Disease relevance of Sick Sinus Syndrome

• We suggest that (1) rhesus monkeys may be suitable for study of the sick sinus syndrome, and (2) atropine-resistant bradycardia and atrial arrhythmias observed in postinfarction patients may be due to sinus node artery blockade [1].
• The difference in 10 year cumulative cost between VVI and DDD is 13 times the purchase price of a VVI pulse generator for sick sinus syndrome and 7 times for atrioventricular block [2].
• Though a few transient arrhythmias were seen, all survivors are in sinus rhythm without evidence of sick sinus syndrome, except 1 patient in whom atrial flutter associated with cardiomyopathy developed 1 year after operation [3].
• Thus, procainamide may produce electrophysiologic features of "sick sinus syndrome" in patients with chronic renal failure even when blood levels of this substance are being monitored [4].
• Hydralazine merits clinical trial for treatment of sick sinus syndrome with concomitant hypertension [5].

High impact information on Sick Sinus Syndrome

• Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A) [6].
• Sick sinus syndrome: an adenosine-mediated disease [7].
• Disopyramide has the potential to suppress sinus node function and, therefore, must be used cautiously in patients with the sick sinus syndrome [8].
• Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial [9].
• OBJECTIVES: A randomized trial was done to compare single-chamber atrial (AAI) and dual-chamber (DDD) pacing in patients with sick sinus syndrome (SSS) [10].

Chemical compound and disease context of Sick Sinus Syndrome

• Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome [11].
• The lengthening of SNRT in the majority of patients with sick sinus syndrome implies that ethmozin might prolong post-tachycardia pauses in these patients [12].
• Symptomatic sick sinus syndrome due to guanethidine. Case report [13].
• Comparison of effects of propranolol versus pindolol on sinus rate and pacing frequency in sick sinus syndrome [14].
• Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration [15].

Biological context of Sick Sinus Syndrome

• We studied heart rate response and blood lactate changes during treadmill exercise testing in 10 patients with sick sinus syndrome (SSS) and normal atrioventricular (AV) conduction in whom an activity detecting multi-programmable rate responsive pacemaker was implanted for atrial pacing (AAI pacing) [16].
• Specific binding sites for insulin-like growth factor I (IGF-I) and their expression during cardiac myocyte hypertrophy were studied by autoradiographic analysis of right ventricular biopsy specimens from patients with hypertrophic cardiomyopathy (9 cases), dilated cardiomyopathy (8 cases), and sick sinus syndrome (5 cases) [17].

Anatomical context of Sick Sinus Syndrome

• Six complications were noted in the SLE group, including 2 early, nonrecurrent dislocations, 1 patient with thigh pain for 1 year, 1 pericarditis, 1 sick-sinus syndrome, and 1 urinary tract infection [18].
• A patient with the sick sinus syndrome accompanying mirror-image dextrocardia which was associated with double superior venae cavae and an absent inferior vena cava is presented [19].
• Thus, carotid sinus massage and, to some extent, isoprenaline administration appear simple bedside tests which may be helpful in identifying the underlying mechanism of sick sinus syndrome [20].
• Simultaneous right and left ventricular pacing was performed in a 73-year-old man with coronary artery disease end-stage congestive heart failure and a DDD pacemaker implanted for sick sinus syndrome [21].
• Congenital absence of the pericardium associated with atrial septal defect and sick sinus syndrome [22].

Gene context of Sick Sinus Syndrome

• There was no significant difference in plasma PF4 and beta thromboglobulin between patients with complete heart block and sick sinus syndrome in the corresponding pacing mode [23].
• The criteria of EP30 < 3.0 microV and ED4 > 22 ms as atrial early potential gave a sensitivity of 76%, a specificity of 91%, a positive predictive value of 74% and a negative predictive value of 93% for identification of patients with sick sinus syndrome [24].
• We describe the case of a 42-year-old woman with a rare combination of congenital pericardial absence, atrial septal defect within the fossa ovalis and sick sinus syndrome [22].
• Two patients with sick sinus syndrome were temporarily paced using APC Devices pacemaker models EC 4542 and EV 4543 respectively, which showed transient increase (53% and 83% of the preset rate, respectively) in pacing rate [25].
• This study examined the functions of the DDD/AMC mode in 12 patients with sick sinus syndrome (SSS; n = 10) or paroxysmal complete AVB (n = 2) [26].

Analytical, diagnostic and therapeutic context of Sick Sinus Syndrome

• Intravenous adenosine: a noninvasive diagnostic test for sick sinus syndrome [27].
• These include three patients with cardiac manifestations (sick sinus syndrome, obstructive cardiomyopathy and ischemic ECG changes) [28].
• Holter monitoring showed that sick sinus syndrome patients remained in paced rhythm, either DDD or VVI, for most of the 24 hour period [29].
• The number of alpha 1 grains in patients with LBBB-VT was apparently higher than in the control group, sick sinus syndrome (SSS; 11.2), and the beta-AR density in the LBBB-VT group was the same as in the control group (SSS; 15.4) [30].
• The clinical value of rapid intravenous injection of adenosine triphosphate (ATP, Adephos Kowa # L3, CAS 56-65-5) for assessing sinus node function was examined in 5 patients with sick sinus syndrome (SSS) and 6 normal controls [31].

References