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Gene Review

Olig1  -  oligodendrocyte transcription factor 1

Rattus norvegicus

Synonyms: Olg-1 bHLH protein, Oligo1, Oligodendrocyte transcription factor 1
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Disease relevance of Olig1

  • Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis [1].
  • This conclusion was confirmed by using a mutant of E. coli K1 that was defective in the synthesis of poly(sialic acid) and could only transfer sialic acid to exogenous acceptors of oligo- or poly(sialic acid) [2].
  • This suggests that new oligo- or polysynaptic connections become functional under the influence of a myositis [3].
  • Oligo- or azoospermia can arise for similar reasons in men [4].
  • On GD 13 brachy-, oligo-, and syndactyly of the forepaw were induced, and of the hindpaw on GD 14 [5].

High impact information on Olig1


Chemical compound and disease context of Olig1

  • The exposure of men to the nematocide dibromochloropropane (DBCP) has caused prolonged oligo- and azoospermia, which occasionally reverses spontaneously [9].
  • Both groups of animals were treated daily intraperitoneally with AS and a mismatched control oligo (CO) (3 mg/kg), and orally with meloxicam (7.5 mg/kg) 1 h before induction of colitis [10].

Biological context of Olig1

  • In many cases, HLH proteins such as Olig1 and Olig2 heterodimerize with other HLH proteins, such as members of the E subfamily, which are critical regulators of cell proliferation and differentiation [11].
  • We propose that E2A and/or HEB, possibly in combination with Olig1 and 2, are critical components of oligodendrogenesis and may regulate cell survival, proliferation, and fate decisions in the oligodendrocyte lineage [11].
  • The two pools (oligo 1 and oligo 2), each containing 24 oligodeoxyribonucleotides, were first used as primers to initiate reverse transcription of rat liver mRNA [12].
  • One of the pools (oligo 1) was found to prime a specific 32P-labeled cDNA of approximately 160 nucleotides that contained the anticoding sequence corresponding exactly to the amino acid sequence of rat angiotensin [12].
  • The poly A+mRNA isolated on an oligo (dT) cellulose column had an average nucleotide length of 1300 to 1800 and its c (complementary) DNA was 600 to 1400 base pairs [13].

Anatomical context of Olig1

  • Similarly, cells bearing the morphology of oligodendrocyte precursors expressed both Olig1 and HEB or E2A [11].
  • Although cells expressing Olig1, Olig2, and proteolipid protein were attracted to demyelinated sites in the course of chronic inflammation, myelin loss was not associated with the effects of inflammation on OPC reactivity [14].
  • The remyelination that follows brain lesions is dependent on the recruitment of oligodendrocyte progenitor cells (OPCs) and expression of genes controlling differentiation and myelin production, such as Olig1 and Olig2 bHLH transcription factors [14].
  • A membranous sialytransferase from E. coli K1 that can transfer sialic acid to exogenous acceptors of oligo- or poly(sialic acid) also recognized rat brain membranes, further substantiating the presence of poly(sialic acid) in rat brain [2].
  • First, the antibody, designated mAb.2-4B, which specifically recognized oligo/poly-Neu5Gc with a degree of polymerization of >2, was developed by establishing a hybridoma cell line from P3U1 myeloma cells fused with splenocytes from an MRL autoimmune mouse immunized with dipalmitoylphosphatidylethanolamine-conjugated oligo/poly-Neu5Gc [15].

Associations of Olig1 with chemical compounds

  • However, the NF-I antibody did not supershift all the DNA-protein complexes, and the supershift band was not increased with nuclear proteins from acetaldehyde-treated cells despite the increased binding of these nuclear protein preparations to the NF-I oligo [16].
  • Such diversity in oligo/poly-Sia structure also implicates a diverged array of biological functions of this glycan unit in glycoproteins [15].
  • The oligo (dT) segments were separated by simple nicks as shown by the ability of T4 DNA ligase to seal the nick after the 3'-phosphate was removed by a phosphatase and the 5' end was phosphorylated with a kinase [17].
  • To precisely localize these RNAs, in situ hybridization with antisense and sense oligo probes labeled with digoxigenin was carried out [18].
  • Female pups either received a lightly androgenizing dose of testosterone 6 h after oligo infusion or were not hormone treated [19].

Physical interactions of Olig1

  • A DNA binding domain of the glucocorticoid receptor interacted with a rat GRE (RGRE) with an apparent affinity intermediate between that of a consensus positive GRE oligo (GRE+) and a mismatch GRE oligo (GRE-) [20].

Regulatory relationships of Olig1

  • Taken together, these results suggest that NT3 induce NSCs to differentiate into OLPs by enhancing the expression of Olig-1 through an Erk1/2-dependent pathway [21].

Other interactions of Olig1


Analytical, diagnostic and therapeutic context of Olig1

  • Immature (A2B5(+)) and more mature (O4(+)) rat oligodendrocyte precursors in dissociated cell culture expressed Olig1 as well as E proteins, HEB and E2A [11].
  • The specificity of its binding to the core promoter was confirmed by competitive electrophoretic mobility shift assay using several unlabeled oligo probes in the assay [26].
  • Rat alpha 1-fetoprotein mRNA was isolated and purified to apparent homogeneity by means of immunoadsorption and oligo (dT) cellulose affinity chromatography [27].
  • Furthermore, although the combination of PS C-raf antisense oligo with sirolimus (SRL) acted synergistically to extend heart allograft survival, the effect was potentiated by either of the ME-modified oligos [28].
  • In addition, the transcript contains a 742-bp intervening sequence (identical to the complete terminal intron) between the last and penultimate exons, and an intron-specific oligo probe for Northern blotting demonstrates the presence of the variant transcript in liver of MSG-treated rats [29].


  1. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Arnett, H.A., Fancy, S.P., Alberta, J.A., Zhao, C., Plant, S.R., Kaing, S., Raine, C.S., Rowitch, D.H., Franklin, R.J., Stiles, C.D. Science (2004) [Pubmed]
  2. Use of prokaryotic-derived probes to identify poly(sialic acid) in neonatal neuronal membranes. Vimr, E.R., McCoy, R.D., Vollger, H.F., Wilkison, N.C., Troy, F.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Functional reorganization in the rat dorsal horn during an experimental myositis. Hoheisel, U., Koch, K., Mense, S. Pain (1994) [Pubmed]
  4. Transplantation of intact rat gonads using vascular anastomosis: effects of cryopreservation, ischaemia and genotype. Yin, H., Wang, X., Kim, S.S., Chen, H., Tan, S.L., Gosden, R.G. Hum. Reprod. (2003) [Pubmed]
  5. Stage-specific skeletal and visceral defects of the I(Kr)-blocker almokalant: further evidence for teratogenicity via a hypoxia-related mechanism. Sköld, A.C., Wellfelt, K., Danielsson, B.R. Teratology (2001) [Pubmed]
  6. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D., Rowitch, D.H. Cell (2002) [Pubmed]
  7. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Zhou, Q., Anderson, D.J. Cell (2002) [Pubmed]
  8. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Chang, C.S., Kokontis, J., Liao, S.T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  9. Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Meistrich, M.L., Wilson, G., Porter, K.L., Huhtaniemi, I., Shetty, G., Shuttlesworth, G.A. Toxicol. Sci. (2003) [Pubmed]
  10. Cyclooxygenase-2 inhibition and experimental colitis: beneficial effects of phosphorothioated antisense oligonucleotide and meloxicam. Khan, I., Al-Awadi, F.M., Thomas, N., Haridas, S., Anim, J.T. Scand. J. Gastroenterol. (2002) [Pubmed]
  11. Extracellular and intracellular regulation of oligodendrocyte development: roles of Sonic hedgehog and expression of E proteins. Sussman, C.R., Davies, J.E., Miller, R.H. Glia (2002) [Pubmed]
  12. Cloning and sequence analysis of cDNA for rat angiotensinogen. Ohkubo, H., Kageyama, R., Ujihara, M., Hirose, T., Inayama, S., Nakanishi, S. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  13. Messenger RNA content and complexity in normal and overloaded rat heart: a preliminary report. Swynghedauw, B., Moalic, J.M., Bouveret, P., Bercovici, J., de la Bastie, D., Schwartz, K. Eur. Heart J. (1984) [Pubmed]
  14. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. Glezer, I., Lapointe, A., Rivest, S. FASEB J. (2006) [Pubmed]
  15. Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoproteins by a newly developed immunochemical reagent and biochemical methods. Sato, C., Kitajima, K., Inoue, S., Inoue, Y. J. Biol. Chem. (1998) [Pubmed]
  16. Effects of acetaldehyde on nuclear protein binding to the nuclear factor I consensus sequence in the alpha 2(I) collagen promoter. Anania, F.A., Potter, J.J., Rennie-Tankersley, L., Mezey, E. Hepatology (1995) [Pubmed]
  17. Chromatin 3'-phosphatase/5'-OH kinase cannot transfer phosphate from 3' to 5' across a strand nick in DNA. Habraken, Y., Verly, W.G. Nucleic Acids Res. (1986) [Pubmed]
  18. U1 and U2 snRNA are localized in the sperm nucleus. Concha, I.I., Urzua, U., Yañez, A., Schroeder, R., Pessot, C., Burzio, L.O. Exp. Cell Res. (1993) [Pubmed]
  19. Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain. McCarthy, M.M., Schlenker, E.H., Pfaff, D.W. Endocrinology (1993) [Pubmed]
  20. Proenkephalin gene expression: interaction of glucocorticoid and cAMP regulatory elements. Jenab, S., Inturrisi, C.E. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  21. Erk1/2 but not PI3K pathway is required for neurotrophin 3-induced oligodendrocyte differentiation of post-natal neural stem cells. Hu, X., Jin, L., Feng, L. J. Neurochem. (2004) [Pubmed]
  22. Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Wu, Y., Liu, Y., Levine, E.M., Rao, M.S. Dev. Dyn. (2003) [Pubmed]
  23. Roles of protein kinase C in regulation of P2X7 receptor-mediated calcium signalling of cultured type-2 astrocyte cell line, RBA-2. Hung, A.C., Chu, Y.J., Lin, Y.H., Weng, J.Y., Chen, H.B., Au, Y.C., Sun, S.H. Cell. Signal. (2005) [Pubmed]
  24. Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension. Tahira, Y., Fukuda, N., Endo, M., Suzuki, R., Ikeda, Y., Takagi, H., Matsumoto, K., Kanmatsuse, K. Hypertens. Res. (2002) [Pubmed]
  25. Specific suppression of interleukin 2 biosynthesis by synthetic antisense oligodeoxynucleotides does not influence allograft rejection. Yun, S., Sawyer, G.J., Zhang, X., Gustafsson, K., Fabre, J.W. Transplantation (2000) [Pubmed]
  26. Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription. Liu, Z., Jacob, S.T. J. Biol. Chem. (1994) [Pubmed]
  27. alpha 1-Fetoprotein mRNA of rat yolk sac and hepatoma. Chiu, J.F., Decha-Umphai, W., Commer, P. Nucleic Acids Res. (1979) [Pubmed]
  28. Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats. Stepkowski, S.M., Qu, X., Wang, M.E., Tian, L., Chen, W., Wancewicz, E.V., Johnston, J.F., Bennett, C.F., Monia, B.P. Transplantation (2000) [Pubmed]
  29. Nominal growth hormone pulses in otherwise normal masculine plasma profiles induce intron retention of overexpressed hepatic CYP2C11 with associated nuclear splicing deficiency. Pampori, N.A., Shapiro, B.H. Endocrinology (2000) [Pubmed]
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