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Chemical Compound Review

clobenpropit     N'-[(4-chlorophenyl)methyl]- 1-[3-(3H...

Synonyms: Tocris-0752, CHEMBL14690, SureCN49050, Vuf-9153, SureCN8312286, ...
 
 
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Disease relevance of Vuf-9153

 

Psychiatry related information on Vuf-9153

  • A bilateral intrahippocampal (i.h.) injection of clobenpropit (5, 10 microg per site, dose-dependent) markedly improved the working and reference memory deficits induced by MK-801 [5].
 

High impact information on Vuf-9153

 

Chemical compound and disease context of Vuf-9153

 

Biological context of Vuf-9153

 

Anatomical context of Vuf-9153

 

Associations of Vuf-9153 with other chemical compounds

 

Gene context of Vuf-9153

References

  1. Pre-synaptic histamine H(3) receptors regulate glutamate, but not GABA release in rat thalamus. Garduño-Torres, B., Treviño, M., Gutiérrez, R., Arias-Montaño, J.A. Neuropharmacology (2007) [Pubmed]
  2. Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats. Zhang, L., Chen, Z., Ren, K., Leurs, R., Chen, J., Zhang, W., Ye, B., Wei, E., Timmerman, H. Eur. J. Pharmacol. (2003) [Pubmed]
  3. Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. Fischer, W., van der Goot, H. Journal of neural transmission (Vienna, Austria : 1996) (1998) [Pubmed]
  4. Histamine H3 receptors modulate reactive hyperemia in rat gut. Pawlik, W.W., Obuchowicz, R., Pawlik, M.W., Sendur, R., Biernat, J., Brzozowski, T., Konturek, S.J. J. Physiol. Pharmacol. (2004) [Pubmed]
  5. Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats. Huang, Y.W., Hu, W.W., Chen, Z., Zhang, L.S., Shen, H.Q., Timmerman, H., Leurs, R., Yanai, K. Behav. Brain Res. (2004) [Pubmed]
  6. Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. Oda, T., Morikawa, N., Saito, Y., Masuho, Y., Matsumoto, S. J. Biol. Chem. (2000) [Pubmed]
  7. Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release. Munzar, P., Tanda, G., Justinova, Z., Goldberg, S.R. Neuropsychopharmacology (2004) [Pubmed]
  8. Novel histamine H(3)-receptor antagonists and partial agonists with a non-aminergic structure. Nickel, T., Bauer, U., Schlicker, E., Kathmann, M., Göthert, M., Sasse, A., Stark, H., Schunack, W. Br. J. Pharmacol. (2001) [Pubmed]
  9. Histamine H3 receptor-mediated impairment of contextual fear conditioning and in-vivo inhibition of cholinergic transmission in the rat basolateral amygdala. Passani, M.B., Cangioli, I., Baldi, E., Bucherelli, C., Mannaioni, P.F., Blandina, P. Eur. J. Neurosci. (2001) [Pubmed]
  10. Histamine H(3)-receptor antagonists inhibit gastroprotection by (R)-alpha-methylhistamine in the rat. Morini, G., Grandi, D., Stark, H., Schunack, W. Br. J. Pharmacol. (2000) [Pubmed]
  11. Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. Godlewski, G., Malinowska, B., Buczko, W., Schlicker, E. Naunyn Schmiedebergs Arch. Pharmacol. (1997) [Pubmed]
  12. Activation of histamine H3 receptors in human nasal mucosa inhibits sympathetic vasoconstriction. Varty, L.M., Gustafson, E., Laverty, M., Hey, J.A. Eur. J. Pharmacol. (2004) [Pubmed]
  13. Identification of a histamine H4 receptor on human eosinophils--role in eosinophil chemotaxis. O'Reilly, M., Alpert, R., Jenkinson, S., Gladue, R.P., Foo, S., Trim, S., Peter, B., Trevethick, M., Fidock, M. J. Recept. Signal Transduct. Res. (2002) [Pubmed]
  14. Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes. Yang, R., Hey, J.A., Aslanian, R., Rizzo, C.A. Pharmacology (2002) [Pubmed]
  15. STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes. Horr, B., Borck, H., Thurmond, R., Grösch, S., Diel, F. Int. Immunopharmacol. (2006) [Pubmed]
  16. Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Buckland, K.F., Williams, T.J., Conroy, D.M. Br. J. Pharmacol. (2003) [Pubmed]
  17. Histamine H3 receptor activation inhibits neurogenic sympathetic vasoconstriction in porcine nasal mucosa. Varty, L.M., Hey, J.A. Eur. J. Pharmacol. (2002) [Pubmed]
  18. In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application. Jansen, F.P., Mochizuki, T., Yamamoto, Y., Timmerman, H., Yamatodani, A. Eur. J. Pharmacol. (1998) [Pubmed]
  19. Effect of clobenpropit on regional cerebral blood flow in rat hippocampus. Chen, Z. Acta Pharmacol. Sin. (2001) [Pubmed]
  20. Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice. Hossen, M.A., Inoue, T., Shinmei, Y., Fujii, Y., Watanabe, T., Kamei, C. J. Pharmacol. Sci. (2006) [Pubmed]
  21. Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. Stark, H., Purand, K., Ligneau, X., Rouleau, A., Arrang, J.M., Garbarg, M., Schwartz, J.C., Schunack, W. J. Med. Chem. (1996) [Pubmed]
  22. H2 receptor-mediated facilitation and H3 receptor-mediated inhibition of noradrenaline release in the guinea-pig brain. Timm, J., Marr, I., Werthwein, S., Elz, S., Schunack, W., Schlicker, E. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
  23. An in vitro study of histamine on the pulmonary artery of the Wistar-Kyoto and spontaneously hypertensive rats. Lau, W.H., Kwan, Y.W., Au, A.L., Cheung, W.H. Eur. J. Pharmacol. (2003) [Pubmed]
  24. Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine. Hahn, A., Huber, A., Neumayer, N., Allescher, H.D. Eur. J. Pharmacol. (1998) [Pubmed]
  25. Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. Yu, Y., Kawarai, M., Koss, M.C. Eur. J. Pharmacol. (2001) [Pubmed]
  26. Effects of clobenpropit (VUF-9153), a histamine H3-receptor antagonist, on learning and memory, and on cholinergic and monoaminergic systems in mice. Miyazaki, S., Onodera, K., Imaizumi, M., Timmerman, H. Life Sci. (1997) [Pubmed]
  27. Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice. Yokoyama, H., Onodera, K., Maeyama, K., Sakurai, E., Iinuma, K., Leurs, R., Timmerman, H., Watanabe, T. Eur. J. Pharmacol. (1994) [Pubmed]
 
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