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Chemical Compound Review

AG-F-79659     icosa-2,4,6,8-tetraynoic acid

Synonyms: AC1Q5BPM, CTK1H3248, AR-1J2206, AC1L361W, 52642-57-6, ...
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Disease relevance of Eicosatetraynoic acid


High impact information on Eicosatetraynoic acid


Chemical compound and disease context of Eicosatetraynoic acid


Biological context of Eicosatetraynoic acid


Anatomical context of Eicosatetraynoic acid


Associations of Eicosatetraynoic acid with other chemical compounds


Gene context of Eicosatetraynoic acid


Analytical, diagnostic and therapeutic context of Eicosatetraynoic acid


  1. Role of lipoxygenase metabolites in ischemic preconditioning. Murphy, E., Glasgow, W., Fralix, T., Steenbergen, C. Circ. Res. (1995) [Pubmed]
  2. Human PC-3 prostate cell line DNA synthesis is suppressed by eicosatetraynoic acid, an in vitro inhibitor of arachidonic acid metabolism. Anderson, K.M., Wygodny, J.B., Ondrey, F., Harris, J. Prostate (1988) [Pubmed]
  3. Inhibitors of the lipoxygenase pathway specifically block orthopoxvirus replication. Palumbo, G.J., Buller, R.M. Virology (1991) [Pubmed]
  4. Nerve growth factor rapidly stimulates arachidonate metabolism in PC12 cells: potential involvement in nerve fiber growth. DeGeorge, J.J., Walenga, R., Carbonetto, S. J. Neurosci. Res. (1988) [Pubmed]
  5. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Wu, Z., Xie, Y., Bucher, N.L., Farmer, S.R. Genes Dev. (1995) [Pubmed]
  6. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J.C., Staels, B., Auwerx, J. J. Clin. Invest. (1995) [Pubmed]
  7. Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. Lin, A.H., Morton, D.R., Gorman, R.R. J. Clin. Invest. (1982) [Pubmed]
  8. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Coffey, M.J., Natarajan, R., Chumley, P.H., Coles, B., Thimmalapura, P.R., Nowell, M., Kühn, H., Lewis, M.J., Freeman, B.A., O'Donnell, V.B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Kalgutkar, A.S., Crews, B.C., Rowlinson, S.W., Marnett, A.B., Kozak, K.R., Remmel, R.P., Marnett, L.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  10. Prostacyclin (PGI2) mediates hypoxic relaxation of bovine coronary arterial strips. Roberts, A.M., Messina, E.J., Kaley, G. Prostaglandins (1981) [Pubmed]
  11. Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. Li, Y., Kang, J.X., Leaf, A. Prostaglandins (1997) [Pubmed]
  12. Regulation of alpha-foetoprotein gene expression by fatty acids and fibrates. Bois-Joyeux, B., Cailliau, K., Danan, J.L. Prostaglandins Leukot. Essent. Fatty Acids (1999) [Pubmed]
  13. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Brodowsky, I.D., Hamberg, M., Oliw, E.H. Eur. J. Pharmacol. (1994) [Pubmed]
  14. PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Keller, H., Devchand, P.R., Perroud, M., Wahli, W. Biol. Chem. (1997) [Pubmed]
  15. Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. Wilson, D.E., DiGianfilippo, A., Ondrey, F.G., Anderson, K.M., Harris, J.E. J. Neurosurg. (1989) [Pubmed]
  16. Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death. MacCarrone, M., Van Zadelhoff, G., Veldink, G.A., Vliegenthart, J.F., Finazzi-Agrò, A. Eur. J. Biochem. (2000) [Pubmed]
  17. Inhibition of lung tissue oxidation during ischemia/reperfusion by 2-mercaptopropionylglycine. Ayene, I.S., al-Mehdi, A.B., Fisher, A.B. Arch. Biochem. Biophys. (1993) [Pubmed]
  18. 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. Wijkander, J., O'Flaherty, J.T., Nixon, A.B., Wykle, R.L. J. Biol. Chem. (1995) [Pubmed]
  19. Structural stability of soybean lipoxygenase-1 in solution as probed by small angle X-ray scattering. Dainese, E., Sabatucci, A., van Zadelhoff, G., Angelucci, C.B., Vachette, P., Veldink, G.A., Agrò, A.F., Maccarrone, M. J. Mol. Biol. (2005) [Pubmed]
  20. Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor. Nolan, R.D., Danilowicz, R.M., Eling, T.E. Mol. Pharmacol. (1988) [Pubmed]
  21. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. Rankin, S.M., Parthasarathy, S., Steinberg, D. J. Lipid Res. (1991) [Pubmed]
  22. Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta. Meier, R.W., Niklaus, G., Dewald, B., Fey, M.F., Tobler, A. J. Cell. Physiol. (1995) [Pubmed]
  23. An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells. Suga, K., Kawasaki, T., Blank, M.L., Snyder, F. J. Biol. Chem. (1990) [Pubmed]
  24. The pharmacologic modulation of mediator release from human basophils. Warner, J.A., MacGlashan, D.W., Peters, S.P., Kagey-Sobotka, A., Lichtenstein, L.M. J. Allergy Clin. Immunol. (1988) [Pubmed]
  25. Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis. Burka, J.F., Flower, R.J. Br. J. Pharmacol. (1979) [Pubmed]
  26. Effects of eicosatetraynoic acid (ETYA) on cultured pig thyroid cells. Relationships between the inhibition of the phosphatidate-phosphatidyl inositol cycle, the iodination and the cyclic AMP responsiveness to thyrotropin. Haye, B., Gerard, C., Jacquemin, C. FEBS Lett. (1982) [Pubmed]
  27. Biosynthesis of lipoxygenase products by enzyme preparations from normal and psoriatic skin. Ziboh, V.A., Casebolt, T.L., Marcelo, C.L., Voorhees, J.J. J. Invest. Dermatol. (1984) [Pubmed]
  28. A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. Peri, K.G., Almazan, G., Varma, D.R., Chemtob, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  29. Polyunsaturated fatty acids regulate lipogenic and peroxisomal gene expression by independent mechanisms. Clarke, S.D., Jump, D. Prostaglandins Leukot. Essent. Fatty Acids (1997) [Pubmed]
  30. Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. Fedyk, E.R., Phipps, R.P. Int. J. Immunopharmacol. (1994) [Pubmed]
  31. Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta. Rapoport, R.M., Draznin, M.B., Murad, F. Circ. Res. (1984) [Pubmed]
  32. Measurement of 5,8,11, 14-icosatetraynoic acid in plasma by gas-liquid chromatography. Goodman, R.P., Brash, A.R. J. Lipid Res. (1981) [Pubmed]
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