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Chemical Compound Review

CHEMBL312487     6-phenylazanylquinoline-5,8- dione

Synonyms: SureCN970943, AG-A-88906, AG-J-59005, BSPBio_001225, KBioGR_000565, ...
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Disease relevance of nchembio762-comp2


Psychiatry related information on nchembio762-comp2

  • Bilateral intrahippocampal administration of LY 83583 (2.5 micrograms per side) caused full amnesia for inhibitory avoidance when given immediately (0 min) after training, but not 30 min post-training [3].

High impact information on nchembio762-comp2

  • Postcapillary endothelial cell migration and growth induced by VEGF were blocked by both the NO synthase inhibitor Nomega-mono-methyl--arginine and by the guanylate cyclase inhibitor LY 83583 [4].
  • The enhanced production and secretion of CNP, caused by either ANP or BNP, was significantly prevented by LY 83583, an inhibitor of cGMP generation, and was also attenuated by KT 5823, an inhibitor of cGMP-dependent protein kinase [5].
  • L-NAME, LY 83583 (6-Anilino-5,8-quinolinedione, a soluble guanylate cyclase inhibitor), and Rp-8-Bromo-cGMPS (Rp-8-Bromo-guanosine 3',5'-cyclic monophosphothioate, a cGMP-dependent protein kinase inhibitor) significantly inhibited the hypoxia-induced increase in medium levels of EPO in Hep3B cells [6].
  • CCK treatment induced an increase of intracellular cGMP concentrations, but concomitant addition of LY 83583 virtually suppressed this increase [7].
  • Incubation with H(2)O(2) (500 microM) or the redox cycler LY-83583 (10 microM) profoundly increased the ROS concentration to 3- and 4-fold and induced apoptosis in HUVECs [8].

Biological context of nchembio762-comp2


Anatomical context of nchembio762-comp2


Associations of nchembio762-comp2 with other chemical compounds


Gene context of nchembio762-comp2

  • The SNP-mediated decreases in VEGF expression were associated with increases in intracellular cGMP and were blocked by LY 83583 [12].
  • It was observed that incubation of the monolayers with the GC inhibitor LY-83583 (10 microM) did not alter the VEGF-mediated LP: response [23].
  • NO inhibition of SP-B mRNA levels was not blocked by LY-83583 and KT-5823, inhibitors of soluble guanylate cyclase and protein kinase G, respectively [24].
  • NNLA, 7-NI, and LY 83583 eliminated enhancements of NOS activity and cGMP level, whereas glucocorticoid remained without effect [25].
  • Induction of HO-1 mRNA was independent of the guanylate cyclase signaling pathway; addition of the analogue 8-bromo-cyclic GMP did not induce the HO-1 transcript, and the soluble guanylate cyclase inhibitor LY-83583 did not block HO-1 induction by NO in IMR-90 cells [26].

Analytical, diagnostic and therapeutic context of nchembio762-comp2


  1. Mechanism of potentiation of LY83583-induced growth inhibition by sodium nitroprusside in human brain tumor cells. Lee, Y.S., Wurster, R.D. Cancer Chemother. Pharmacol. (1995) [Pubmed]
  2. Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation. Cherry, P.D., Omar, H.A., Farrell, K.A., Stuart, J.S., Wolin, M.S. Am. J. Physiol. (1990) [Pubmed]
  3. Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation. Bernabeu, R., Schroder, N., Quevedo, J., Cammarota, M., Izquierdo, I., Medina, J.H. Neuroreport (1997) [Pubmed]
  4. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H.T., Donnini, S., Granger, H.J., Bicknell, R. J. Clin. Invest. (1997) [Pubmed]
  5. Atrial and brain natriuretic peptides stimulate the production and secretion of C-type natriuretic peptide from bovine aortic endothelial cells. Nazario, B., Hu, R.M., Pedram, A., Prins, B., Levin, E.R. J. Clin. Invest. (1995) [Pubmed]
  6. Interaction of nitric oxide and cyclic guanosine 3',5'-monophosphate in erythropoietin production. Ohigashi, T., Brookins, J., Fisher, J.W. J. Clin. Invest. (1993) [Pubmed]
  7. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5. Cordelier, P., Estève, J.P., Bousquet, C., Delesque, N., O'Carroll, A.M., Schally, A.V., Vaysse, N., Susini, C., Buscail, L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Dernbach, E., Urbich, C., Brandes, R.P., Hofmann, W.K., Zeiher, A.M., Dimmeler, S. Blood (2004) [Pubmed]
  9. Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. Sengenes, C., Bouloumie, A., Hauner, H., Berlan, M., Busse, R., Lafontan, M., Galitzky, J. J. Biol. Chem. (2003) [Pubmed]
  10. Exogenous nitric oxide elicits chemotaxis of neutrophils in vitro. Beauvais, F., Michel, L., Dubertret, L. J. Cell. Physiol. (1995) [Pubmed]
  11. Effect of isosorbiddinitrate on exogenously expressed slowly activating K+ channels and endogenous K+ channels in Xenopus oocytes. Busch, A.E., Kopp, H.G., Waldegger, S., Samarzija, I., Süssbrich, H., Raber, G., Kunzelmann, K., Ruppersberg, J.P., Lang, F. J. Physiol. (Lond.) (1996) [Pubmed]
  12. Suppression of hypoxia-associated vascular endothelial growth factor gene expression by nitric oxide via cGMP. Ghiso, N., Rohan, R.M., Amano, S., Garland, R., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  13. Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation. MacLeod, K.M., Ng, D.D., Harris, K.H., Diamond, J. Mol. Pharmacol. (1987) [Pubmed]
  14. Effect of atrial natriuretic factor on Na+-K+-Cl- cotransport of vascular smooth muscle cells. Owen, N.E., Bush, E.N., Holleman, W., O'Donnell, M.E. Hypertension (1987) [Pubmed]
  15. Actions of C-type natriuretic peptide and sodium nitroprusside on carbachol-stimulated inositol phosphate formation and contraction in ciliary and iris sphincter smooth muscles. Ding, K.H., Abdel-Latif, A.A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  16. Block of cyclic nucleotide-gated channels in salamander olfactory receptor neurons by the guanylyl cyclase inhibitor LY83583. Leinders-Zufall, T., Zufall, F. J. Neurophysiol. (1995) [Pubmed]
  17. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Lüönd, R.M., McKie, J.H., Douglas, K.T. Biochem. Pharmacol. (1993) [Pubmed]
  18. Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated pathway. Clifton, V.L., Read, M.A., Leitch, I.M., Giles, W.B., Boura, A.L., Robinson, P.J., Smith, R. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  19. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation. Murphy, T.H., So, A.P., Vincent, S.R. J. Neurochem. (1998) [Pubmed]
  20. Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils. Wanikiat, P., Woodward, D.F., Armstrong, R.A. Br. J. Pharmacol. (1997) [Pubmed]
  21. Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Li, J., Hu, X., Selvakumar, P., Russell, R.R., Cushman, S.W., Holman, G.D., Young, L.H. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  22. NO increases permeability of cultured human cervical epithelia by cGMP-mediated increase in G-actin. Gorodeski, G.I. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  23. Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO. Lakshminarayanan, S., Antonetti, D.A., Gardner, T.W., Tarbell, J.M. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  24. Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells. Salinas, D., Sparkman, L., Berhane, K., Boggaram, V. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  25. Biphasic enhancement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils. Strosznajder, J., Chalimoniuk, M. Acta neurobiologiae experimentalis. (1996) [Pubmed]
  26. Complex genetic response of human cells to sublethal levels of pure nitric oxide. Marquis, J.C., Demple, B. Cancer Res. (1998) [Pubmed]
  27. Mangafodipir (MnDPDP)-and MnCl2-induced endothelium-dependent relaxation in bovine mesenteric arteries. Asplund, A., Grant, D., Karlsson, J.O. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  28. Cyclic GMP modulators on vascular adrenergic neurotransmission. Tesfamariam, B., Weisbrod, R.M., Cohen, R.A. J. Vasc. Res. (1992) [Pubmed]
  29. Nitric oxide-mediated excitatory effect on neurons of dorsal motor nucleus of vagus. Travagli, R.A., Gillis, R.A. Am. J. Physiol. (1994) [Pubmed]
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