The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Alanosina     (2S)-2-amino-3-(hydroxy- nitroso...

Synonyms: Alanosine, Alanosinum, L-Alanosine, Alanosine (L), CHEMBL452715, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AI3-52867


High impact information on AI3-52867


Chemical compound and disease context of AI3-52867


Biological context of AI3-52867

  • As measured by [3H]thymidine incorporation, DNA synthesis in all seven MTAP-primary T-ALL cells was inhibited by L-alanosine with a mean IC50 of 4.8+/-5.3 ILM (range, 0.3-11.3 microM) [12].
  • In contrast, L-alanosine (adenine starvation) failed to affect DNA synthesis for at least 24 hr at a concentration that inhibits cell growth by 80% [13].
  • The saturation curve of the native enzyme for L-alanosine indicates the lack of homotropic cooperative interactions between the catalytic sites for the utilization of this compound [3].
  • In the presence of subinhibitory concentrations of alanosine, both CHO cells and the HDF show excessive sensitivity to exogenous guanine--a phenotype which closely resembles that seen with some of the mutants containing reduced enzymatic activity of ASS [14].
  • A novel synergistic effect of the antitumor agent alanosine (2-amino-3-(hydroxynitrosoamino) propionic acid), which specifically inhibits the enzyme adenylosuccinate synthetase (ASS) and guanine on the growth of Chinese hamster ovary (CHO) cells and human diploid fibroblasts (HDF) has been observed [14].

Anatomical context of AI3-52867


Associations of AI3-52867 with other chemical compounds


Gene context of AI3-52867


Analytical, diagnostic and therapeutic context of AI3-52867


  1. EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. Batova, A., Cottam, H., Yu, J., Diccianni, M.B., Carrera, C.J., Yu, A.L. Blood (2006) [Pubmed]
  2. Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas. Illei, P.B., Rusch, V.W., Zakowski, M.F., Ladanyi, M. Clin. Cancer Res. (2003) [Pubmed]
  3. L-alanosine: a noncooperative substrate for Escherichia coli aspartate transcarbamylase. Baillon, J., Tauc, P., Hervé, G. Biochemistry (1985) [Pubmed]
  4. Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study. Von Hoff, D.D., Green, S.J., Neidhart, J.A., Fabian, C., Budd, T., Boyd, J.F., Osborne, C.K. Investigational new drugs. (1991) [Pubmed]
  5. Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase. Turker, M.S., Martin, G.M. Mol. Cell. Biol. (1985) [Pubmed]
  6. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Huang, Y., Dai, Z., Barbacioru, C., Sadée, W. Cancer Res. (2005) [Pubmed]
  7. Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy. Batova, A., Diccianni, M.B., Nobori, T., Vu, T., Yu, J., Bridgeman, L., Yu, A.L. Blood (1996) [Pubmed]
  8. Presence of methylthioadenosine phosphorylase (MTAP) in hematopoietic stem/progenitor cells: its therapeutic implication for MTAP (-) malignancies. Yu, J., Batova, A., Shao, L., Carrera, C.J., Yu, A.L. Clin. Cancer Res. (1997) [Pubmed]
  9. Determinants of the toxicity of L-alanosine to various organs of the mouse. Tyagi, A.K., Thake, D.C., McGee, E., Cooney, D.A. Toxicology (1981) [Pubmed]
  10. Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells. Li, W., Su, D., Mizobuchi, H., Martin, D.S., Gu, B., Gorlick, R., Cole, P., Bertino, J.R. Oncol. Res. (2004) [Pubmed]
  11. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Chitnis, M.P., Adwankar, M.K., Amonkar, A.J. Tumori. (1984) [Pubmed]
  12. Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro. Batova, A., Diccianni, M.B., Omura-Minamisawa, M., Yu, J., Carrera, C.J., Bridgeman, L.J., Kung, F.H., Pullen, J., Amylon, M.D., Yu, A.L. Cancer Res. (1999) [Pubmed]
  13. Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells. Nguyen, B.T., El Sayed, Y.M., Sadée, W. Cancer Res. (1984) [Pubmed]
  14. A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism. Gupta, R.S. J. Cell. Physiol. (1980) [Pubmed]
  15. Involvement of purine nucleotide synthetic pathways in gonadotropin-induced meiotic maturation in mouse cumulus cell-enclosed oocytes. Downs, S.M. Mol. Reprod. Dev. (1997) [Pubmed]
  16. Biochemical effect of three different inhibitors of purine/pyrimidine metabolism on differentiation in HL60 cells. Ahmed, N., Weidemann, M.J. Leuk. Res. (1995) [Pubmed]
  17. Inhibition of mouse molar tooth germ morphogenesis in organ culture by alanosine. Dye, F.J., Kollar, E.J. Exp. Cell Biol. (1978) [Pubmed]
  18. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Marcé, S., Balagué, O., Colomo, L., Martinez, A., Höller, S., Villamor, N., Bosch, F., Ott, G., Rosenwald, A., Leoni, L., Esteller, M., Fraga, M.F., Montserrat, E., Colomer, D., Campo, E. Clin. Cancer Res. (2006) [Pubmed]
  19. T-state active site of aspartate transcarbamylase: crystal structure of the carbamyl phosphate and L-alanosine ligated enzyme. Huang, J., Lipscomb, W.N. Biochemistry (2006) [Pubmed]
  20. Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications. Powell, E.L., Leoni, L.M., Canto, M.I., Forastiere, A.A., Iocobuzio-Donahue, C.A., Wang, J.S., Maitra, A., Montgomery, E. Am. J. Surg. Pathol. (2005) [Pubmed]
  21. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Efferth, T., Gebhart, E., Ross, D.D., Sauerbrey, A. Biochem. Pharmacol. (2003) [Pubmed]
  22. Adenosine kinase as a new selective marker in somatic cell genetics: isolation of adenosine kinase--deficient mouse cell lines and human--mouse hybrid cell lines containing adenosine kinase. Chan, T.S., Creagan, R.P., Reardon, M.P. Somatic Cell Genet. (1978) [Pubmed]
  23. Synthesis and in vitro biological evaluation of N-[(5-amino-1-beta-D-ribofuranosyl-1H-imidazol-4-yl)carbonyl]-3- (hydroxynitrosamino)-L-alanine (L-alanosine AICO ribonucleoside). Strazzolini, P., Malabarba, A., Ferrari, P., Grandi, M., Cavalleri, B. J. Med. Chem. (1984) [Pubmed]
  24. Determination of L-alanosine in plasma and urine by reversed-phase high-performance liquid chromatography of the Dns derivative. Powis, G., Ames, M.M. J. Chromatogr. (1979) [Pubmed]
  25. Phase II evaluation of L-alanosine (NSC-153353) for patients with disseminated malignant melanoma. Creagan, E.T., Long, H.J., Ahmann, D.L., Green, S.J. Am. J. Clin. Oncol. (1984) [Pubmed]
  26. Metabolic anomalies in cri du chat syndrome (5p-) lymphocytes and de novo purine synthesis. Peeters, M.A., Rethoré, M.O., Aris, L., Megarbane, A., Cattaneo, F., Lejeune, J. Ann. Genet. (1991) [Pubmed]
WikiGenes - Universities