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MeSH Review

Life Change Events

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Disease relevance of Life Change Events


Psychiatry related information on Life Change Events


High impact information on Life Change Events


Chemical compound and disease context of Life Change Events


Biological context of Life Change Events

  • Effects were assessed by measuring salivary cortisol production at baseline and in response to two potentially stressful events, a heel-stick blood draw and a physical exam, in infants born at 33-34 weeks gestation [20].
  • It is concluded that the delayed response to formalin injection is the result of complex interactions involving peripheral mechanisms and central neuronal plasticity in which activity initiated by a noxious input persists after the cessation of the input as a consequence of a stressful event such as the cold-water swim [21].
  • This is consistent with the idea that birds breeding in extreme environments with short breeding seasons may exhibit a decreased adrenocortical response to stressful events to prevent high corticosterone concentrations from inducing interruptions of reproductive behavior [22].
  • In response to a stressful event, the stimulation of the corticotropin-releasing hormone (CRH) system is probably involved in the observed modifications of body temperature and colonic motility [23].
  • The data now available indicate that labour and lactation, or the occurrence of a stressful event such as the very first jump with a parachute causes in NGF plasma levels as well as changes in the distribution of NGF receptors on lymphocytes [24].

Anatomical context of Life Change Events


Gene context of Life Change Events

  • We hypothesized that CRF might mediate some of the effects of cocaine and as such it may be a link between stressful events and increased vulnerability to cocaine addiction [30].
  • Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event [25].
  • We conclude that the interaction between CRH and MR presents a novel mechanism involved in the adaptation of the brain to psychologically stressful events [31].
  • OBJECTIVES: The objective was to examine the prevalence of psychological distress in patients hospitalized for an acute exacerbation COPD, assess how they appraise and cope with the recent stressful event, and examine the relationships among coping, appraisal, and psychological distress [32].
  • INTERVENTION: Patients were assigned to write either about the most stressful event of their lives (n = 71; 39 asthma, 32 rheumatoid arthritis) or about emotionally neutral topics (n = 41; 22 asthma, 19 rheumatoid arthritis) (the control intervention) [12].

Analytical, diagnostic and therapeutic context of Life Change Events


  1. Cardiovascular risk factors in outpatients with bipolar disorder. Klumpers, U.M., Boom, K., Janssen, F.M., Tulen, J.H., Loonen, A.J. Pharmacopsychiatry (2004) [Pubmed]
  2. TNF-alpha and psychologically stressful events in healthy subjects: potential relevance for multiple sclerosis relapse. Lalive, P.H., Burkhard, P.R., Chofflon, M. Behav. Neurosci. (2002) [Pubmed]
  3. Quality of life and social environment as reported by Chinese immigrants with non-insulin-dependent diabetes mellitus. Rankin, S.H., Galbraith, M.E., Huang, P. The Diabetes educator. (1997) [Pubmed]
  4. Cerebral blood flow and energy metabolism during stress. Bryan, R.M. Am. J. Physiol. (1990) [Pubmed]
  5. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Sharkey, S.W., Lesser, J.R., Zenovich, A.G., Maron, M.S., Lindberg, J., Longe, T.F., Maron, B.J. Circulation (2005) [Pubmed]
  6. Adolescent suicide, depression and family dysfunction. Martin, G., Rozanes, P., Pearce, C., Allison, S. Acta psychiatrica Scandinavica. (1995) [Pubmed]
  7. Experiential and hormonal correlates of maternal behavior in teen and adult mothers. Krpan, K.M., Coombs, R., Zinga, D., Steiner, M., Fleming, A.S. Hormones and behavior. (2005) [Pubmed]
  8. Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies. Tanaka, M., Yoshida, M., Emoto, H., Ishii, H. Eur. J. Pharmacol. (2000) [Pubmed]
  9. Plasma testosterone levels in patients with combat-related posttraumatic stress disorder. Spivak, B., Maayan, R., Mester, R., Weizman, A. Neuropsychobiology (2003) [Pubmed]
  10. Accumbens GABA-ergic innervation contributes to the stressor-induced locomotor depression in rats. Płaźnik, A., Stefański, R., Pałejko, W., Kostowski, W. Polish journal of pharmacology and pharmacy. (1992) [Pubmed]
  11. Brain corticosteroid receptor balance in health and disease. De Kloet, E.R., Vreugdenhil, E., Oitzl, M.S., Joëls, M. Endocr. Rev. (1998) [Pubmed]
  12. Effects of writing about stressful experiences on symptom reduction in patients with asthma or rheumatoid arthritis: a randomized trial. Smyth, J.M., Stone, A.A., Hurewitz, A., Kaell, A. JAMA (1999) [Pubmed]
  13. Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Donahue, C.P., Kosik, K.S., Shors, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  14. Severe hypovitaminosis C occurring as the result of adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. Marcus, S.L., Dutcher, J.P., Paietta, E., Ciobanu, N., Strauman, J., Wiernik, P.H., Hutner, S.H., Frank, O., Baker, H. Cancer Res. (1987) [Pubmed]
  15. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. Guo, Y., Guettouche, T., Fenna, M., Boellmann, F., Pratt, W.B., Toft, D.O., Smith, D.F., Voellmy, R. J. Biol. Chem. (2001) [Pubmed]
  16. Effect of physical stress on sensitivity of lymphocytes to inhibition by prostaglandin E2. Goodwin, J.S., Bromberg, S., Staszak, C., Kaszubowski, P.A., Messner, R.P., Neal, J.F. J. Immunol. (1981) [Pubmed]
  17. Increased sensitivity to stress in spontaneous recurrence of methamphetamine psychosis: noradrenergic hyperactivity with contribution from dopaminergic hyperactivity. Yui, K., Goto, K., Ikemoto, S., Ishiguro, T., Kamata, Y. Journal of clinical psychopharmacology. (2000) [Pubmed]
  18. Brain polyamine stress response: recurrence after repetitive stressor and inhibition by lithium. Gilad, G.M., Gilad, V.H. J. Neurochem. (1996) [Pubmed]
  19. High and low emotion events influence emotional stress perceptions and are associated with salivary cortisol response changes in a consecutive stress paradigm. Nejtek, V.A. Psychoneuroendocrinology (2002) [Pubmed]
  20. Effects of prenatal betamethasone exposure on regulation of stress physiology in healthy premature infants. Davis, E.P., Townsend, E.L., Gunnar, M.R., Georgieff, M.K., Guiang, S.F., Ciffuentes, R.F., Lussky, R.C. Psychoneuroendocrinology (2004) [Pubmed]
  21. Delayed nociceptive response following cold-water swim in the formalin test: possible mechanisms of action. Fuchs, P.N., Kerr, B., Melzack, R. Exp. Neurol. (1996) [Pubmed]
  22. Baseline and stress-induced levels of corticosterone during different life cycle substages in a shorebird on the high arctic breeding grounds. Reneerkens, J., Morrison, R.I., Ramenofsky, M., Piersma, T., Wingfield, J.C. Physiol. Biochem. Zool. (2002) [Pubmed]
  23. Effects of etifoxine on stress-induced hyperthermia, freezing behavior and colonic motor activation in rats. Verleye, M., Gillardin, J.M. Physiol. Behav. (2004) [Pubmed]
  24. NGF regulatory role in stress and coping of rodents and humans. Alleva, E., Petruzzi, S., Cirulli, F., Aloe, L. Pharmacol. Biochem. Behav. (1996) [Pubmed]
  25. Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event. Kas, M.J., Bruijnzeel, A.W., Haanstra, J.R., Wiegant, V.M., Adan, R.A. J. Mol. Endocrinol. (2005) [Pubmed]
  26. Inescapable stress enhances extracellular acetylcholine in the rat hippocampus and prefrontal cortex but not the nucleus accumbens or amygdala. Mark, G.P., Rada, P.V., Shors, T.J. Neuroscience (1996) [Pubmed]
  27. Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response. Bilang-Bleuel, A., Ulbricht, S., Chandramohan, Y., De Carli, S., Droste, S.K., Reul, J.M. Eur. J. Neurosci. (2005) [Pubmed]
  28. High levels of human chromogranin A in umbilical cord plasma and amniotic fluid at parturition. Florio, P., Mezzesimi, A., Turchetti, V., Severi, F.M., Ticconi, C., Forconi, S., Petraglia, F. J. Soc. Gynecol. Investig. (2002) [Pubmed]
  29. Adrenocortical activity and emotion regulation. Stansbury, K., Gunnar, M.R. Monographs of the Society for Research in Child Development. (1994) [Pubmed]
  30. Neurobiology of stress and cocaine addiction. Studies on corticotropin-releasing factor in rats, monkeys, and humans. Sarnyai, Z. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  31. Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone. Gesing, A., Bilang-Bleuel, A., Droste, S.K., Linthorst, A.C., Holsboer, F., Reul, J.M. J. Neurosci. (2001) [Pubmed]
  32. Coping and psychological distress in hospitalized patients with chronic obstructive pulmonary disease. Andenaes, R., Kalfoss, M.H., Wahl, A.K. Heart & lung : the journal of critical care. (2006) [Pubmed]
  33. Esmolol and the adrenergic response to perioperative stimuli. Murthy, V.S., Hwang, T.F., Sandage, B.W., Laddu, A.R. Journal of clinical pharmacology. (1986) [Pubmed]
  34. Parental experience of family stress during hematopoietic stem cell transplantation of pediatric patients in germ-free isolation in Taiwan. Wu, J., Mu, P.F., Tsay, S.L., Chiou, T.J. Cancer nursing. (2005) [Pubmed]
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