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Gene Review

Arsb  -  arylsulfatase B

Mus musculus

Synonyms: 1110007C02Rik, AI480648, ASB, Arylsulfatase B, As-1, ...
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Disease relevance of Arsb


High impact information on Arsb

  • Homozygous mutant animals exhibit ASB enzyme deficiency and elevated urinary secretion of dermatan sulfate [1].
  • Cells derived from dorsal, intermediate, and ventral regions of the spinal cord all behaved similarly and gave rise to motor neuron-like cells when plated onto Ast-1 [5].
  • Together, these results indicate that precursors in the murine spinal cord can be induced to differentiate into the motor neuron phenotype by factors produced by Ast-1 cells, suggesting that a similar factor(s) produced by cells akin to Ast-1 may regulate motor neuron differentiation in vivo [5].
  • By using cells that expressed the lacZ reporter gene, it was shown that > 93% of cells present on the Ast-1 monolayers were motor neuron-like [5].
  • Time-lapse analysis revealed that the precursors on the Ast-1 monolayers gave rise to neurons either directly or following a single cell division [5].

Chemical compound and disease context of Arsb


Biological context of Arsb


Anatomical context of Arsb

  • As ocular and cardiac impairment are also clinically important manifestations of the MPS VI syndrome, the present study was initiated for detailed biochemical, histologic and functional analysis of cornea, optic nerve and heart in ASB-deficient mice [12].
  • Biochemical evidence for GAG-storage could be obtained for liver, kidney, spleen and myocardium as well as for heart valves, cornea and optic nerve from ASB-deficient mice [12].
  • Neuronal production was optimal under the conditions in which precursors were initially stimulated with basic fibroblast growth factor and then exposed to medium conditioned by an astrocytic cell line, Ast-1, in serum-free medium [13].
  • In addition, the Ast-1 conditioned medium was shown to promote the survival of the neuroepithelial cells [14].
  • Ast-1 cell monolayers were also found to provide a suitable substrate for the prolonged survival (at least 3 days in vitro) of neurofilament positive neurons obtained from E17 mice, whereas neurons plated onto NIH 3T3 cells were all dead after 2 days [14].

Associations of Arsb with chemical compounds


Other interactions of Arsb

  • As-1 and Lth-1 were found to be closely linked using recombinant inbred (RI) strains [8].
  • This isozyme is antigenically similar to cationic arylsulfatase B, displays a similar developmental profile, and can be converted to a form resembling the cationic species by prior treatment with neuraminidase [17].

Analytical, diagnostic and therapeutic context of Arsb


  1. Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI. Evers, M., Saftig, P., Schmidt, P., Hafner, A., McLoghlin, D.B., Schmahl, W., Hess, B., von Figura, K., Peters, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Activity of some hepatic enzymes in schistosomiasis and concomitant alteration of arylsulfatase B. Balbaa, M., El-Kersh, M., Mansour, H., Yacout, G., Ismail, M., Malky, A., Bassiouny, K., Abdel-Monem, N., Kandeel, K. J. Biochem. Mol. Biol. (2004) [Pubmed]
  3. Biochemical characterization of arylsulfatases detected in granulomatous inflammation. Higuchi, M., Ito, Y., Fukuyama, K., Epstein, W.L. Exp. Mol. Pathol. (1984) [Pubmed]
  4. Phosphorylation on protein and carbohydrate moieties of a lysosomal arylsulfatase B variant in human lung cancer transplanted into athymic mice. Gasa, S., Makita, A. J. Biol. Chem. (1983) [Pubmed]
  5. Lineage specification of neuronal precursors in the mouse spinal cord. Richards, L.J., Murphy, M., Dutton, R., Kilpatrick, T.J., Puche, A.C., Key, B., Tan, S.S., Talman, P.S., Bartlett, P.F. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Complete remissions in chemotherapy of lung cancer models induced in mice by asbestos. Smith, W.E., Hubert, D.D., Yazdi, E., Holiat, S.M., Bissell, E.C., Watts, L.M., Baylouny, R.A., Sobel, H.J. Mt. Sinai J. Med. (2005) [Pubmed]
  7. Inhibition of transplanted carcinomas in mice by retinoids but not by vitamin C. Hubert, D.D., Holiat, S.M., Smith, W.E., Baylouny, R.A. Cancer treatment reports. (1983) [Pubmed]
  8. Linkage of loci affecting a murine liver protein and arylsulfatase B to chromosome 13. Elliott, R.W., Daniel, W.L., Taylor, B.A., Novak, E.K. J. Hered. (1985) [Pubmed]
  9. Comparative studies of rodent anionic arylsulfatases. Thompson, D.B., Daniel, W.L., Glaser, J.H. Comp. Biochem. Physiol., B (1985) [Pubmed]
  10. Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2. Manenti, G., Falvella, F.S., Gariboldi, M., Dragani, T.A., Pierotti, M.A. Genomics (1995) [Pubmed]
  11. Assignment of a gene for arylsulfatase B to human chromosome 5 using human-mouse somatic cell hybrids. Hellkuhl, B., Grzeschik, K.H. Cytogenet. Cell Genet. (1978) [Pubmed]
  12. Cardiac and ocular pathologies in a mouse model of mucopolysaccharidosis type VI. Strauch, O.F., Stypmann, J., Reinheckel, T., Martinez, E., Haverkamp, W., Peters, C. Pediatr. Res. (2003) [Pubmed]
  13. De novo generation of neuronal cells from the adult mouse brain. Richards, L.J., Kilpatrick, T.J., Bartlett, P.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  14. The differentiation and survival of murine neurons in vitro is promoted by soluble factors produced by an astrocytic cell line. Kilpatrick, T.J., Talman, P.S., Bartlett, P.F. J. Neurosci. Res. (1993) [Pubmed]
  15. Mammalian arylsulfatases A and B: relative rates of hydrolysis of artificial substrates. Thompson, D.B., Daniel, W.L. Experientia (1986) [Pubmed]
  16. Arylsulfatase B synthesis and clearance in inbred mouse strains. Daniel, W.L. Experientia (1987) [Pubmed]
  17. Comparative studies of murine anionic and cationic arylsulfatase B (1). Harrison, B.W., Daniel, W.L., Abbas, K.J. Experientia (1982) [Pubmed]
  18. Murine liver arylsulfatase B processing influenced by region on chromosome 17. Daniel, W.L., Womack, J.E., Henthorn, P.S. Biochem. Genet. (1981) [Pubmed]
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