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Chemical Compound Review

AG-E-83201     tetracos-15-enoic acid

Synonyms: ACMC-209koi, ACMC-20mlkn, ANW-31072, CTK0E9629, CTK0G0636, ...
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Disease relevance of Nervonic acid


High impact information on Nervonic acid


Anatomical context of Nervonic acid


Associations of Nervonic acid with other chemical compounds


Gene context of Nervonic acid

  • NA-binding to pol. beta could be stopped with a non-ionic detergent, but the binding to pol. alpha or HIV-RT could not [17].
  • Increased levels of 26:0 are accompanied by decreased nervonic acid biosynthesis in skin fibroblasts from ALD patients [3].
  • Among the C18 to C24 fatty acids examined, the strongest inhibitor was a C24 fatty acid, nervonic acid (NA), and the weakest was a C18 fatty acid, linoleic acid (LA) [17].

Analytical, diagnostic and therapeutic context of Nervonic acid


  1. Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. Dadras, S.S., Thorgeirsson, S.S., Rao, M.S., Reddy, J.K. Int. J. Oncol. (1998) [Pubmed]
  2. Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase. Kasai, N., Mizushina, Y., Sugawara, F., Sakaguchi, K. J. Biochem. (2002) [Pubmed]
  3. Nervonic acid and demyelinating disease. Sargent, J.R., Coupland, K., Wilson, R. Med. Hypotheses (1994) [Pubmed]
  4. Composition and permeability of syncytiotrophoblast plasma membranes in pregnancies complicated by intrauterine growth restriction. Powell, T.L., Jansson, T., Illsley, N.P., Wennergren, M., Korotkova, M., Strandvik, B. Biochim. Biophys. Acta (1999) [Pubmed]
  5. Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. Sandhir, R., Khan, M., Chahal, A., Singh, I. J. Lipid Res. (1998) [Pubmed]
  6. Incorporation of very-long-chain fatty acids into sphingolipids of cultured neural cells. Saito, M., Saito, M. J. Neurochem. (1991) [Pubmed]
  7. The fatty acid composition of triglycerides in arteries, depot fat and serum of amputated diabetics. Singer, P., Gnauck, G., Honigmann, G., Schliack, V., Laeuter, J. Atherosclerosis (1977) [Pubmed]
  8. Nervonic acid in red blood cell sphingomyelin in premature infants: an index of myelin maturation? Babin, F., Sarda, P., Limasset, B., Descomps, B., Rieu, D., Mendy, F., Crastes de Paulet, A. Lipids (1993) [Pubmed]
  9. Effects of feeding Lunaria oil rich in nervonic and erucic acids on the fatty acid compositions of sphingomyelins from erythrocytes, liver, and brain of the quaking mouse mutant. Cook, C., Barnett, J., Coupland, K., Sargent, J. Lipids (1998) [Pubmed]
  10. Lipid composition in human breast milk from Granada (Spain): changes during lactation. Sala-Vila, A., Castellote, A.I., Rodriguez-Palmero, M., Campoy, C., López-Sabater, M.C. Nutrition (Burbank, Los Angeles County, Calif.) (2005) [Pubmed]
  11. Nervonic acid biosynthesis by erucyl-CoA elongation in normal and quaking mouse brain microsomes. Elongation of other unsaturated fatty acyl-CoAs (mono and poly-unsaturated). Bourre, J.M., Daudu, O., Baumann, N. Biochim. Biophys. Acta (1976) [Pubmed]
  12. Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8kDa domain of DNA polymerase beta. Murakami, S., Kamisuki, S., Takata, K., Kasai, N., Kimura, S., Mizushina, Y., Ohta, K., Sugawara, F., Sakaguchi, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. The effect of borage oil consumption on the composition of individual phospholipids in human platelets. Barre, D.E., Holub, B.J. Lipids (1992) [Pubmed]
  14. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. Chen, J.R., Hsu, S.F., Hsu, C.D., Hwang, L.H., Yang, S.C. J. Nutr. Biochem. (2004) [Pubmed]
  15. The triglyceride fatty acid pattern in arterial wall, adipose tissue and serum of amputated diabetic subjects. Singer, P., Gnauck, G., Honigmann, G., Schliack, V., Läuter, I. Cor et vasa. (1978) [Pubmed]
  16. Detection of tissues of the central nervous system (CNS) as specified risk material (SRM) in meat products by means of gas chromatography-mass spectrometry (GC-MS). Biedermann, W., Lücker, E., Hensel, A. Berl. Munch. Tierarztl. Wochenschr. (2002) [Pubmed]
  17. The inhibitory action of fatty acids on DNA polymerase beta. Mizushina, Y., Yoshida, S., Matsukage, A., Sakaguchi, K. Biochim. Biophys. Acta (1997) [Pubmed]
  18. Influence of structural modifications on the phase behavior of semi-synthetic cerebroside sulfate. Boggs, J.M., Koshy, K.M., Rangaraj, G. Biochim. Biophys. Acta (1988) [Pubmed]
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