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Chemical Compound Review

Barnidipino     [(3S)-1-benzylpyrrolidin-3-yl] methyl 2,6...

Synonyms: barnidipine, Barnidipinum, Mepirodipine, SureCN678277, AC1Q1ZXQ, ...
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Disease relevance of Mepirodipine


High impact information on Mepirodipine


Chemical compound and disease context of Mepirodipine


Biological context of Mepirodipine


Anatomical context of Mepirodipine


Associations of Mepirodipine with other chemical compounds


Gene context of Mepirodipine

  • Although no renal histological changes were observed after 3 weeks of treatment with barnidipine, the level of expression of PDGF B-chain mRNA in glomeruli was significantly reduced relative to that in control SHR [22].
  • We investigated the effect of barnidipine hydrochloride, a Ca(2+) channel blocker, on the glomerular level of mRNA expression of platelet-derived growth factor (PDGF) B-chain and transforming growth factor (TGF)-beta(1) in spontaneously hypertensive rats (SHR) with reverse transcription and polymerase chain reaction [22].
  • Barnidipine significantly reduced the nighttime ambulatory SBP only in group 2 and the nighttime ambulatory DBP in groups 2 and 4 [1].
  • Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker [23].
  • 4. Barnidipine (1 and 3 mg/kg p.o.) increased plasma renin activity dose-dependently [2].

Analytical, diagnostic and therapeutic context of Mepirodipine


  1. Evaluation of the antihypertensive effect of barnidipine, a dihydropyridine calcium entry blocker, as determined by the ambulatory blood pressure level averaged for 24 h, daytime, and nighttime. Barnidipine Study Group. Imai, Y., Abe, K., Nishiyama, A., Sekino, M., Yoshinaga, K. Am. J. Hypertens. (1997) [Pubmed]
  2. Hemodynamic effects of barnidipine hydrochloride in conscious squirrel monkeys. Shibasaki, M., Inagaki, O., Takenaka, T. Gen. Pharmacol. (1994) [Pubmed]
  3. Effect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a pilot study. Spirou, A., Rizos, E., Liberopoulos, E.N., Kolaitis, N., Achimastos, A., Tselepis, A.D., Elisaf, M. J. Cardiovasc. Pharmacol. Ther. (2006) [Pubmed]
  4. A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats. Yamada, S., Matsuoka, Y., Kato, Y., Kimura, R., Inagaki, O. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  5. Preferential renal and mesenteric vasodilation induced by barnidipine and amlodipine in spontaneously hypertensive rats. Janssen, B.J., Kam, K.L., Smits, J.F. Naunyn Schmiedebergs Arch. Pharmacol. (2001) [Pubmed]
  6. Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Katoh, M., Nakajima, M., Yamazaki, H., Yokoi, T. Pharm. Res. (2000) [Pubmed]
  7. Inhibition of a solid phase reaction among excipients that accelerates drug release from a solid dispersion with aging. Mizuno, M., Hirakura, Y., Yamane, I., Miyanishi, H., Yokota, S., Hattori, M., Kajiyama, A. International journal of pharmaceutics. (2005) [Pubmed]
  8. Efficacy and tolerability of once-daily barnidipine in the clinical management of patients with mild to moderate essential hypertension. Spieker, C. Blood pressure. Supplement. (1998) [Pubmed]
  9. Efficacy and safety of barnidipine compared with felodipine in the treatment of hypertension in Chinese patients. Liau, C.S., Chien, K.L., Chao, C.L., Lee, T.M. J. Int. Med. Res. (2002) [Pubmed]
  10. An open-label, randomized, controlled, 4-week comparative clinical trial of barnidipine hydrochloride, a calcium-channel blocker, and benazepril, an angiotensin-converting enzyme inhibitor, in Chinese patients with renal parenchymal hypertension. Chen, X., Zheng, F., Chen, P., Tang, L., Wei, R., Yu, Y., Su, Y., Kikkawa, T., Yamamoto, M. J. Int. Med. Res. (2006) [Pubmed]
  11. Treatment of hypertension in the very old. Otterstad, J.E., Ruilope, L.M. International journal of clinical practice. Supplement. (2000) [Pubmed]
  12. Comparative effects of a new calcium channel antagonist, mepirodipine, on rabbit spontaneously beating sino-atrial node cells. Satoh, H., Hashimoto, K. Eur. J. Pharmacol. (1991) [Pubmed]
  13. Low-dose calcium antagonists reduce energy demand and cellular damage of isolated hearts during both ischemia and reperfusion. Becker, B.F., Möbert, J. Naunyn Schmiedebergs Arch. Pharmacol. (1999) [Pubmed]
  14. Barnidipine, a novel calcium antagonist for once-daily treatment of hypertension: a multicenter, double-blind, placebo-controlled, dose-ranging study. Dutch Barnidipine Multicenter Study Group. Hart, W., Holwerda, N.J. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1997) [Pubmed]
  15. Voltage-dependent effects of barnidipine in rat vascular smooth muscle. Wegener, J.W., Korstanje, C., Nawrath, H. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  16. Reconsideration of vascular selectivity of dihydropyridine calcium antagonists: comparison of cardiovascular profile of mepirodipine, a novel dihydropyridine consisting of a single stereoisomer with (+)-(S)-(S) conformation, with those of nifedipine and nicardipine. Motomura, S., Hashimoto, K. Jpn. J. Pharmacol. (1990) [Pubmed]
  17. Effect of barnidipine on blood flow to major organs and renal function in anaesthetized dogs and spontaneously hypertensive rats. Saitoh, M., Kasai, C., Ishikawa, J., Masaki, K., Asano, M. Clinical and experimental pharmacology & physiology. Supplement. (1995) [Pubmed]
  18. Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochloride. Nakayama, K., Kashiwabara, T., Yamada, S., Tanaka, Y. Arzneimittel-Forschung. (1989) [Pubmed]
  19. Metabolism and pharmacokinetics of barnidipine hydrochloride, a calcium channel blocker, in man following oral administration of its sustained release formulation. Teramura, T., Watanabe, T., Higuchi, S., Hashimoto, K. Xenobiotica (1997) [Pubmed]
  20. Natriuretic effect of barnidipine, a long-acting dihydropyridine calcium channel blocker, in patients with essential hypertension. Ohya, Y., Abe, I., Ohta, Y., Onaka, U., Fujii, K., Kagiyama, S., Fujishima-Nakao, Y., Fujishima, M. International journal of clinical pharmacology and therapeutics. (2000) [Pubmed]
  21. Comparative study of barnidipine and felodipine in Chinese patients with essential hypertension. Zhu, W., Li, T., Ni, C., Liu, H., Fang, L., Shang, M., Kikkawa, T., Katoh, H., Yamamoto, M. J. Int. Med. Res. (2006) [Pubmed]
  22. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Hashimoto, M., Yamauchi, T., Ogura, T., Oishi, T., Mimura, Y., Otsuka, F., Kashihara, N., Makino, H. American journal of nephrology. (1999) [Pubmed]
  23. Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Teramura, T., Fukunaga, Y., Van Hoogdalem, E.J., Watanabe, T., Higuchi, S. Xenobiotica (1997) [Pubmed]
  24. Determination of a novel calcium channel antagonist, mepirodipine, in plasma by radioreceptor assay using (+)-[3H]PN 200-110. Yamada, S., Matsuoka, Y., Suzuki, N., Sugimoto, N., Kato, Y., Kimura, R. Pharm. Res. (1992) [Pubmed]
  25. Determination of barnidipine in human serum and dog plasma by HPLC with electrochemical detection. Takamura, K., Abdel-Wadood, H.M., Kusu, F., Rafaat, I.H., Saleh, G.A., el-Rabbat, N.A., Otagiri, M. Biol. Pharm. Bull. (1995) [Pubmed]
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