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Gene Review

Olr1  -  oxidized low density lipoprotein (lectin...

Mus musculus

Synonyms: LOX-1, Lectin-like oxLDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lox1, ...
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Disease relevance of Olr1


High impact information on Olr1


Chemical compound and disease context of Olr1


Biological context of Olr1

  • To further explore the relationship between the structure and function of LOX-1, a mutagenesis study was carried out [7].
  • The results indicate that alloimmune responses induce up-regulation of LOX-1 mRNA in transplanted hearts [8].
  • Lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) is a cell-surface endocytosis receptor for atherogenic oxLDL, which is highly expressed in endothelial cells [9].
  • There was evidence of intense oxidative stress (nitrotyrosine staining), inflammation (CD68 staining), and expression of adhesion molecules and the ox-LDL receptor LOX-1 (gene array analysis) in the atherosclerotic tissues [10].
  • CONCLUSIONS: Our findings suggest that histone acetylation could play some role in atherogenesis by modulating expressions of oxLDL receptor and some proatherogenic genes [11].

Anatomical context of Olr1

  • BACKGROUND: We hypothesized that atherosclerosis inhibits NO-mediated endothelium-dependent dilation of coronary arterioles through interaction of ox-LDL with its receptor, LOX-1, through the production of O2ÿ- in endothelial cells [12].
  • CONCLUSION: LOX-1 induction in arthritic joints might play a role in promoting joint inflammation and cartilage destruction by mediating leukocyte infiltration into the arthritic joints of ZIA rats [6].
  • These data imply that lipoproteins can further contribute to foam cell development in atherosclerosis by up-regulating a major OxLDL receptor [13].
  • Ox-LDL, a ligand of LOX-1, was also detected in articular chondrocytes [6].
  • LOX-1 was also expressed weakly on both joint cartilage and synovium [6].

Associations of Olr1 with chemical compounds

  • CONCLUSIONS: These results suggest that ox-LDL impairs endothelium-dependent NO-mediated dilation of coronary arterioles by activation of a signaling cascade involving LOX-1 and NAD(P)H oxidase expression [12].
  • This was strong evidence for the involvement of all six Cys in the intrachain disulfide bonds required for proper folding, processing and transport of LOX-1 [7].
  • Administration of anti-LOX-1 antibody, which blocks LOX-1 activity, suppressed joint swelling (by 33.5%), leukocyte infiltration, and joint nitrite accumulation at 24 hours, as well as cartilage destruction at 7 days, compared with control rats [6].
  • While rosuvastatin and candesartan each had a small inhibitory effect on the expression of LOX-1 in the atherosclerotic tissues, the combination totally blocked the up-regulation of LOX-1 [2].
  • By means of glycyrrhizin (GL)-affinity column chromatography, a GL-binding lipoxygenase (gbLOX) was selectively purified from the partially purified soybean LOX-1 fraction [14].

Analytical, diagnostic and therapeutic context of Olr1

  • We cloned mouse LOX-1 cDNA to take advantage of a gene-targeting technique to clarify the role of LOX-1 in vivo [15].
  • LOX-1 mRNA expression was measured by RT-PCR [8].
  • Marked increase in LOX-1 mRNA expression was observed only in allografts [8].
  • METHODS: LOX-1 expression and ox-LDL accumulation in arthritic joints were detected by immunohistochemistry using specific mouse anti-LOX-1 and anti-ox-LDL monoclonal antibodies, respectively [6].
  • Increased expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the receptor for OxLDL in endothelial cells, has been demonstrated in the atherosclerotic plaques from experimental atherosclerotic animal models and human clinical samples [16].


  1. Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction. Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Romeo, F., Mehta, J.L. J. Am. Coll. Cardiol. (2003) [Pubmed]
  2. Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan. Chen, J., Li, D., Schaefer, R., Mehta, J.L. Atherosclerosis (2006) [Pubmed]
  3. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine. Sambrano, G.R., Steinberg, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns. Esen, N., Kielian, T. J. Immunol. (2006) [Pubmed]
  5. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Coraci, I.S., Husemann, J., Berman, J.W., Hulette, C., Dufour, J.H., Campanella, G.K., Luster, A.D., Silverstein, S.C., El-Khoury, J.B. Am. J. Pathol. (2002) [Pubmed]
  6. Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T., Sawamura, T. Arthritis Rheum. (2002) [Pubmed]
  7. Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor. Shi, X., Niimi, S., Ohtani, T., Machida, S. J. Cell. Sci. (2001) [Pubmed]
  8. Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts. Suga, M., Sawamura, T., Nakatani, T., Kitamura, S. Transplant. Proc. (2004) [Pubmed]
  9. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Chen, M., Narumiya, S., Masaki, T., Sawamura, T. Biochem. J. (2001) [Pubmed]
  10. Suppression of atherogenesis by delivery of TGFbeta1ACT using adeno-associated virus type 2 in LDLR knockout mice. Li, D., Liu, Y., Chen, J., Velchala, N., Amani, F., Nemarkommula, A., Chen, K., Rayaz, H., Zhang, D., Liu, H., Sinha, A.K., Romeo, F., Hermonat, P.L., Mehta, J.L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. Choi, J.H., Nam, K.H., Kim, J., Baek, M.W., Park, J.E., Park, H.Y., Kwon, H.J., Kwon, O.S., Kim, D.Y., Oh, G.T. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  12. Anti-LOX-1 rescues endothelial function in coronary arterioles in atherosclerotic ApoE knockout mice. Xu, X., Gao, X., Potter, B.J., Cao, J.M., Zhang, C. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  13. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. Han, J., Hajjar, D.P., Febbraio, M., Nicholson, A.C. J. Biol. Chem. (1997) [Pubmed]
  14. Physiological correlation between glycyrrhizin, glycyrrhizin-binding lipoxygenase and casein kinase II. Shimoyama, Y., Ohtaka, H., Nagata, N., Munakata, H., Hayashi, N., Ohtsuki, K. FEBS Lett. (1996) [Pubmed]
  15. High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1). Hoshikawa, H., Sawamura, T., Kakutani, M., Aoyama, T., Nakamura, T., Masaki, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  16. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Inoue, K., Arai, Y., Kurihara, H., Kita, T., Sawamura, T. Circ. Res. (2005) [Pubmed]
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