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MeSH Review

Sick Sinus Syndrome

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Disease relevance of Sick Sinus Syndrome


High impact information on Sick Sinus Syndrome


Chemical compound and disease context of Sick Sinus Syndrome


Biological context of Sick Sinus Syndrome


Anatomical context of Sick Sinus Syndrome


Gene context of Sick Sinus Syndrome

  • There was no significant difference in plasma PF4 and beta thromboglobulin between patients with complete heart block and sick sinus syndrome in the corresponding pacing mode [23].
  • The criteria of EP30 < 3.0 microV and ED4 > 22 ms as atrial early potential gave a sensitivity of 76%, a specificity of 91%, a positive predictive value of 74% and a negative predictive value of 93% for identification of patients with sick sinus syndrome [24].
  • We describe the case of a 42-year-old woman with a rare combination of congenital pericardial absence, atrial septal defect within the fossa ovalis and sick sinus syndrome [22].
  • Two patients with sick sinus syndrome were temporarily paced using APC Devices pacemaker models EC 4542 and EV 4543 respectively, which showed transient increase (53% and 83% of the preset rate, respectively) in pacing rate [25].
  • This study examined the functions of the DDD/AMC mode in 12 patients with sick sinus syndrome (SSS; n = 10) or paroxysmal complete AVB (n = 2) [26].

Analytical, diagnostic and therapeutic context of Sick Sinus Syndrome


  1. Etiology of the negative chronotropic responses to transient coronary artery occlusion in the anesthetized rhesus monkey. Alter, W.A., Hawkins, R.N., Evans, D.E. Circulation (1978) [Pubmed]
  2. Cost benefit analysis of single and dual chamber pacing for sick sinus syndrome and atrioventricular block. An economic sensitivity analysis of the literature. Sutton, R., Bourgeois, I. Eur. Heart J. (1996) [Pubmed]
  3. Repair of left atrial abnormalities in children by the superior approach. Richi, A.A., Sade, R.M., May, M.G., Hohn, A.R. Ann. Thorac. Surg. (1981) [Pubmed]
  4. Procainamide-induced sinus node dysfunction in patients with chronic renal failure. Kim, H.G., Friedman, H.S. Chest (1979) [Pubmed]
  5. Electrophysiologic effects of hydralazine on sinoatrial function in patients with sick sinus node syndrome. Engel, T.R., Leddy, C., Gonzalez, A.D., Meister, S.G., Frankl, W.S. Am. J. Cardiol. (1978) [Pubmed]
  6. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). Benson, D.W., Wang, D.W., Dyment, M., Knilans, T.K., Fish, F.A., Strieper, M.J., Rhodes, T.H., George, A.L. J. Clin. Invest. (2003) [Pubmed]
  7. Sick sinus syndrome: an adenosine-mediated disease. Watt, A.H. Lancet (1985) [Pubmed]
  8. Disopyramide. Morady, F., Scheinman, M.M., Desai, J. Ann. Intern. Med. (1982) [Pubmed]
  9. Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. Alboni, P., Menozzi, C., Brignole, M., Paparella, N., Gaggioli, G., Lolli, G., Cappato, R. Circulation (1997) [Pubmed]
  10. A randomized comparison of atrial and dual-chamber pacing in 177 consecutive patients with sick sinus syndrome: echocardiographic and clinical outcome. Nielsen, J.C., Kristensen, L., Andersen, H.R., Mortensen, P.T., Pedersen, O.L., Pedersen, A.K. J. Am. Coll. Cardiol. (2003) [Pubmed]
  11. Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome. van Wijk, L.M., van Gelder, I., Crijns, H.J., van den Toren, E.W., Lie, K.I., Rüegg, P.C. Am. J. Med. (1989) [Pubmed]
  12. Electrophysiological effects of ethmozin on sinus nodal function in patients with and without sinus node dysfunction. Rakovec, P., Jakopin, J., Rode, P., Kenda, M.F., Horvat, M. Eur. Heart J. (1984) [Pubmed]
  13. Symptomatic sick sinus syndrome due to guanethidine. Case report. Rowe, J., Bassan, M.M. Hypertension (1979) [Pubmed]
  14. Comparison of effects of propranolol versus pindolol on sinus rate and pacing frequency in sick sinus syndrome. Strickberger, S.A., Fish, R.D., Lamas, G.A., Cantillon, C., Bhatia, S., McGowan, N., Antman, E.M., Friedman, P.L. Am. J. Cardiol. (1993) [Pubmed]
  15. Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration. Keidar, S., Grenadier, E., Palant, A. Am. Heart J. (1982) [Pubmed]
  16. Usefulness of rate responsive atrial pacing in patients with sick sinus syndrome. Hatano, K., Kato, R., Hayashi, H., Noda, S., Sotobata, I., Murase, M. Pacing and clinical electrophysiology : PACE. (1989) [Pubmed]
  17. Insulin-like growth factor I receptors in human cardiac myocytes and their relation to myocardial hypertrophy. Toyozaki, T., Hiroe, M., Hasumi, M., Horie, T., Hosoda, S., Tsushima, T., Sekiguchi, M. Jpn. Circ. J. (1993) [Pubmed]
  18. Outcome of total hip replacement for avascular necrosis in systemic lupus erythematosus. Zangger, P., Gladman, D.D., Urowitz, M.B., Bogoch, E.R. J. Rheumatol. (2000) [Pubmed]
  19. Sick sinus syndrome requiring permanent pacemaker implantation in a patient with mirror-image dextrocardia. Goyal, S.L., Lichestein, E., Gupta, P.K., Chadda, K.D., Lajam, F. Chest (1976) [Pubmed]
  20. Value of physical and pharmacological tests in predicting intrinsic and extrinsic sick sinus syndrome. Bhandari, S., Talwar, K.K., Kaul, U., Bhatia, M.L. International journal of cardiology. (1986) [Pubmed]
  21. Endocardial biventricular pacing. Jaïs, P., Douard, H., Shah, D.C., Barold, S., Barat, J.L., Clémenty, J. Pacing and clinical electrophysiology : PACE. (1998) [Pubmed]
  22. Congenital absence of the pericardium associated with atrial septal defect and sick sinus syndrome. Chiariello, M., Indolfi, C., Condorelli, M. International journal of cardiology. (1984) [Pubmed]
  23. Effects of atrioventricular asynchrony on platelet activation: implication of thromboembolism in paced patients. Lau, C.P., Tse, H.F., Cheng, G. Heart (1997) [Pubmed]
  24. Detection of patients with sick sinus syndrome by use of low amplitude potentials early in filtered P wave. Yamada, T., Fukunami, M., Kumagai, K., Abe, Y., Kim, J., Sanada, S., Hori, M., Kamada, T., Hoki, N. J. Am. Coll. Cardiol. (1996) [Pubmed]
  25. Devices external pulse generator: a reliable temporary pacemaker? Inoue, D., Ochiai, M., Katsume, H., Ijichi, H. Clinical cardiology. (1987) [Pubmed]
  26. Use of automatic mode change between DDD and AAI to facilitate native atrioventricular conduction in patients with sick sinus syndrome or transient atrioventricular block. Mayumi, H., Kohno, H., Yasui, H., Kawachi, Y., Tokunaga, K. Pacing and clinical electrophysiology : PACE. (1996) [Pubmed]
  27. Intravenous adenosine: a noninvasive diagnostic test for sick sinus syndrome. Resh, W., Feuer, J., Wesley, R.C. Pacing and clinical electrophysiology : PACE. (1992) [Pubmed]
  28. Uncommon presentation of pheochromocytoma: case studies. Grossman, E., Knecht, A., Holtzman, E., Nussinovich, N., Rosenthal, T. Angiology. (1985) [Pubmed]
  29. Benefits of dual chamber pacing in sick sinus syndrome. Mitsuoka, T., Kenny, R.A., Yeung, T.A., Chan, S.L., Perrins, J.E., Sutton, R. British heart journal. (1988) [Pubmed]
  30. Significant myocardial pathology and increase of alpha 1-adrenergic receptor number affecting the arrhythmogenic condition in cases with ventricular tachycardia. Hasumi, M., Hiroe, M., Fujita, N., Hasumi, S., Toyosaki, T., Nagao, H., Hosoda, S., Kasajima, T., Sekiguchi, M. Heart and vessels. Supplement. (1990) [Pubmed]
  31. Intravenous injection of adenosine triphosphate for assessing sinus node dysfunction in patients with sick sinus syndrome. Saito, D., Yamanari, H., Matsubara, K., Maekawa, K., Mizuo, K., Sato, T., Kobayashi, H., Morita, H., Haraoka, S. Arzneimittel-Forschung. (1993) [Pubmed]
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