Chemical Compound Review:
Orantinib 3-[2,4-dimethyl-5-[(Z)-(2- oxo-1H-indol-3...
Synonyms:
TSU-68, TSU68, PubChem22441, S1470_Selleck, CHEMBL274654, ...
- The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Smolich, B.D., Yuen, H.A., West, K.A., Giles, F.J., Albitar, M., Cherrington, J.M. Blood (2001)
- In vivo intracellular signaling as a marker of antiangiogenic activity. Solorzano, C.C., Jung, Y.D., Bucana, C.D., McConkey, D.J., Gallick, G.E., McMahon, G., Ellis, L.M. Cancer Res. (2001)
- Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7.2-IgG fusion protein. Huang, X., Wong, M.K., Yi, H., Watkins, S., Laird, A.D., Wolf, S.F., Gorelik, E. Cancer Res. (2002)
- SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Laird, A.D., Vajkoczy, P., Shawver, L.K., Thurnher, A., Liang, C., Mohammadi, M., Schlessinger, J., Ullrich, A., Hubbard, S.R., Blake, R.A., Fong, T.A., Strawn, L.M., Sun, L., Tang, C., Hawtin, R., Tang, F., Shenoy, N., Hirth, K.P., McMahon, G., Cherrington, n.u.l.l. Cancer Res. (2000)
- Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms. Shaheen, R.M., Tseng, W.W., Davis, D.W., Liu, W., Reinmuth, N., Vellagas, R., Wieczorek, A.A., Ogura, Y., McConkey, D.J., Drazan, K.E., Bucana, C.D., McMahon, G., Ellis, L.M. Cancer Res. (2001)
- Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E., Hanahan, D. J. Clin. Invest. (2003)
- In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy. Ma, L., Francia, G., Viloria-Petit, A., Hicklin, D.J., du Manoir, J., Rak, J., Kerbel, R.S. Cancer Res. (2005)
- Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling. Godl, K., Gruss, O.J., Eickhoff, J., Wissing, J., Blencke, S., Weber, M., Degen, H., Brehmer, D., Orfi, L., Horváth, Z., Kéri, G., Müller, S., Cotten, M., Ullrich, A., Daub, H. Cancer Res. (2005)
- Inhibition of peritoneal dissemination of ovarian cancer by tyrosine kinase receptor inhibitor SU6668 (TSU-68). Machida, S., Saga, Y., Takei, Y., Mizuno, I., Takayama, T., Kohno, T., Konno, R., Ohwada, M., Suzuki, M. Int. J. Cancer (2005)
- Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. Klenke, F.M., Abdollahi, A., Bertl, E., Gebhard, M.M., Ewerbeck, V., Huber, P.E., Sckell, A. BMC Cancer (2007)
- SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Abdollahi, A., Lipson, K.E., Han, X., Krempien, R., Trinh, T., Weber, K.J., Hahnfeldt, P., Hlatky, L., Debus, J., Howlett, A.R., Huber, P.E. Cancer Res. (2003)
- Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Shaheen, R.M., Davis, D.W., Liu, W., Zebrowski, B.K., Wilson, M.R., Bucana, C.D., McConkey, D.J., McMahon, G., Ellis, L.M. Cancer Res. (1999)
- Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Griffin, R.J., Williams, B.W., Wild, R., Cherrington, J.M., Park, H., Song, C.W. Cancer Res. (2002)
- Down-modulation of monocyte transendothelial migration and endothelial adhesion molecule expression by fibroblast growth factor: reversal by the anti-angiogenic agent SU6668. Zhang, H., Issekutz, A.C. Am. J. Pathol. (2002)
- The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Garofalo, A., Naumova, E., Manenti, L., Ghilardi, C., Ghisleni, G., Caniatti, M., Colombo, T., Cherrington, J.M., Scanziani, E., Nicoletti, M.I., Giavazzi, R. Clin. Cancer Res. (2003)
- Dose-finding study of the multitargeted tyrosine kinase inhibitor SU6668 in patients with advanced malignancies. Kuenen, B.C., Giaccone, G., Ruijter, R., Kok, A., Schalkwijk, C., Hoekman, K., Pinedo, H.M. Clin. Cancer Res. (2005)
- An Orally Administered Multitarget Tyrosine Kinase Inhibitor, SU11248, Is a Novel Potent Inhibitor of Thyroid Oncogenic RET/Papillary Thyroid Cancer Kinases. Kim, D.W., Jo, Y.S., Jung, H.S., Chung, H.K., Song, J.H., Park, K.C., Park, S.H., Hwang, J.H., Rha, S.Y., Kweon, G.R., Lee, S.J., Jo, K.W., Shong, M. J. Clin. Endocrinol. Metab. (2006)
- A multitargeted receptor tyrosine kinase inhibitor, SU6668, does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. Duan, W.R., Patyna, S., Kuhlmann, M.A., Li, S., Blomme, E.A. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2006)
- Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Whatmore, J.L., Swann, E., Barraja, P., Newsome, J.J., Bunderson, M., Beall, H.D., Tooke, J.E., Moody, C.J. Angiogenesis (2002)
- Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668. Davis, D.W., Takamori, R., Raut, C.P., Xiong, H.Q., Herbst, R.S., Stadler, W.M., Heymach, J.V., Demetri, G.D., Rashid, A., Shen, Y., Wen, S., Abbruzzese, J.L., McConkey, D.J. Clin. Cancer Res. (2005)
- The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Ning, S., Laird, D., Cherrington, J.M., Knox, S.J. Radiat. Res. (2002)