The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Arsysodila     sodium (methyl-oxido-arsoryl)methane

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cacodylic acid


High impact information on cacodylic acid

  • One of them, grown from 30 mM sodium cacodylate buffer (pH 6 to 7) and 30% 2-methyl-2,4-pentanediol with 20 mg/ml of protein, diffracts well to 2 A resolution [4].
  • In a 10 mM sodium cacodylate, 0.2 mM disodium EDTA (pH 7) buffer, we have shown the following significant results [5].
  • The catalytic core domain with the F185H mutation has been crystallized without sodium cacodylate in a new crystal form, free and complexed with the catalytic metal Mg2+ [6].
  • The base-sequence selectivity of the noncovalent binding of (+/-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyr ene (BPDE) to a series of synthetic polynucleotides in aqueous solutions (5 mM sodium cacodylate buffer, 20 mM NaCl, pH 7.0, 22 degrees C) was investigated [7].
  • The apparent length increase of sonicated calf thymus DNA (150 +/- 20 base pairs) in 2.5 mM sodium cacodylate buffer (pH 7) at 12 degrees C was determined to be 0.40 +/- 0.02 nm/bound drug) [8].

Biological context of cacodylic acid

  • In the presence of native DNA the hydrolysis of benzo[a]pyrene-7,8-diol 9,10-epoxide (BPDE) to tetrols (BPT) is markedly accelerated (by a factor of up to approximately 80 at 25 degrees C, pH 7.0, in 5 mM sodium cacodylate buffer solution) [9].

Anatomical context of cacodylic acid


Associations of cacodylic acid with other chemical compounds


Gene context of cacodylic acid


Analytical, diagnostic and therapeutic context of cacodylic acid


  1. X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform. Chen, Z., Yan, Y., Munshi, S., Li, Y., Zugay-Murphy, J., Xu, B., Witmer, M., Felock, P., Wolfe, A., Sardana, V., Emini, E.A., Hazuda, D., Kuo, L.C. J. Mol. Biol. (2000) [Pubmed]
  2. Assessment of cystine solubility in urine and of heterogeneous nucleation. Pak, C.Y., Fuller, C.J. J. Urol. (1983) [Pubmed]
  3. Salt-dependent and protein-concentration-dependent changes in the solution structure of the DNA-binding histone-like protein, HBsu, from Bacillus subtilis. Welfle, H., Misselwitz, R., Welfle, K., Groch, N., Heinemann, U. Eur. J. Biochem. (1992) [Pubmed]
  4. Crystallographic studies of snake venom proteins from Taiwan cobra (Naja nana atra). Cardiotoxin-analogue III and phospholipase A2. Wang, A.H., Yang, C.C. J. Biol. Chem. (1981) [Pubmed]
  5. Circular dichroism and UV melting studies on formation of an intramolecular triplex containing parallel T*A:T and G*G:C triplets: netropsin complexation with the triplex. Gondeau, C., Maurizot, J.C., Durand, M. Nucleic Acids Res. (1998) [Pubmed]
  6. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. Maignan, S., Guilloteau, J.P., Zhou-Liu, Q., Clément-Mella, C., Mikol, V. J. Mol. Biol. (1998) [Pubmed]
  7. Base-sequence dependence of noncovalent complex formation and reactivity of benzo[a]pyrene diol epoxide with polynucleotides. Geacintov, N.E., Shahbaz, M., Ibanez, V., Moussaoui, K., Harvey, R.G. Biochemistry (1988) [Pubmed]
  8. Studies on interaction of anthracycline antibiotics and deoxyribonucleic acid: geometry of intercalation of iremycin and daunomycin. Fritzsche, H., Triebel, H., Chaires, J.B., Dattagupta, N., Crothers, D.M. Biochemistry (1982) [Pubmed]
  9. Noncovalent binding of 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxytetrahydrobenzo[a]pyrene to deoxyribonucleic acid and its catalytic effect on the hydrolysis of the diol epoxide to tetrol. Geacintov, N.E., Yoshida, H., Ibanez, V., Harvey, R.G. Biochemistry (1982) [Pubmed]
  10. Intercellular spaces in chemically fixed corneal endothelia are related to solute pump activity not to solvent coupling. Hodson, S., Mayes, K.R. J. Physiol. (Lond.) (1979) [Pubmed]
  11. Immunocytochemical study of amelogenin deposition during the early odontogenesis of molars in alendronate-treated newborn rats. Massa, L.F., Bradaschia-Correa, V., Arana-Chavez, V.E. J. Histochem. Cytochem. (2006) [Pubmed]
  12. Cyclophosphamide-induced changes in rodent odontogenesis. A light- and electron-microscopic study. Orams, H.J. Cell Tissue Res. (1983) [Pubmed]
  13. The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Müller, L.J., Pels, E., Vrensen, G.F. The British journal of ophthalmology. (2001) [Pubmed]
  14. A comparative study of EM fixation procedures for the adult rat spinal cord based on regional blood flow. Hill, P.K., de la Torre, J.C., Thompson, S.M., Bullock, D.F., Rosenfield-Wessells, S. J. Neurosci. Methods (1982) [Pubmed]
  15. Common structural features of different viroids: serial arrangement of double helical sections and internal loops. Langowski, J., Henco, K., Riesner, D., Sänger, H.L. Nucleic Acids Res. (1978) [Pubmed]
  16. Crystallization and preliminary X-ray diffraction analysis of a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Chu, G.C., Park, S.Y., Shiro, Y., Yoshida, T., Ikeda-Saito, M. J. Struct. Biol. (1999) [Pubmed]
  17. Modifications of S100-protein immunoreactivity in rat brain induced by tissue preparation. Rickmann, M., Wolff, J.R. Histochem. Cell Biol. (1995) [Pubmed]
  18. Rapid primary microwave-osmium fixation. I. Preservation of structure for electron microscopy in seconds. Login, G.R., Dwyer, B.K., Dvorak, A.M. J. Histochem. Cytochem. (1990) [Pubmed]
  19. Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant enzyme and preliminary X-ray studies. Fernández-Murga, M.L., Ramón-Maiques, S., Gil-Ortiz, F., Fita, I., Rubio, V. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  20. Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anion. Gailer, J., George, G.N., Harris, H.H., Pickering, I.J., Prince, R.C., Somogyi, A., Buttigieg, G.A., Glass, R.S., Denton, M.B. Inorganic chemistry. (2002) [Pubmed]
  21. Interaction of lambda cro repressor with synthetic operator OR3 studied by competition binding with minor groove binders. Gursky, G.V., Surovaya, A.N., Kurochkin, A.V., Chernov, B.K., Volkov, S.K., Kirpichnikov, M.P. J. Biomol. Struct. Dyn. (1992) [Pubmed]
  22. An easy method for the removal of Epon resin from semi-thin sections. Application of the avidin-biotin technique. Vidal, S., Lombardero, M., Sánchez, P., Román, A., Moya, L. Histochem. J. (1995) [Pubmed]
  23. Localization of carbohydrate and DNA in cyst-like structures from a human intestinal spirochaete. Barber, P.M., Lewis, G.M., Barrett, S.P. Anaerobe (1995) [Pubmed]
  24. Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. Henkels, C.H., Kurz, J.C., Fierke, C.A., Oas, T.G. Biochemistry (2001) [Pubmed]
  25. The promotion of self-association of horse-heart cytochrome c by hexametaphosphate anions. Whitford, D., Concar, D.W., Williams, R.J. Eur. J. Biochem. (1991) [Pubmed]
  26. The natural history of intimal flaps caused by angioscopy. Hsiang, Y.N., Fragoso, M., Lundkist, A., Weis, M. Annals of vascular surgery. (1992) [Pubmed]
  27. Ultrastructural characterization of internal basement membrane of junctional epithelium at dentogingival border. Sawada, T., Inoue, S. Anat. Rec. (1996) [Pubmed]
WikiGenes - Universities