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Chemical Compound Review

CHLORETONE     1,1,1-trichloro-2-methyl- propan-2-ol

Synonyms: Clortran, Sedaform, Chloreton, Chlorbutol, Chlorobutanol, ...
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Disease relevance of Chlorbutol


High impact information on Chlorbutol


Chemical compound and disease context of Chlorbutol


Biological context of Chlorbutol


Anatomical context of Chlorbutol

  • The effects of the preservative chlorobutanol on primary and secondary endings of muscle spindles isolated from the tenuissimus muscle of the cat were investigated in this study [13].
  • Interaction of light and chlorobutanol on Limulus ventral photoreceptor potential latency [15].
  • Chlorobutanol does not alter the sodium permeability of the receptor cell membrane but it may increase the rate of the process or processes occurring during the latent period of the receptor potential [16].
  • The distribution of surface areas of the squamous cells in the treated eyes was shifted to slightly larger values than in the controls after use of the chlorobutanol-containing product but the number of epithelial cell craters/cell was unchanged from that of the controls [17].
  • The results confirm the lack of gross cytotoxic effect of chlorobutanol-preserved artificial tears and indicate that the corneal epithelium can adapt to the use of a polymer-containing artificial tear [18].

Associations of Chlorbutol with other chemical compounds


Gene context of Chlorbutol

  • It is suggested that these concentrations of chlorbutanol and benzalkonium chloride did not affect the stability of the tear film lipid layer as indicated by an altered TER [22].

Analytical, diagnostic and therapeutic context of Chlorbutol


  1. Hypersensitivity to chlorobutanol in DDAVP solution. Itabashi, A., Katayama, S., Yamaji, T. Lancet (1982) [Pubmed]
  2. Bronchoconstrictor additives in bronchodilator solutions. Asmus, M.J., Sherman, J., Hendeles, L. J. Allergy Clin. Immunol. (1999) [Pubmed]
  3. The effect of oxytocin on the contractile force of human atrial trabeculae. Rosaeg, O.P., Cicutti, N.J., Labow, R.S. Anesth. Analg. (1998) [Pubmed]
  4. Chlorobutanol toxicity. Nordt, S.P. The Annals of pharmacotherapy. (1996) [Pubmed]
  5. Anaphylactic shock from chlorobutanol-preserved oxytocin. Hofmann, H., Goerz, G., Plewig, G. Contact Derm. (1986) [Pubmed]
  6. Sharp fall in blood pressure after injection of heparin containing chlorbutol. Bowler, G.M., Galloway, D.W., Meiklejohn, B.H., Macintyre, C.C. Lancet (1986) [Pubmed]
  7. QTc interval prolongation associated with intravenous methadone. Kornick, C.A., Kilborn, M.J., Santiago-Palma, J., Schulman, G., Thaler, H.T., Keefe, D.L., Katchman, A.N., Pezzullo, J.C., Ebert, S.N., Woosley, R.L., Payne, R., Manfredi, P.L. Pain (2003) [Pubmed]
  8. Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. Chen, S.L., Yang, W.C., Huang, T.P., Wann, S.A., Teng, C.M. Thromb. Haemost. (1990) [Pubmed]
  9. Dual effects of chlorobutanol on secretory response and intracellular Ca2+ dynamics in isolated pancreatic acini of the rat. Habara, Y., Kanno, T. Br. J. Pharmacol. (1993) [Pubmed]
  10. The effects of chlorbutol on skeletal muscle sarcoplasmic reticulum function in porcine malignant hyperpyrexia. Sim, A.T., White, M.D., Denborough, M.A. Int. J. Biochem. (1987) [Pubmed]
  11. Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Smith, W.S., Dowd, C.F., Johnston, S.C., Ko, N.U., DeArmond, S.J., Dillon, W.P., Setty, D., Lawton, M.T., Young, W.L., Higashida, R.T., Halbach, V.V. Stroke (2004) [Pubmed]
  12. The airways effects of inhaled chlorbutol in asthmatic subjects. Windom, H., Burgess, C., Crane, J., Beasley, R. Eur. Respir. J. (1990) [Pubmed]
  13. Effects of chlorobutanol on primary and secondary endings of isolated cat muscle spindles. Fischer, M. Brain Res. (2000) [Pubmed]
  14. Effects of anesthetic treatment on motor neuron death in xenopus. Olek, A.J., Edwards, C. Brain Res. (1980) [Pubmed]
  15. Interaction of light and chlorobutanol on Limulus ventral photoreceptor potential latency. Wulff, V.J., Fahy, J.L. Brain Res. Bull. (1980) [Pubmed]
  16. The latent period of the Limulus lateral eye receptor potential: action of chlorobutanol. Wulff, V.J., Jahy, J.L. Brain Res. Bull. (1977) [Pubmed]
  17. Acute effects of chlorobutanol- or benzalkonium chloride-containing artificial tears on the surface features of rabbit corneal epithelial cells. Doughty, M.J. Optometry and vision science : official publication of the American Academy of Optometry. (1994) [Pubmed]
  18. Effect of the use of artificial tears on the size of squamous cells of the rabbit corneal epithelium evaluated by scanning electron microscopy. Doughty, M.J. Optometry and vision science : official publication of the American Academy of Optometry. (1992) [Pubmed]
  19. Oxytocin is luteolytic in the rhesus monkey (Macaca mulatta). Auletta, F.J., Paradis, D.K., Wesley, M., Duby, R.T. J. Reprod. Fertil. (1984) [Pubmed]
  20. Effects of artificial tears on corneal epithelial permeability in dry eyes. Göbbels, M., Spitznas, M. Graefes Arch. Clin. Exp. Ophthalmol. (1991) [Pubmed]
  21. Total bilirubin level in relation to excipients in parenteral morphine sulfate administered to seriously ill newborn infants. Lesko, S.M., Mitchell, A.A. Paediatric and perinatal epidemiology. (1994) [Pubmed]
  22. Effect of preservatives in artificial tear solutions on tear film evaporation. Tomlinson, A., Trees, G.R. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (1991) [Pubmed]
  23. Estimation of chlorbutanol by electron capture gas chromatography. Smith, H., Thorpe, J.W. J. Chromatogr. (1977) [Pubmed]
  24. Analysis of chlorobutanol in ophthalmic ointments and aqueous solutions by reverse-phase high-performance liquid chromatography. Dunn, D.L., Jones, W.J., Dorsey, E.D. Journal of pharmaceutical sciences. (1983) [Pubmed]
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