman, R.P., Guntupalli, K.K., Weg, J.G., Wiedemann, H.P., Raventós, A.A., Lemaire, F., Long, W., Zaccardelli, D.S., Pattishall, E.N. N. Engl. J. Med. (1996) [Pubmed]
  3. Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoprotein B lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity, and insulin resistance. Siri, P., Candela, N., Zhang, Y.L., Ko, C., Eusufzai, S., Ginsberg, H.N., Huang, L.S. J. Biol. Chem. (2001) [Pubmed]
  4. Physiologic response and lung distribution of lavage versus bolus Exosurf in piglets with acute lung injury. Balaraman, V., Sood, S.L., Finn, K.C., Hashiro, G., Uyehara, C.F., Easa, D. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  5. Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum. Ghio, A.J., Marshall, B.C., Diaz, J.L., Hasegawa, T., Samuelson, W., Povia, D., Kennedy, T.P., Piantodosi, C.A. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  6. Enhancement of the dimethylnitrosamine acute effects in rat liver by prior treatment with triton WR-1339. Díaz Gómez, M.I., Godoy, H.M., Marzi, A., de Ferreyra, E.C., de Fenos, O.M., Castro, J.A. J. Natl. Cancer Inst. (1981) [Pubmed]
  7. Triton WR-1339, a lysosomotropic compound, is excreted into bile and alters the biliary excretion of lysosomal enzymes and lipids. LaRusso, N.F., Kost, L.J., Carter, J.A., Barham, S.S. Hepatology (1982) [Pubmed]
  8. Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339. Goldstein, J.L., Brunschede, G.Y., Brown, M.S. J. Biol. Chem. (1975) [Pubmed]
  9. Commercial versus native surfactants. Surface activity, molecular components, and the effect of calcium. Bernhard, W., Mottaghian, J., Gebert, A., Rau, G.A., von Der HARDT, H., Poets, C.F. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  10. Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability. Oakes, N.D., Thalén, P.G., Jacinto, S.M., Ljung, B. Diabetes (2001) [Pubmed]
  11. Influence of ICRF 159 and trition WR 1339 on metastases of a rat epithelioma. Pimm, M.V., Baldwin, R.W. Br. J. Cancer (1975) [Pubmed]
  12. Administration of Triton WR 1339 aggravates chronic aminonucleoside nephrosis. Obara, K., Saito, T., Shoji, Y., Chiba, S., Soma, J., Sato, H., Yoshinaga, K. Nephron (1992) [Pubmed]
  13. Effects of mucokinetic drugs on rheological properties of reconstituted human nasal mucus. Rhee, C.S., Majima, Y., Cho, J.S., Arima, S., Min, Y.G., Sakakura, Y. Arch. Otolaryngol. Head Neck Surg. (1999) [Pubmed]
  14. Reduction of carbohydrate-induced hypertriglyceridemia in (fa,fa) "Zucker" rats by the alpha-glucosidase inhibitor acarbose (BAY g 5421). Krause, H.P., Keup, U., Thomas, G., Puls, W. Metab. Clin. Exp. (1982) [Pubmed]
  15. Comparison of exogenous surfactants in the treatment of wood smoke inhalation. Nieman, G.F., Paskanik, A.M., Fluck, R.R., Clark, W.R. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  16. Formation of triton WR 1339-filled rat liver lysosomes. II. Involvement of autophagy and of pre-existing lysosomes. Plattner, H., Henning, R., Brauser, B. Exp. Cell Res. (1975) [Pubmed]
  17. Interaction of liposomal and polycationic transfection complexes with pulmonary surfactant. Ernst, N., Ulrichskötter, S., Schmalix, W.A., Rädler, J., Galneder, R., Mayer, E., Gersting, S., Plank, C., Reinhardt, D., Rosenecker, J. The journal of gene medicine. (1999) [Pubmed]
  18. 9-Chloro-2,3-dihydro-5H-1,4-dioxepino(6,5-b)benzofuran, a novel antilipidemic agent structurally related to clofibrate. Witiak, D.T., Poochikian, G.K., Feller, D.R., Kenfield, N.A., Newman, H.A. J. Med. Chem. (1975) [Pubmed]
  19. Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion. Joles, J.A., Bijleveld, C., van Tol, A., Geelen, M.J., Koomans, H.A. Kidney Int. (1995) [Pubmed]
  20. Subcellular localization of acyl coenzyme A: dihydroxyacetone phosphate acyltransferase in rat liver peroxisomes (microbodies). Hajra, A.K., Burke, C.L., Jones, C.L. J. Biol. Chem. (1979) [Pubmed]
  21. Characterization of exosurf (surfactant)-mediated suppression of stimulated human alveolar macrophage cytokine responses. Thomassen, M.J., Antal, J.M., Connors, M.J., Meeker, D.P., Wiedemann, H.P. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  22. Surfactant suppresses NF-kappa B activation in human monocytic cells. Antal, J.M., Divis, L.T., Erzurum, S.C., Wiedemann, H.P., Thomassen, M.J. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  23. Host-parasite interactions with peritoneal macrophages of mice and rats in vitro and in vivo. Wagner, W.H. Infect. Immun. (1975) [Pubmed]
  24. Triacylglycerol accumulation and secretion in hepatocyte cultures. Effects of insulin, albumin and Triton WR 1339. Emmison, N., Zammit, V.A., Agius, L. Biochem. J. (1992) [Pubmed]
  25. Synthetic surfactant (Exosurf) inhibits endotoxin-stimulated cytokine secretion by human alveolar macrophages. Thomassen, M.J., Meeker, D.P., Antal, J.M., Connors, M.J., Wiedemann, H.P. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  26. Omega-3 triglycerides modify blood clearance and tissue targeting pathways of lipid emulsions. Qi, K., Seo, T., Al-Haideri, M., Worgall, T.S., Vogel, T., Carpentier, Y.A., Deckelbaum, R.J. Biochemistry (2002) [Pubmed]
  27. Synthesis and antilipidemic properties of cis-7-chloro-3a, 8b-dihydro-3a-methylfuro[3,4-b]benzofuran-3(1H)-one, a tricyclic clofibrate related lactone having a structural resemblance to mevalonolactone. Witiak, D.T., Kuwano, E., Feller, D.R., Baldwin, J.R., Newman, H.A., Sankrappa, S.K. J. Med. Chem. (1976) [Pubmed]
  28. Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production. Chirieac, D.V., Chirieac, L.R., Corsetti, J.P., Cianci, J., Sparks, C.E., Sparks, J.D. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  29. Tyloxapol attenuates the pathologic effects of endotoxin in rabbits and mortality following cecal ligation and puncture in rats by blockade of endotoxin receptor-ligand interactions. Serikov, V.B., Glazanova, T.V., Jerome, E.H., Fleming, N.W., Higashimori, H., Staub, N.C. Inflammation (2003) [Pubmed]
  30. Involvement of IL-6 and IL-6 receptor in fibrinogen synthesis in the liver of Triton WR-1339-induced hyperlipidemic rats. Ohta, S., Okazaki, M., Maruyama, M., Oguchi, K. In Vivo (2004) [Pubmed]
  31. Internalization of cytoplasmic protein by hepatic lysosomes in basal and deprivation-induced proteolytic states. Mortimore, G.E., Ward, W.F. J. Biol. Chem. (1981) [Pubmed]
  32. Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver. Butor, C., Higa, H.H., Varki, A. J. Biol. Chem. (1993) [Pubmed]
  33. The inhibition in vivo of lipoprotein lipase (clearing-factor lipase) activity by triton WR-1339. Borensztajn, J., Rone, M.S., Kotlar, T.J. Biochem. J. (1976) [Pubmed]
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