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Chemical Compound Review

Modamide     3,5-diamino-6-chloro-N...

Synonyms: Nirulid, AMIPRAMIDINE, Prestwick_15, Midamor (TN), CHEBI:2640, ...
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Disease relevance of AMILORIDE


High impact information on AMILORIDE

  • In addition, 5-(N,N-hexamethylene) amiloride hydrochloride, an amiloride analogue with specific sodium channel antiport inhibition, resulted in a similar dose-dependent suppression of lipopolysaccharide-stimulated, AM-derived IL-8 production [6].
  • After 4 weeks the dose of felodipine was increased to 10mg twice daily, and Moduretic mite was replaced by Moduretic in patients with a diastolic blood pressure of greater than 80mm Hg [2].
  • Felodipine versus Moduretic. A double-blind parallel-group multicentre study [2].
  • We therefore measured lymphocyte free Mg2+ concentrations in patients with congestive cardiac failure treated with loop diuretics or a frusemide/amiloride mixture (Frumil) and compared them with control subjects [7].
  • Patients treated with loop diuretics did not show lymphocyte intracellular free Mg2+ depletion compared with normal controls, and those on Frumil showed higher intracellular free Mg2+ levels than normal [7].

Chemical compound and disease context of AMILORIDE


Biological context of AMILORIDE


Anatomical context of AMILORIDE


Associations of AMILORIDE with other chemical compounds


Gene context of AMILORIDE

  • A method is applied for the quantitative analysis of Moduretic tablets (Merck Sharp & Dokme International) [21].
  • There is evidence that amiloride (CAS 17440-83-4) has a stimulatory effect on the renin secretion but it is still in question whether this is volume and/or sodium independent [22].
  • This is against unfavourable increments in the mean values of TC, VLDLC, LDLC/HDLC and decrease in HDLC/TC during moduretic treatment phase [23].
  • The effect of a single daily dose of timolol, hydrochlorothiazide and amiloride hydrochloride in fixed combination (Moducren; MDS) in patients with mild to moderate essential hypertension was tested during 1978 in an open study covering 10 weeks per patient [24].

Analytical, diagnostic and therapeutic context of AMILORIDE


  1. Response of thiazide-induced hypokalemia to amiloride. Maronde, R.F., Milgrom, M., Vlachakis, N.D., Chan, L. JAMA (1983) [Pubmed]
  2. Felodipine versus Moduretic. A double-blind parallel-group multicentre study. Krönig, B., Flygt, G. Drugs (1987) [Pubmed]
  3. Moduretic-induced metabolic acidosis and hyperkalaemia. Wan, H.H., Lye, M.D. Postgraduate medical journal. (1980) [Pubmed]
  4. Severe acute interstitial pulmonary edema from Moduretic (amiloride plus hydrochlorothiazide). Kounis, N.G., Nikolaou, S., Zavras, G., Siablis, D. Annals of allergy. (1986) [Pubmed]
  5. Nano-liposomal dry powder inhaler of Amiloride Hydrochloride. Chougule, M.B., Padhi, B.K., Misra, A. Journal of nanoscience and nanotechnology. (2006) [Pubmed]
  6. Suppression of human alveolar macrophage-derived cytokines by amiloride. Rolfe, M.W., Kunkel, S.L., Rowens, B., Standiford, T.J., Cragoe, E.J., Strieter, R.M. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  7. Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride. Ng, L.L., Garrido, M.C., Davies, J.E., Brochwicz-Lewinski, M.J., Tan, L.B. British journal of clinical pharmacology. (1992) [Pubmed]
  8. Differential antihypertensive effect of acebutolol and hydrochlorothiazide/amiloride hydrochloride combination on elevated exercise blood pressures in hypertensive patients. Franz, I.W. Am. J. Cardiol. (1980) [Pubmed]
  9. A comparative study of Moducren and Moduretic and their effect on plasma potassium in essential hypertension. Jaffé, G., Grimshaw, J.J., Vallé-Jones, J.C., Warnock, J.M. The Practitioner. (1982) [Pubmed]
  10. Comparative study of the efficacy and tolerance of capozide and moduretic administered in a single daily dose for the treatment of chronic moderate arterial hypertension. Clementy, J., Schwebig, A., Mazaud, C., Justal, A., Bricaud, H. Postgraduate medical journal. (1986) [Pubmed]
  11. Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year's treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double-blind, randomized study. Otterstad, J.E., Froeland, G., Wasenius Soeyland, A.K., Knutsen, K.M., Ekeli, T. J. Intern. Med. (1992) [Pubmed]
  12. Mechanism of action, pharmacokinetics, adverse effects, and therapeutic uses of amiloride hydrochloride, a new potassium-sparing diuretic. Vidt, D.G. Pharmacotherapy (1981) [Pubmed]
  13. Frusemide/amiloride combination ('Frumil') in heart failure: an open, multi-centre study in general practice. Townsend, H.A., Waddy, A.L., Eason, C.T., Richards, H.H. Current medical research and opinion. (1984) [Pubmed]
  14. Effects of diuretics on renal kallikrein gene expression in rats. Penschow, J.D., Bulmer, B. Clinical and experimental pharmacology & physiology. Supplement. (1998) [Pubmed]
  15. Effect of moduretic and aldactone on electrolytes in skeletal muscle in patients on long-term diuretic therapy. Widman, L., Dyckner, T., Wester, P.O. Acta Med. Scand. Suppl. (1982) [Pubmed]
  16. Are there differences in the blood-pressure-lowering effect of atenolol vs. hydrochlorothiazide + amiloride (Moduretic) when assessed by standard clinic recordings vs. 24-h ambulatory monitoring? Otterstad, J.E., Froeland, G., Michelsen, S., Ekeli, T. J. Intern. Med. (1992) [Pubmed]
  17. Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells. Scott-Burden, T., Resink, T.J., Baur, U., Bürgin, M., Bühler, F.R. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  18. Simultaneous determination of amiloride hydrochloride and hydrochlorothiazide in synthetic samples and pharmaceutical formulations by multivariate analysis of spectrophotometric data. Ferraro, M.C., Castellano, P.M., Kaufman, T.S. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  19. A simplified approach to the treatment of hypertension. Gillies, A., Morgan, T., Morgan, G., Wilson, M. Med. J. Aust. (1977) [Pubmed]
  20. Lipid profile in 100 men with moderate hypertension treated for 1 year with atenolol or hydrochlorothiazide plus amiloride: a double-blind, randomized study. Otterstad, J.E., Froeland, G., Soeyland, A.K., Illingworth, J.M. Scand. J. Clin. Lab. Invest. (1992) [Pubmed]
  21. Statistical optimization of a reversed-phase liquid chromatographic method for the analysis of amiloride and hydrochlorothiazide in tablets. Zecevic, M., Zivanovic, L.J., Agatonovic-Kustrin, S., Ivanovic, D., Maksimovic, M. Journal of pharmaceutical and biomedical analysis. (2000) [Pubmed]
  22. Volume independent stimulation of renin secretion by a single dose of amiloride in man. Endemann, D., Marienhagen, J., Stubanus, M., Luger, R.J., Fischereder, M., Riegger, G.A., Krämer, B.K. Arzneimittel-Forschung. (2002) [Pubmed]
  23. Changes in lipid and lipoprotein values during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients. Ahaneku, J.E., Taylor, G.O., Agbedana, E.O., Walker, O., Salako, L.A. JPMA. The Journal of the Pakistan Medical Association. (1994) [Pubmed]
  24. Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial. Pittaway, D. S. Afr. Med. J. (1980) [Pubmed]
  25. A spectrophotometric-partial least squares (PLS-1) method for the simultaneous determination of furosemide and amiloride hydrochloride in pharmaceutical formulations. Ferraro, M.C., Castellano, P.M., Kaufman, T.S. Journal of pharmaceutical and biomedical analysis. (2001) [Pubmed]
  26. New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme). Macfie, H.L., Colvin, C.L., Anderson, P.O. Drug intelligence & clinical pharmacy. (1981) [Pubmed]
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