The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Olr1  -  oxidized low density lipoprotein (lectin...

Rattus norvegicus

Synonyms: LOX-1, Lectin-like oxLDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Lox1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Oldlr1

  • Preadministration of anti-LOX-1 antibody reduced the degree of leukopenia and completely rescued the animals, whereas control IgG did not [1].
  • In a model of low-dose endotoxin-induced uveitis, anti-LOX-1 antibody efficiently suppressed leukocyte infiltration and protein exudation [1].
  • Here, we report on the role of LOX-1 in intimal hyperplasia, in which proinflammatory and oxidative stimuli are increased [2].
  • Quite unexpectedly, the expression was dramatically up-regulated in the aorta in hypertensive SHR-SP/Izm rats compared with very low levels in control WKY/Izm rats, suggesting a potential role for LOX-1 in the pathogenesis of hypertension as well as atherosclerosis [3].
  • LOX-1 antibody, but not nonspecific IgG, also reduced myocardial infarct size (P < 0.01 vs. saline-treated I/R group) [4].

High impact information on Oldlr1


Chemical compound and disease context of Oldlr1

  • In Ang II-infused rats SBP, aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels were significantly reduced by amlodipine treatment [5].
  • After 1 h ischemia of bilateral kidneys plus 3, 6, or 12 h reperfusion, we first revealed that LOX-1 mRNA expression was increased in renal cortex and medulla at 6 h after reperfusion, which was decreased by L-arginine supplement [6].

Biological context of Oldlr1


Anatomical context of Oldlr1


Associations of Oldlr1 with chemical compounds

  • Doxorubicin-induced LOX-1 expression in a concentration- and time-dependent fashion [7].
  • In this study, we examined the vascular expression of LOX-1 in streptozotocin-induced diabetic rats [10].
  • In cultured aortic endothelial cells, diabetic rat serum and advanced glycation endproducts-BSA induced LOX-1 expression, while control rat serum along with high glucose did not [10].
  • The present study provides evidence that HHcy does produce renal oxidative stress mediated by lipid peroxidation, and that the increased kidney MDA displayed by FF animals may enhance kidney antioxidant activity and thereby attenuate both kidney damage and expression of LOX-1 [11].
  • However, the molecular mechanisms by which betaxolol, a specific beta 1-antagonist, stimulates endothelial NO synthase (eNOS) expression associated with LOX-1 and VEGF are unclear [12].

Enzymatic interactions of Oldlr1

  • We also demonstrated that amlodipine or manidipine prevented the Ang II-induced increase in lectin-like oxidized low-density lipoprotein receptor1 (LOX-1) content, thereby restoring control levels [13].

Regulatory relationships of Oldlr1

  • The activity of p38 MAPK was increased during I/R (P < 0.01 vs. sham control), and use of LOX-1 antibody inhibited p38 MAPK activation (P < 0.01) [4].
  • METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1 [14].
  • Antioxidant catalase also blocked LOX-1-induced apoptosis as well as activation of p38 MAPK [14].

Other interactions of Oldlr1


Analytical, diagnostic and therapeutic context of Oldlr1


  1. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T., Sawamura, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M., Sawamura, T. Cardiovasc. Res. (2006) [Pubmed]
  3. Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1). Nagase, M., Hirose, S., Fujita, T. Biochem. J. (1998) [Pubmed]
  4. LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T., Mehta, J.L. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  5. Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats. Zhou, M.S., Jaimes, E.A., Raij, L. Am. J. Hypertens. (2004) [Pubmed]
  6. Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and the opposing effect of L-arginine. Kosaka, H., Yoneyama, H., Zhang, L., Fujii, S., Yamamoto, A., Igarashi, J. FASEB J. (2003) [Pubmed]
  7. Doxorubicin-induced expression of LOX-1 in H9c2 cardiac muscle cells and its role in apoptosis. Spallarossa, P., Fabbi, P., Manca, V., Garibaldi, S., Ghigliotti, G., Barisione, C., Altieri, P., Patrone, F., Brunelli, C., Barsotti, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Nakagawa, T., Yasuda, T., Hoshikawa, H., Shimizu, M., Kakinuma, T., Chen, M., Masaki, T., Nakamura, T., Sawamura, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Ueno, T., Kaname, S., Takaichi, K., Nagase, M., Tojo, A., Onozato, M.L., Fujita, T. Hypertens. Res. (2003) [Pubmed]
  10. Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T., Sawamura, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  11. Hyperhomocysteinaemia induced by dietary folate restriction causes kidney oxidative stress in rats. Díez, N., Pérez, R., Hurtado, V., Santidrián, S. Br. J. Nutr. (2005) [Pubmed]
  12. Betaxolol stimulates eNOS production associated with LOX-1 and VEGF in Dahl salt-sensitive rats. Kobayashi, N., Yoshida, K., Mita, S., Honda, T., Hara, K., Nakano, S., Tsubokou, Y., Matsuoka, H. J. Hypertens. (2004) [Pubmed]
  13. Calcium [corrected] channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells. Toba, H., Shimizu, T., Miki, S., Inoue, R., Yoshimura, A., Tsukamoto, R., Sawai, N., Kobara, M., Nakata, T. Hypertens. Res. (2006) [Pubmed]
  14. Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes. Iwai-Kanai, E., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Toyokuni, S., Adachi, S., Kihara, Y., Sasayama, S. Circulation (2001) [Pubmed]
  15. Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats. Mita, S., Kobayashi, N., Yoshida, K., Nakano, S., Matsuoka, H. J. Hypertens. (2005) [Pubmed]
WikiGenes - Universities