Chemical Compound Review:
CHEMBL8823 (1S,2R,3S)-1- benzo[1,3]dioxol-5-yl-3-[2...
Synonyms:
SureCN1028671, CHEBI:104763, LS-81624, SB-209670, PDSP2_001717, ...
- Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts. Shennib, H., Lee, A.G., Kuang, J.Q., Yanagisawa, M., Ohlstein, E.H., Giaid, A. Am. J. Respir. Crit. Care Med. (1998)
- Antihypertensive actions of the novel nonpeptide endothelin receptor antagonist SB 209670. Douglas, S.A., Gellai, M., Ezekiel, M., Feuerstein, G.Z., Elliott, J.D., Ohlstein, E.H. Hypertension (1995)
- Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Forbes, J.M., Leaker, B., Hewitson, T.D., Becker, G.J., Jones, C.L. Kidney Int. (1999)
- Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism. Wang, A., Holcslaw, T., Bashore, T.M., Freed, M.I., Miller, D., Rudnick, M.R., Szerlip, H., Thames, M.D., Davidson, C.J., Shusterman, N., Schwab, S.J. Kidney Int. (2000)
- SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Ohlstein, E.H., Nambi, P., Douglas, S.A., Edwards, R.M., Gellai, M., Lago, A., Leber, J.D., Cousins, R.D., Gao, A., Frazee, J.S. Proc. Natl. Acad. Sci. U.S.A. (1994)
- A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. Douglas, S.A., Louden, C., Vickery-Clark, L.M., Storer, B.L., Hart, T., Feuerstein, G.Z., Elliott, J.D., Ohlstein, E.H. Circ. Res. (1994)
- Endothelin receptor subtype distribution predisposes coronary arteries to damage. Louden, C.S., Nambi, P., Pullen, M.A., Thomas, R.A., Tierney, L.A., Solleveld, H.A., Schwartz, L.W. Am. J. Pathol. (2000)
- Pharmacokinetics and pharmacodynamics of SB 209670, an endothelin receptor antagonist: effects on the regulation of renal vascular tone. Freed, M.I., Wilson, D.E., Thompson, K.A., Harris, R.Z., Ilson, B.E., Jorkasky, D.K. Clin. Pharmacol. Ther. (1999)
- Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. Raval, P., Bingham, S., Aiyar, N., Elliott, J.D., Hunter, A.J., Ohlstein, E.H., Parsons, A.A. Br. J. Pharmacol. (1999)
- Mixed endothelin receptor antagonist, SB209670, decreases portal pressure in biliary cirrhotic rats in vivo by reducing portal venous system resistance. Kojima, H., Yamao, J., Tsujimoto, T., Uemura, M., Takaya, A., Fukui, H. J. Hepatol. (2000)
- Endothelin receptor antagonists inhibit antigen-induced lung inflammation in mice. Fujitani, Y., Trifilieff, A., Tsuyuki, S., Coyle, A.J., Bertrand, C. Am. J. Respir. Crit. Care Med. (1997)
- Comparison of endothelin B (ETB) receptors in rabbit isolated pulmonary artery and bronchus. Hay, D.W., Luttmann, M.A., Beck, G., Ohlstein, E.H. Br. J. Pharmacol. (1996)
- SB209670, a potent endothelin receptor antagonist, prevents or delays axonal degeneration after spinal cord injury. Uesugi, M., Kasuya, Y., Hayashi, K., Goto, K. Brain Res. (1998)
- Effect of endothelin antagonists on the renal haemodynamic and tubular responses to ischaemia-reperfusion injury in anaesthetised rats. Ajis, A., Bagnall, N.M., Collis, M.G., Johns, E.J. Exp. Physiol. (2003)
- Developmental toxicity and toxicokinetics of two endothelin receptor antagonists in rats and rabbits. Treinen, K.A., Louden, C., Dennis, M.J., Wier, P.J. Teratology (1999)
- Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity. Webb, M.L., Patel, P.S., Rose, P.M., Liu, E.C., Stein, P.D., Barrish, J., Lach, D.A., Stouch, T., Fisher, S.M., Hadjilambris, O., Lee, H., Skwish, S., Dickinson, K.E., Krystek, S.R. Biochemistry (1996)
- Endothelin-1 and the periaqueductal gray area of the rat: an autoradiographic and functional pharmacological study. D'Amico, M., Dashwood, M.R., Warner, T.D. Br. J. Pharmacol. (1996)
- Influence of CGRP (8-37), but not adrenomedullin (22-52), on the haemodynamic responses to lipopolysaccharide in conscious rats. Gardiner, S.M., March, J.E., Kemp, P.A., Bennett, T. Br. J. Pharmacol. (1999)
- Haemodynamic effects of losartan and the endothelin antagonist, SB 209670, in conscious, transgenic ((mRen-2)27), hypertensive rats. Gardiner, S.M., March, J.E., Kemp, P.A., Mullins, J.J., Bennett, T. Br. J. Pharmacol. (1995)
- Cardiovascular effects of endothelin-1 and endothelin antagonists in conscious, hypertensive ((mRen-2)27) rats. Gardiner, S.M., March, J.E., Kemp, P.A., Bennett, T. Br. J. Pharmacol. (2000)
- Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Ruetten, H., Thiemermann, C., Vane, J.R. Br. J. Pharmacol. (1996)
- Augmented contraction of the human isolated coronary artery by sumatriptan: a possible role for endogenous thromboxane. Maassen VanDenBrink, A., Bax, W.A., Ferrari, M.D., Zijlstra, F.J., Bos, E., Saxena, P.R. Br. J. Pharmacol. (1996)
- Nonpeptide endothelin receptor antagonists. II. Pharmacological characterization of SB 209670. Ohlstein, E.H., Beck, G.R., Douglas, S.A., Nambi, P., Lago, M.A., Gleason, J.G., Ruffolo, R.R., Feuerstein, G., Elliott, J.D. J. Pharmacol. Exp. Ther. (1994)
- Blockade of endothelin receptors reduces diet-induced hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice. Iwasa, S., Fan, J., Miyauchi, T., Watanabe, T. Pathobiology (2001)
- Role of endothelin in mediating the attenuated renal hemodynamics in Dahl salt-sensitive hypertension. Kassab, S., Novak, J., Miller, T., Kirchner, K., Granger, J. Hypertension (1997)
- Endothelin receptor antagonist improves pulmonary hemodynamics during lung ischemia/reperfusion injury. Shennib, H., Kuang, J.Q., Ohlstein, E.H., Giaid, A. Transplantation (1998)