Disease relevance of STRONTIUM CHLORIDE

• OBJECTIVE--To present the current state of systemic radiopharmaceutical therapy for the palliation of pain in individuals with metastatic cancer and to evaluate the palliative effect and degree of hemotoxicity of strontium chloride 89 (89Sr) in patients with painful osteoblastic metastases primarily from prostate and breast cancer [1].
• Efficacy of strontium chloride in dental hypersensitivity [2].
• METHODS: A model of strontium biodistribution similar to the one created by the International Commission on Radiological Protection (ICRP) was applied for activity and absorbed dose calculations in a patient with bone metastases treated with Sr-89 strontium chloride [3].
• Strontium chloride Sr 89 for treating pain from metastatic bone disease [4].
• Short-term toxicity of strontium chloride in rats [5].

High impact information on STRONTIUM CHLORIDE

• This increase in transgene expression was also observed at 6 h after 1,25-(OH)2D3 treatment in animals on a low calcium diet (25.2+/-7.7-fold) as well as in transgenic mice fed a vitamin D-deficient diet containing strontium chloride to block endogenous 1,25-(OH)2D3 production (7.5+/-0.9-fold) [6].
• The distribution of divalent ions in semidilute solutions of high-molecular-mass DNA containing both sodium chloride and strontium chloride in near-physiological conditions is studied by small-angle x-ray scattering and by small-angle neutron scattering [7].
• Therefore, we investigated the reproducibility of the absolute bioavailability of strontium chloride, a marker for intestinal calcium absorption, in healthy male volunteers (n = 8) by measuring the area under the plasma strontium concentration-time curve after oral and intravenous administration of strontium [8].
• No parthenogenetic activation was observed in the oocytes treated with 8% EtOH for 8-11 min, 1.7 mM and 5.0 mM SrCl2 for 1 hr, 100 microM and 400 microM CHX for 2 hr, and 81 nM and 162 nM PMA for 5 min [9].
• Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility [10].

Chemical compound and disease context of STRONTIUM CHLORIDE

• Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone [11].
• Reducing dentinal hypersensitivity with strontium chloride and potassium nitrate [12].
• Of the 104 isolations of Salmonella sp. from egg pulp, 97 were obtained from strontium chloride M broth, 42 from strontium selenite broth and 57 from strontium selenite A broth [13].
• SUMMARY BACKGROUND DATA: Attempts have been made to treat dental hypersensitivity by sealing exposed dentinal tubules, primarily using fluoride preparations, strontium chloride, and hydroxyapatite [14].
• Comparative study of effectiveness of strontium chloride and formalin containing dentifrices in relieving dental hypersensitivity [15].

Biological context of STRONTIUM CHLORIDE

• 1. The absorption kinetics of orally administered strontium chloride and its reproducibility were investigated in healthy volunteers after administering strontium either under fasting conditions (study I, n = 8) or in combination with a standardized meal (study II, n = 8) [10].
• The brief exposure of recently ovulated mouse oocytes to M16 embryo culture medium supplemented with strontium chloride (M16 Sr2+) for 2-10 min was observed to induce a high incidence of parthenogenesis [16].
• Forty-one patients with multiple osseous metastases due to prostate and breast cancer were treated with strontium chloride 89 (89Sr) at the department of radiation oncology, in a university hospital [17].

Anatomical context of STRONTIUM CHLORIDE

• Spermatozoa were exposed to calcium-depleted medium containing strontium chloride for 20 to 24 hours before resuspension in medium containing calcium to induce capacitation [18].
• Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery [19].
• Strontium chloride absorbed on absorbable gelatin sponge, U.S.P. appears to stimulate the formation of bone in the maxilla of Sprague Dawley rats [20].
• Clastogenic activity of strontium chloride on bone marrow cells in vivo [21].
• Influence of strontium chloride on blood platelet function [22].

Associations of STRONTIUM CHLORIDE with other chemical compounds

• Tree frogs, either with or without calcium chloride preloading, were maintained in a 0.8% strontium chloride solution for 1 week, then studied by X-ray microanalysis and scanning electron microscopy to determine the distribution of incorporated strontium in the endolymphatic crystals [23].
• Bovine oocytes were in vitro matured for 24, 26, 28, and 30 h, and treated with ethanol (E, 7% for 5 min) or strontium chloride (S, 10mM SrCl(2) for 5h) alone or in combination: ethanol+strontium (ES) and strontium+ethanol (SE) [24].
• 2 strontium chloride hexahydrate-containing dentifrices (SCH), similar except for their respective abrasive systems, diatomaceous earth or silica-based, were compared for their effects on plaque accumulation and gingival inflammation as part of a 2-month randomised double-blind parallel clinical study [25].
• There was a significant decrease in the sensitivity of the exposed cervical dentin after treatment with sodium fluoride solution with or without pretreatment with strontium chloride solution [26].
• An evaluation of four desensitizing agents for treatment of the post preparation tooth pain: silver nitrate, potassium nitrate, strontium chloride and ferric oxalate [27].

Gene context of STRONTIUM CHLORIDE

• 2 strontium chloride hexahydrate-containing dentifrices (SCH), similar except for their respective abrasive systems, were compared in a 2-month randomised double-blind parallel clinical study to evaluate their comparative effectiveness in terms of cervical dentinal hypersensitivity [28].
• A range-finding experiment with strontium chloride hexahydrate (0, 3, 30, 300 and 3000 ppm in the diet) and subsequently a 90-day test with the same compound at dose levels of 0, 75, 300, 1200 and 4800 ppm in a semipurified diet was carried out with SPF-derived Wistar-rats [5].

Analytical, diagnostic and therapeutic context of STRONTIUM CHLORIDE

• The distribution and incorporation of strontium into bone has been examined in rats, monkeys, and humans after oral administration of strontium (either strontium chloride or strontium ranelate) [29].
• The role of strontium chloride Sr 89 in the palliative treatment of pain associated with metastatic bone disease is reviewed [4].
• The effects of all but the diatomaceous earth/strontium chloride toothpaste would not be inconsistent with previous experience in toothbrushing studies where patients are monitored regularly [30].
• The subcutaneous injection of 0.5 ml of 20% aqueous strontium chloride produced a distinct calciotraumatic response in rat incisor dentine [31].
• The sperms were injected into mouse oocytes by a piezo-micromanipulator, and some of these oocytes were artificially activated with strontium chloride (SrCl2) after ICSI [32].

References