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Chemical Compound Review

AC1NSJYT     2,4-dihydroxybenzenesulfonic acid; N...

Synonyms: AG-E-81070, CTK4F7003, 26055-90-3
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Disease relevance of 2,4-dihydroxybenzenesulfonic acid


High impact information on 2,4-dihydroxybenzenesulfonic acid


Chemical compound and disease context of 2,4-dihydroxybenzenesulfonic acid


Biological context of 2,4-dihydroxybenzenesulfonic acid


Anatomical context of 2,4-dihydroxybenzenesulfonic acid


Associations of 2,4-dihydroxybenzenesulfonic acid with other chemical compounds

  • Here, ethamsylate was investigated for (i) in vivo actions on the free radical-dependent, permeabilizing responses to arachidonic acid and (ii) its antioxidant potential in vitro [5].
  • Desmopressin and ethamsylate were evaluated for possible synergistic effects on the bleeding time [15].
  • In a bid to minimise dosage and possible side-effects when relieving post episiotomy pain, the NSAID Indomethacin was studied in combination with a systemic haemostat Ethamsylate which has been shown to selectively inhibit some prostaglandins [16].
  • There was a non significant trend towards greater efficacy of NSAIDs compared to oral progestogen (luteal phase) and ethamsylate but no differences were demonstrated between NSAIDs and the progesterone releasing intra-uterine system (IUS) and the oral contraceptive pill, although these results were based on very small studies [17].
  • There were no significant differences in the frequency of reported side effects with tranexamic acid when compared to oral luteal phase progestogens (RR 0.4 [0.1, 1.2]) or withdrawal from treatment because of adverse events when compared with NSAIDs and ethamsylate when these treatments were used for heavy menstrual bleeding [13].

Gene context of 2,4-dihydroxybenzenesulfonic acid

  • The rate of bleeding after aspirin preceded by ethamsylate [14.1 (8.5-23.4) microliters 10 min-1] was not significantly different from that after aspirin alone [18].

Analytical, diagnostic and therapeutic context of 2,4-dihydroxybenzenesulfonic acid


  1. Ethamsylate in treatment of menorrhagia. Kasonde, J.M. Lancet (1976) [Pubmed]
  2. A study of the effect of ethamsylate (Dicynene) on the bleeding time, von Willebrand factor level and fibrinolysis in patients with von Willebrand's disease. Hutton, R.A., Hales, M., Kernoff, P.B. Thromb. Haemost. (1988) [Pubmed]
  3. Ethamsylate in the prevention of patent ductus arteriosus. Rosti, L., Piva, D., Rosti, D. Archives of pediatrics & adolescent medicine. (1994) [Pubmed]
  4. A comparative study of ethamsylate and mefenamic acid in dysfunctional uterine bleeding. Chamberlain, G., Freeman, R., Price, F., Kennedy, A., Green, D., Eve, L. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  5. Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate. Hannaert, P., Alvarez-Guerra, M., Hider, H., Chiavaroli, C., Garay, R.P. Eur. J. Pharmacol. (2003) [Pubmed]
  6. A double-blind trial of ethamsylate in the treatment of primary and intrauterine-device menorrhagia. Harrison, R.F., Cambell, S. Lancet (1976) [Pubmed]
  7. Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection. Li, J., Ju, H. Electrophoresis (2006) [Pubmed]
  8. Studies on the action of ethamsylate (Dicynene) on haemostasis. Hutton, R.A., Wickham, E.A., Reed, J.V., Tuddenham, E.G. Thromb. Haemost. (1986) [Pubmed]
  9. Beagle puppy model of intraventricular hemorrhage: ethamsylate studies. Ment, L.R., Stewart, W.B., Duncan, C.C. Prostaglandins (1984) [Pubmed]
  10. The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury. Hernandez, M.R., Alvarez-Guerra, M., Escolar, G., Chiavaroli, C., Hannaert, P., Garay, R.P. Fundamental & clinical pharmacology. (2004) [Pubmed]
  11. Ethamsylate in the treatment of climacteric flushing. Harrison, R.F. Maturitas. (1981) [Pubmed]
  12. The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Alvarez-Guerra, M., Hernandez, M.R., Escolar, G., Chiavaroli, C., Garay, R.P., Hannaert, P. Thromb. Res. (2002) [Pubmed]
  13. Antifibrinolytics for heavy menstrual bleeding. Lethaby, A., Farquhar, C., Cooke, I. Cochrane database of systematic reviews (Online) (2000) [Pubmed]
  14. Beneficial effect of ethamsylate on the relative blood flow of the pancreas in acute canine necrotizing pancreatitis. Wells, A.D., Schenk, W.G. Surgery, gynecology & obstetrics. (1982) [Pubmed]
  15. Synergistic shortening of the bleeding time by desmopressin and ethamsylate in patients with various constitutional bleeding disorders. Kobrinsky, N.L., Israels, E.D., Bickis, M.G. The American journal of pediatric hematology/oncology. (1991) [Pubmed]
  16. Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain. Harrison, R.F., Devitt, M. Irish journal of medical science. (1992) [Pubmed]
  17. Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. Lethaby, A., Augood, C., Duckitt, K. Cochrane database of systematic reviews (Online) (2000) [Pubmed]
  18. Failure of ethamsylate to reduce aspirin-induced gastric mucosal bleeding in humans. Daneshmend, T.K., Stein, A.G., Bhaskar, N.K., Hawkey, C.J. British journal of clinical pharmacology. (1989) [Pubmed]
  19. Multicentre trial of ethamsylate for prevention of periventricular haemorrhage in very low birthweight infants. Benson, J.W., Drayton, M.R., Hayward, C., Murphy, J.F., Osborne, J.P., Rennie, J.M., Schulte, J.F., Speidel, B.D., Cooke, R.W. Lancet (1986) [Pubmed]
  20. Ethamsylate and blood loss in total hip replacement. Keith, I. Anaesthesia. (1979) [Pubmed]
  21. Ethamsylate and lung permeability in ventilated immature newborn rabbits. Amato, M., Sun, B., Robertson, B. Biol. Neonate (1994) [Pubmed]
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