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Gene Review

CASP2  -  caspase 2, apoptosis-related cysteine...

Homo sapiens

Synonyms: CASP-2, Caspase-2, ICH1, MGC2181, NEDD-2, ...
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Disease relevance of CASP2


Psychiatry related information on CASP2


High impact information on CASP2


Biological context of CASP2


Anatomical context of CASP2


Associations of CASP2 with chemical compounds


Other interactions of CASP2

  • No change is apparent between CASP2 and CASP3 (1998) [18].
  • There was a clear improvement in alignment quality between CASP1 (1994) and CASP2 (1996) [18].
  • Taken together, our results identify the human CASP-2 gene as a member of the SREBP-responsive gene battery that senses lipid levels in cells and raise the possibility that caspase-2 participates in the control of cholesterol and triacylglycerol levels [9].
  • We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region [19].
  • From observed changes in protein phosphatase 2A, CDC25 A, and caspase-2 precursor, a model for the promotion of cell cycle progression by ET-1 stimulation is proposed [20].

Analytical, diagnostic and therapeutic context of CASP2


  1. Cysteine protease CPP32, but not Ich1-L, is expressed in germinal center B cells and their neoplastic counterparts. Xerri, L., Devilard, E., Ayello, C., Brousset, P., Reed, J.C., Emile, J.F., Hassoun, J., Parmentier, S., Birg, F. Hum. Pathol. (1997) [Pubmed]
  2. T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer. Findeisen, P., Kloor, M., Merx, S., Sutter, C., Woerner, S.M., Dostmann, N., Benner, A., Dondog, B., Pawlita, M., Dippold, W., Wagner, R., Gebert, J., von Knebel Doeberitz, M. Cancer Res. (2005) [Pubmed]
  3. Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA). Wakisaka, S., Suzuki, N., Takeba, Y., Shimoyama, Y., Nagafuchi, H., Takeno, M., Saito, N., Yokoe, T., Kaneko, A., Asai, T., Sakane, T. Clin. Exp. Immunol. (1998) [Pubmed]
  4. The clinical significance of caspase regulation in acute leukemia. Faderl, S., Estrov, Z. Leuk. Lymphoma (2001) [Pubmed]
  5. Up-regulation of ICH-1L protein by thromboxane A2 antagonists enhances cisplatin-induced apoptosis in non-small-cell lung-cancer cell lines. Fujimura, M., Kasahara, K., Shirasaki, H., Heki, U., Iwasa, K., Ueda, A., Matsuda, T. J. Cancer Res. Clin. Oncol. (1999) [Pubmed]
  6. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura, Y., Shimohama, S., Kamoshima, W., Ota, T., Matsuoka, Y., Nomura, Y., Smith, M.A., Perry, G., Whitehouse, P.J., Taniguchi, T. Brain Res. (1998) [Pubmed]
  7. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Chou, J.J., Matsuo, H., Duan, H., Wagner, G. Cell (1998) [Pubmed]
  8. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Xue, D., Shaham, S., Horvitz, H.R. Genes Dev. (1996) [Pubmed]
  9. Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2. Logette, E., Le Jossic-Corcos, C., Masson, D., Solier, S., Sequeira-Legrand, A., Dugail, I., Lemaire-Ewing, S., Desoche, L., Solary, E., Corcos, L. Mol. Cell. Biol. (2005) [Pubmed]
  10. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Droin, N., Dubrez, L., Eymin, B., Renvoizé, C., Bréard, J., Dimanche-Boitrel, M.T., Solary, E. Oncogene (1998) [Pubmed]
  11. Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms. Kumar, S., White, D.L., Takai, S., Turczynowicz, S., Juttner, C.A., Hughes, T.P. Hum. Genet. (1995) [Pubmed]
  12. Fold assignments for amino acid sequences of the CASP2 experiment. Rice, D.W., Fischer, D., Weiss, R., Eisenberg, D. Proteins (1997) [Pubmed]
  13. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. Robertson, J.D., Enoksson, M., Suomela, M., Zhivotovsky, B., Orrenius, S. J. Biol. Chem. (2002) [Pubmed]
  14. Activation of caspases in p53-induced transactivation-independent apoptosis. Gao, C., Tsuchida, N. Jpn. J. Cancer Res. (1999) [Pubmed]
  15. Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons. Ekegren, T., Grundström, E., Lindholm, D., Aquilonius, S.M. Acta neurologica Scandinavica. (1999) [Pubmed]
  16. Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis. Amoroso, S., D'Alessio, A., Sirabella, R., Di Renzo, G., Annunziato, L. J. Neurosci. Res. (2002) [Pubmed]
  17. Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells. Osborne, N.N., Nash, M.S., Wood, J.P. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  18. Comparison of performance in successive CASP experiments. Venclovas, C., Zemla, A., Fidelis, K., Moult, J. Proteins (2001) [Pubmed]
  19. Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene. Logette, E., Solary, E., Corcos, L. Biochim. Biophys. Acta (2005) [Pubmed]
  20. Rapid changes in the phosphoproteome show diverse cellular responses following stimulation of human lung fibroblasts with endothelin-1. Stannard, C., Soskic, V., Godovac-Zimmermann, J. Biochemistry (2003) [Pubmed]
  21. Involvement of ICE (Caspase) family in gamma-radiation-induced apoptosis of normal B lymphocytes. Hallan, E., Blomhoff, H.K., Smeland, E.B., Lømo, J. Scand. J. Immunol. (1997) [Pubmed]
  22. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. Que, F.G., Gores, G.J., LaRusso, N.F. Am. J. Physiol. (1997) [Pubmed]
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