Disease relevance of NSC 8484

• Subacute oral toxicity of tri-n-butyl phosphate in the Sprague-Dawley rat [1].
• Tri (n-butyl) phosphate (TNBP)-split vaccine containing 6400 CCA units of influenza virus A/Aichi/68 (H3N2) was given intramuscularly to a group of volunteers [2].
• Induction of urinary bladder hyperplasia in Sprague-Dawley rats orally administered tri-n-butyl phosphate [3].
• Cold supernatant which was prepared from factor VIII:C containing cryoprecipitate was seeded with HIV-1, then treated with a mixture of tri (n-butyl) phosphate (TNBP) and triton X-100 [4].
• Semi-processed human factor VIII (FVIII) product experimentally contaminated with Sindbis virus was used to test a solvent-detergent treatment with tri-N-butyl-phosphate (TNBP) and Tween 80 [5].

Psychiatry related information on NSC 8484

• Antioxidant defense mechanisms in the lung toxicity of tri-n-butyl phosphate [6].

High impact information on NSC 8484

• Hemagglutinin from influenza A/PR8 virus was purified after treatment of the virus with sodium deoxycholate followed by extraction with tri-n-butyl phosphate [7].
• This plasticiser effect was almost completely reversible, when tributyl phosphate was desorbed from the membranes [8].
• Both the TBP and the ether-treated monovalent B/Hong Kong vaccines also induced lower heterologous GMT's to B/Mass in initially seronegative individuals [9].
• The detection limits from blood plasma were 50 ngL(-1) (tripropyl phosphate), 17 ngL(-1) (tributyl phosphate), 240 ngL(-1) (tris(2-chloroethyl) phosphate) and 24 ngL(-1) (triphenyl phosphate) [10].
• In the present study, curcumin from Chinese herbal medicine turmeric was determined by capillary electrophoresis with amperometric detection (CE-AD) pretreated by a self-designed, simple, inexpensive solid-phase extraction (SPE) cartridge based on the material of tributyl phosphate resin [11].

Chemical compound and disease context of NSC 8484

• Two nano-emulsion formulations (8N8 and 20N10) made from soybean oil, tributyl phosphate and Triton X-100, were tested for their ability to prevent murine influenza virus pneumonia in vivo [12].
• Skydrol 500B-4 fire resistant hydraulic fluid, a proprietary phosphate ester mixture composed principally of dibutyl phenyl phosphate (DBPP) and tributyl phosphate (TBP) and used as a commercial airline hydraulic fluid, was evaluated in an inhalation toxicity study of Sprague-Dawley rats [13].

Biological context of NSC 8484

• Efficacy of 3,4,3-LIHOPO for reducing the retention of 238Pu in rat after inhalation of the tributyl phosphate complex [14].
• In order to study the decontamination nature of the reactive extraction of uranium in the presence of some metal chemicals using a single-phase mixture of HNO(3), H(2)O and tri-n-butylphosphate (TBP) in supercritical carbon dioxide (SC-CO(2)), we measured the decontamination factors (DFs) of Sr, Zr, Mo, Ru, Pd, Ce and Nd from their mixture with U [15].

Anatomical context of NSC 8484

• Effects of tri-n-butyl phosphate on the peripheral nervous system of the Sprague-Dawley rat [16].
• Tributyl phosphate (TBP) produces tumors of the bladder urothelium in rats at high doses (700 and 3000 ppm), with greater effects in males than in females [17].
• Tributyl phosphate effects on urine and bladder epithelium in male Sprague-Dawley rats [17].
• Of 16 human adipose tissue samples analyzed, 5 contained tris(1,3-dichloropropyl) phosphate in the range of 0.5 to 110 ng/g, 4 contained tributoxyethyl phosphate in the range of 4.0 to 26.8 ng/g, and one contained tributyl phosphate at 9.0 ng/g [18].

Associations of NSC 8484 with other chemical compounds

• Elution gas chromatography has been used to study complexing of hydrazoic acid with tributyl phosphate (TBP) in hexadecane solution in the presence of nitric acid and/or uranyl nitrate [19].
• The solubilization of tributylphosphate (TBP), a polar oil, in various micellar solutions of Pluronic has been investigated by (1)H NMR spectroscopy [20].
• After treatment with acids, these elements are separated from matrix elements by simultaneous solvent extraction of 5,5'-methylenedisalicylohydroxamic acid complexes from HCl/NaClO4 solution into an isobutyl methyl ketone/tributyl phosphate solution [21].
• Sample calibration was performed with tributyl phosphate purchased from Aldrich (USP Reference Standard is not available) [22].
• A silver ion-selective electrode was prepared with a polymeric membrane incorporating 2,6-bis-methylsulfanyl-[1,3,5]thiadiazine-4-thione as an ionophore, tri-n-butylphosphate (TBP) as a plasticizer and sodium tetraphenylborate (NaTPB) as an additive [23].

Gene context of NSC 8484

• To separate and quantify urinary porphyrins, acidified and centrifuged urine was injected on a reversed-phase high-performance liquid chromatographic column, LiChrosorb RP-18, coated with tributylphosphate [24].
• The tendency to form microemulsions follows TRPO > DiAMP > TBP [25].
• Solubilization of tributylphosphate (TBP), a polar oil, in various micellar solutions of Pluronic has been investigated by turbidimetry emphasizing the effect of temperature and the role of the PPO and PEO blocks on the phase behavior of the three components systems (Pluronic-TBP-water) [26].

Analytical, diagnostic and therapeutic context of NSC 8484

• It involves DEAE chromatography, sulfopropyl (S) cation chromatography, tri-n-butyl phosphate (TNBP)-cholate treatment, a second S cation chromatography, freeze-drying and dry-heat [27].
• Pneumotoxic effects of the tri-n-butyl phosphate (TBP) are investigated on rats using biological markers in bronchoalveolar lavage fluid (BALF) and studying key antioxidant enzymes in lung homogenate [6].
• While virus inactivation with TNBP/Tween 80 was slower, effective inactivation of Sindbis, HSV-1, VSV and human immunodeficiency virus type-1, i.e. 4.1-->6.3 log, occurred within 30 minutes [28].

References