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Chemical Compound Review

CHEBI:52330     2-aminoethoxy-(2,3- dihydroxypropoxy)phosph...

Synonyms: ANW-60230, AC1L3XGM, CTK8B8370, AKOS016003224, AK101385, ...
 
 
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Disease relevance of Glycerylphosphorylethanolamine

 

High impact information on Glycerylphosphorylethanolamine

 

Chemical compound and disease context of Glycerylphosphorylethanolamine

 

Biological context of Glycerylphosphorylethanolamine

 

Anatomical context of Glycerylphosphorylethanolamine

 

Associations of Glycerylphosphorylethanolamine with other chemical compounds

 

Gene context of Glycerylphosphorylethanolamine

  • Fast atom bombardment ionization with tandem mass spectrometry of both positive and negative ions is a useful technique for the identification of intact glycerophosphoethanolamine (GPE) phospholipids, providing information as to polar head group and fatty acyl substituents [18].
  • Such species contribute the majority of the ESI/MS negative ion current from rat and human islet glycerophosphoethanolamine (GPE), and the fraction of GPE negative ion current contributed by plasmenylethanolamine species in rat islets is higher than that for rat liver or heart and similar to that for brain [19].
  • The suggested mechanisms are supported by the tandem mass spectra of various deuterated analogs and source CAD of GPE followed by CAD tandem mass spectrometry [26].
  • GPC and GPE acted as competitive inhibitors of lysophospholipase activity, but failed to alter the activity of the other enzymes tested [16].
  • Several lysophospholipids, notably 1-acyl glycerophosphocholine (1-acyl GPC), 1-alkenyl GPC and 1-alkenyl GPE (1-alkenyl glycerophosphoethanolamine) inhibited the transacylation of 1-alkyl GPC [27].
 

Analytical, diagnostic and therapeutic context of Glycerylphosphorylethanolamine

  • However upon hypothermic reperfusion, concentrations of GPC and GPE reduced, indicating a degree of cellular damage caused by reperfusion [28].
  • The fraction of GPE lipids comprised of plasmenylethanolamine species with polyunsaturated sn-2 substituents in early-passage INS-1 cells is similar to that of islets, but declines on serial passage [29].

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